Characterization of phenolic extracts from Brava extra virgin olive oils and their cytotoxic effects on MCF-7 breast cancer cells

2018 ◽  
Vol 119 ◽  
pp. 73-85 ◽  
Author(s):  
Patricia Reboredo-Rodríguez ◽  
Carmen González-Barreiro ◽  
Beatriz Cancho-Grande ◽  
Tamara Y. Forbes-Hernández ◽  
Massimiliano Gasparrini ◽  
...  
2017 ◽  
Author(s):  
I. A. Zamulaeva ◽  
O. N. Matchuk ◽  
K. A. Churyukina ◽  
V. A. Kudryavtzev ◽  
N. G. Yabbarov ◽  
...  

2017 ◽  
Vol 45 (8) ◽  
pp. 1769-1777 ◽  
Author(s):  
Mohammad Hossein Abdolmohammadi ◽  
Faranak Fallahian ◽  
Zahra Fakhroueian ◽  
Mozhgan Kamalian ◽  
Peyman Keyhanvar ◽  
...  

2010 ◽  
Vol 88 (12) ◽  
pp. 1172-1180 ◽  
Author(s):  
Melanie Heney ◽  
Misagh Alipour ◽  
Dimitrios Vergidis ◽  
Abdelwahab Omri ◽  
Clement Mugabe ◽  
...  

Paclitaxel is an effective chemotherapeutic agent that is widely used for the treatment of several cancers, including breast, ovarian, and non-small-cell lung cancer. Due to its high lipophilicity, paclitaxel is difficult to administer and requires solubilization with Cremophor EL (polyethoxylated castor oil) and ethanol, which often lead to adverse side effects, including life-threatening anaphylaxis. Incorporation of paclitaxel in dimyristoylphosphatidylcholine:dimyristoylphosphatidylglycerol (DPPC:DMPG) liposomes can facilitate its delivery to cancer cells and eliminate the adverse reactions associated with the Cremophor EL vehicle. Accordingly, the effectiveness of liposomal paclitaxel on MCF-7 breast cancer cells was examined. The results from this study showed that (i) the lipid components of the liposomal formulation were nontoxic, (ii) the cytotoxic effects of liposomal paclitaxel were improved when compared with those seen with conventional paclitaxel, and (iii) the intracellular paclitaxel levels were higher in MCF-7 cells treated with the liposomal paclitaxel formulation. The results of these studies showed that delivery of paclitaxel as a liposomal formulation could be a promising strategy for enhancing its chemotherapeutic effects.


2019 ◽  
Vol 37 (11) ◽  
pp. 1183-1187 ◽  
Author(s):  
Ha Thi Phuong ◽  
Tran Thu Huong ◽  
Le Thi Vinh ◽  
Hoang Thi Khuyen ◽  
Do Thi Thao ◽  
...  

1995 ◽  
Vol 79 (3) ◽  
pp. 261-274 ◽  
Author(s):  
Leslie Oleksowicz ◽  
Zbigniew Mrowiec ◽  
Edward Schwartz ◽  
Manoochehr Khorshidi ◽  
Janice P. Dutcher ◽  
...  

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