scholarly journals Caffeic acid treatment alters the extracellular adenine nucleotide hydrolysis in platelets and lymphocytes of adult rats

2013 ◽  
Vol 56 ◽  
pp. 459-466 ◽  
Author(s):  
Javed Anwar ◽  
Roselia Maria Spanevello ◽  
Victor Camera Pimentel ◽  
Jessié Gutierres ◽  
Gustavo Thomé ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Acid Treatment ◽  
Adenine Nucleotide ◽  
Adult Rats ◽  
Nucleotide Hydrolysis

The effect of ebselen on adenine nucleotide hydrolysis by platelets from adult rats

2004 ◽  
Vol 148 (1-2) ◽  
pp. 93-99 ◽  
Author(s):  
Cristina Ribas Fürstenau ◽  
Ana Paula Spier ◽  
Bárbara Rücker ◽  
Simone Luisa Berti ◽  
Ana Maria Oliveira Battastini ◽  
...  
Keyword(s):  
Adenine Nucleotide ◽  
Adult Rats ◽  
Nucleotide Hydrolysis

Previous treatment with ebselen and vitamin E alters adenine nucleotide hydrolysis in platelets from adult rats experimentally demyelinated with ethidium bromide

Life Sciences ◽  
2007 ◽  
Vol 81 (3) ◽  
pp. 241-248 ◽  
Author(s):  
Cinthia M. Mazzanti ◽  
Roselia M. Spanevello ◽  
André Morsch ◽  
Rafael Zanin ◽  
Vanessa Battisti ◽  
...  
Keyword(s):  
Vitamin E ◽  
Ethidium Bromide ◽  
Adenine Nucleotide ◽  
Previous Treatment ◽  
Adult Rats ◽  
Nucleotide Hydrolysis

Effects In Vitro of Guanidinoacetate on Adenine Nucleotide Hydrolysis and Acetylcholinesterase Activity in Tissues from Adult Rats

2008 ◽  
Vol 33 (6) ◽  
pp. 1129-1137 ◽  
Author(s):  
Roselia Maria Spanevello ◽  
Angela Terezinha de Souza Wyse ◽  
Cinthia Melazzo Mazzanti ◽  
Roberta Schmatz ◽  
Naiara Stefanello ◽  
...  
Keyword(s):  
Adenine Nucleotide ◽  
Acetylcholinesterase Activity ◽  
Adult Rats ◽  
Nucleotide Hydrolysis

scholarly journals In female rat heart mitochondria, oophorectomy results in loss of oxidative phosphorylation

2017 ◽  
Vol 232 (2) ◽  
pp. 221-235 ◽  
Author(s):  
Natalia Pavón ◽  
Alfredo Cabrera-Orefice ◽  
Juan Carlos Gallardo-Pérez ◽  
Cristina Uribe-Alvarez ◽  
Nadia A Rivero-Segura ◽  
...  
Keyword(s):  
Rat Heart ◽  
Complex I ◽  
Adenine Nucleotide ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Enzymes ◽  
Female Rat ◽  
Adult Rats ◽  
Mitochondrial Alterations ◽  
Rat Heart Mitochondria ◽  
Estrogen Depletion

Oophorectomy in adult rats affected cardiac mitochondrial function. Progression of mitochondrial alterations was assessed at one, two and three months after surgery: at one month, very slight changes were observed, which increased at two and three months. Gradual effects included decrease in the rates of oxygen consumption and in respiratory uncoupling in the presence of complex I substrates, as well as compromised Ca2+ buffering ability. Malondialdehyde concentration increased, whereas the ROS-detoxifying enzyme Mn2+ superoxide dismutase (MnSOD) and aconitase lost activity. In the mitochondrial respiratory chain, the concentration and activity of complex I and complex IV decreased. Among other mitochondrial enzymes and transporters, adenine nucleotide carrier and glutaminase decreased. 2-Oxoglutarate dehydrogenase and pyruvate dehydrogenase also decreased. Data strongly suggest that in the female rat heart, estrogen depletion leads to progressive, severe mitochondrial dysfunction.

Hyperthyroid adult rat cardiomyocytes. I. Nucleotide content, beta- and alpha-adrenoreceptors, and cAMP production

1989 ◽  
Vol 257 (5) ◽  
pp. C948-C956 ◽  
Author(s):  
C. M. Hohl ◽  
S. Wetzel ◽  
R. H. Fertel ◽  
D. K. Wimsatt ◽  
G. P. Brierley ◽  
...  
Keyword(s):  
Ventricular Myocytes ◽  
Adenine Nucleotide ◽  
Phosphodiesterase Inhibitor ◽  
Cardiac Cells ◽  
Beta Agonist ◽  
Camp Production ◽  
Adult Rats ◽  
Rat Cardiomyocytes ◽  
Adult Rat ◽  
Half Maximal Effective Concentration

Ventricular myocytes isolated from the hypertrophied hearts of thyrotoxic adult rats have an increase in mean protein content per myocyte (6.3 +/- 0.2 vs. 4.4 +/- 0.2 ng) compared with euthyroid cells. Viability and adenine nucleotide profiles are similar in both populations, but NAD content of the hyperthyroid myocytes is depressed (4.9 +/- 0.2 vs. 5.5 +/- 0.2 nmol/mg for controls) and UTP is higher (1.2 +/- 0.09 vs. 0.9 +/- 0.04 nmol/mg). Binding of (-)-[125I]iodocyanopindolol to intact hyperthyroid myocytes is increased by 42% compared with controls, with no change in the dissociation constant (Kd). This elevation in beta-receptor number is correlated to enhanced beta-agonist-induced adenosine 3',5'-cyclic monophosphate (cAMP) production. The half-maximal effective concentration (EC50) for the euthyroid isoproterenol dose-response curve is 2.14 x 10(-7) M but is decreased to 2.51 x 10(-8) M in hyperthyroid cardiac cells. Basal adenylate cyclase activity is apparently not affected by thyroid hormones, since basal cAMP levels for both groups are identical (5 pmol/mg) and both rise roughly twofold in the presence of a phosphodiesterase inhibitor. Forskolin-induced cAMP production and cAMP-specific phosphodiesterase activity are similar as well. In contrast to beta-adrenergic response, there are no significant differences in alpha 1-antagonist [3H]prazosin binding parameters between hyperthyroid and euthyroid cardiomyocytes.

Chronic stress effects on adenine nucleotide hydrolysis in the blood serum and brain structures of rats

2002 ◽  
Vol 74 (1) ◽  
pp. 181-186 ◽  
Author(s):  
Iraci Lucena S Torres ◽  
Andreia Buffon ◽  
Giovana Dantas ◽  
Cristina Ribas Fürstenau ◽  
Ana Elisa Böhmer ◽  
...  
Keyword(s):  
Blood Serum ◽  
Chronic Stress ◽  
Adenine Nucleotide ◽  
Brain Structures ◽  
Nucleotide Hydrolysis ◽  
Stress Effects

Mechanical and metabolic alterations in rat diaphragm during electrical stimulation

1989 ◽  
Vol 67 (1) ◽  
pp. 210-220 ◽  
Author(s):  
P. S. Massarelli ◽  
H. J. Green ◽  
R. L. Hughson ◽  
M. T. Sharratt
Keyword(s):  
Duty Cycle ◽  
Adenine Nucleotide ◽  
Isometric Force ◽  
Low Frequency ◽  
Maximal Velocity ◽  
Force Output ◽  
Experimental Conditions ◽  
Adult Rats ◽  
Male Adult ◽  
Fatigue Development

To investigate the hypothesis that the rate of fatigue development is not influenced by the absolute duration of contraction (train duration) and relaxation (off-phase of duty cycle) at constant duty cycle, strips of the diaphragm from 36 male adult rats (mean +/- SD wt 152 +/- 21 g) were stimulated directly for periods of 180, 250, and 320 ms at a constant duty cycle of 50%. The frequency of stimulation was adjusted to produce 40% of maximal tetanic tension at supramaximal voltages. After 30 min of stimulation, analysis of twitch characteristics between control and experimental groups indicated a prolongation of contraction time of 9% (P less than 0.05), an increase in relaxation time of 75% (P less than 0.05), and a decrease in twitch tension by 78% (P less than 0.05). Similarly, reductions (P less than 0.05) in isometric force output at high stimulation frequency (100 Hz) of 58% and at low frequency (20 Hz) of 67% were also noted. These changes were accompanied by an approximately 60% reduction in the maximal velocity of shortening. No difference was observed for any of the mechanical measures between experimental conditions. After 30-min stimulation, decreases of between 43 and 46% were noted for ATP (P less than 0.05) and increases of between three- and fourfold noted for IMP (P less than 0.05). No changes were found for either ADP or AMP. Total adenine nucleotide concentrations declined (P less than 0.05) an average of 24%. As with the mechanical data, no differences were found between the different stimulation conditions. It is concluded that for the conditions studied, fatigue mechanisms become manifest early in the stimulation period and are only minimally altered by the duration of specific contractions provided the relaxation period is of equal duration.

Ovariectomy and estradiol replacement therapy alters the adenine nucleotide hydrolysis in rat blood serum

2004 ◽  
Vol 114 (4) ◽  
pp. 275-281 ◽  
Author(s):  
Daniela Pochmann ◽  
Bárbara Rücker ◽  
Ana M.O. Battastini ◽  
João J.F. Sarkis
Keyword(s):  
Blood Serum ◽  
Replacement Therapy ◽  
Adenine Nucleotide ◽  
Nucleotide Hydrolysis ◽  
Rat Blood

Long-Term Zoledronic Acid Treatment Increases Bone Structure and Mechanical Strength of Long Bones of Ovariectomized Adult Rats

2003 ◽  
Vol 72 (4) ◽  
pp. 519-527 ◽  
Author(s):  
S.B. Hornby ◽  
G.P. Evans ◽  
S.L. Hornby ◽  
A. Pataki ◽  
M. Glatt ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Mechanical Strength ◽  
Acid Treatment ◽  
Bone Structure ◽  
Long Bones ◽  
Adult Rats ◽  
Ovariectomized Adult Rats

Decrease of serum adenine nucleotide hydrolysis in an irritant contact dermatitis mice model: potential P2X7R involvement

2015 ◽  
Vol 404 (1-2) ◽  
pp. 221-228 ◽  
Author(s):  
R. F. Zanin ◽  
G. L. da Silva ◽  
T. Erig ◽  
N. D. M. Sperotto ◽  
C. E. Leite ◽  
...  
Keyword(s):  
Contact Dermatitis ◽  
Adenine Nucleotide ◽  
Model Potential ◽  
Irritant Contact Dermatitis ◽  
Mice Model ◽  
Nucleotide Hydrolysis
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