Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill

2010 ◽  
Vol 48 (3) ◽  
pp. 807-813 ◽  
Author(s):  
Jong-Hwan Kim ◽  
Young-Whan Choi ◽  
Cheol Park ◽  
Cheng-Yun Jin ◽  
You Jin Lee ◽  
...  
Keyword(s):  
Human Leukemia ◽  
U937 Cells ◽  
Apoptosis Induction ◽  
Schizandra Chinensis ◽  
Gomisin N

scholarly journals Apoptosis Induction by Methanol Extract of Prunus mume Fruits in Human Leukemia U937 Cells

2011 ◽  
Vol 21 (8) ◽  
pp. 1109-1119 ◽  
Author(s):  
You-Jeong Chung ◽  
Cheol Park ◽  
Yong-Kee Jeong ◽  
Yung-Hyun Choi
Keyword(s):  
Methanol Extract ◽  
Human Leukemia ◽  
U937 Cells ◽  
Prunus Mume ◽  
Apoptosis Induction

The Nicotinic Acid-p-Aminophenylalanine-Hydroxybenzoic Acid Triads Induce Apoptosis in Human Leukemia U937 Cells

Heterocycles ◽  
2007 ◽  
Vol 71 (7) ◽  
pp. 1503 ◽  
Author(s):  
Akira Katoh ◽  
Mika Yamaguchi ◽  
Ryota Saito ◽  
Keiichiro Utsumi ◽  
Akira Ochiai ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Hydroxybenzoic Acid ◽  
Human Leukemia ◽  
U937 Cells

scholarly journals A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1479 ◽  
Author(s):  
Katarzyna Gach-Janczak ◽  
Joanna Drogosz-Stachowicz ◽  
Angelika Długosz-Pokorska ◽  
Rafał Jakubowski ◽  
Tomasz Janecki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Anticancer Agents ◽  
Biologically Active ◽  
Human Leukemia ◽  
Apoptosis Induction ◽  
Hybrid Compound ◽  
Drug Candidates ◽  
Natural Substances ◽  
High Cytotoxic Activity ◽  
Induced Apoptosis

In the search for new drug candidates, researchers turn to natural substances isolated from plants which may be either used directly or may serve as a source for chemical modifications. An interesting strategy in the design of novel anticancer agents is based on the conjugation of two or more biologically active structural motifs into one hybrid compound. In this study, we investigated the anticancer potential of 4-benzyl-5,7-dimethoxy-4-methyl-3-methylidene-3,4-dihydro-2H-chroman-2-one (DL-247), a new hybrid molecule combining a chroman-2-one skeleton with an exo-methylidene bond conjugated with a carbonyl group, in human myeloid leukemia HL-60 cell line. The cytotoxicity of the new compound was tested using MTT assay. The effect of DL-247 on cell proliferation and apoptosis induction were studied by flow cytometry, fluorometric assay and ELISA analysis. DL-247 displayed high cytotoxic activity (IC50 = 1.15 µM, after 24 h incubation), significantly inhibited cell proliferation and induced apoptosis by both, the intrinsic and extrinsic pathways. A combination of DL-247 with taxol exhibited a strong synergistic effect on DNA damage generation, apoptosis induction and inhibition of cell growth.

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