Editorial: The piriform cortex in epilepsy

2020 ◽  
Vol 329 ◽  
pp. 113313
Author(s):  
Mohamad Z. Koubeissi
Keyword(s):  
Piriform Cortex

scholarly journals Effects of Lacosamide Treatment on Epileptogenesis, Neuronal Damage and Behavioral Comorbidities in a Rat Model of Temporal Lobe Epilepsy

2021 ◽  
Vol 22 (9) ◽  
pp. 4667
Author(s):  
Michaela Shishmanova-Doseva ◽  
Dimitrinka Atanasova ◽  
Yordanka Uzunova ◽  
Lyubka Yoanidu ◽  
Lyudmil Peychev ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Basolateral Amygdala ◽  
Neuronal Damage ◽  
Piriform Cortex ◽  
Preference Test ◽  
Neuroprotective Activity ◽  
Object Recognition Test ◽  
Beneficial Effects

Clinically, temporal lobe epilepsy (TLE) is the most prevalent type of partial epilepsy and often accompanied by various comorbidities. The present study aimed to evaluate the effects of chronic treatment with the antiepileptic drug (AED) lacosamide (LCM) on spontaneous motor seizures (SMS), behavioral comorbidities, oxidative stress, neuroinflammation, and neuronal damage in a model of TLE. Vehicle/LCM treatment (30 mg/kg, p.o.) was administered 3 h after the pilocarpine-induced status epilepticus (SE) and continued for up to 12 weeks in Wistar rats. Our study showed that LCM attenuated the number of SMS and corrected comorbid to epilepsy impaired motor activity, anxiety, memory, and alleviated depressive-like responses measured in the elevated plus maze, object recognition test, radial arm maze test, and sucrose preference test, respectively. This AED suppressed oxidative stress through increased superoxide dismutase activity and glutathione levels, and alleviated catalase activity and lipid peroxidation in the hippocampus. Lacosamide treatment after SE mitigated the increased levels of IL-1β and TNF-α in the hippocampus and exerted strong neuroprotection both in the dorsal and ventral hippocampus, basolateral amygdala, and partially in the piriform cortex. Our results suggest that the antioxidant, anti-inflammatory, and neuroprotective activity of LCM is an important prerequisite for its anticonvulsant and beneficial effects on SE-induced behavioral comorbidities.

scholarly journals Dissociable Codes of Odor Quality and Odorant Structure in Human Piriform Cortex

Neuron ◽  
2006 ◽  
Vol 49 (3) ◽  
pp. 467-479 ◽  
Author(s):  
Jay A. Gottfried ◽  
Joel S. Winston ◽  
Raymond J. Dolan
Keyword(s):  
Piriform Cortex ◽  
Odor Quality

Immunocytochemical analysis of basket cells in rat piriform cortex

2001 ◽  
Vol 434 (3) ◽  
pp. 308-328 ◽  
Author(s):  
Jeffrey J. Ekstrand ◽  
Mark E. Domroese ◽  
Sherry L. Feig ◽  
Kurt R. Illig ◽  
Lewis B. Haberly
Keyword(s):  
Piriform Cortex ◽  
Immunocytochemical Analysis ◽  
Basket Cells

Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus

2010 ◽  
Vol 518 (22) ◽  
pp. 4612-4628 ◽  
Author(s):  
Ji-Eun Kim ◽  
Seong-Il Yeo ◽  
Hea Jin Ryu ◽  
Min-Ju Kim ◽  
Duk-Soo Kim ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Piriform Cortex ◽  
Edema Formation

scholarly journals Asymmetrical Processing of Olfactory Input in the Piriform Cortex Mediates “Activation” of the Avian Navigation Circuitry

2016 ◽  
Vol 41 (9) ◽  
pp. 745-754 ◽  
Author(s):  
Paulo E. Jorge ◽  
Paulo A.M. Marques ◽  
Belmiro V. Pinto ◽  
John B. Phillips
Keyword(s):  
Piriform Cortex ◽  
Olfactory Input ◽  
Avian Navigation

Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures

2015 ◽  
Vol 53 (3) ◽  
pp. 1782-1793 ◽  
Author(s):  
Hao Wu ◽  
Chao Wang ◽  
Bei Liu ◽  
Huanfa Li ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Ion Channel ◽  
Expression Pattern ◽  
Piriform Cortex ◽  
Altered Expression ◽  
Altered Expression Pattern
Sign in / Sign up

Export Citation Format

Share Document