EFFECTS OF VITAMIN D ADMINISTRATION IN THE MOUSE MODEL OF POLYCYSTIC OVARIAN SYNDROME

Objective: Polycystic ovarian syndrome (PCOS) is a common cause of ovarian dysfunction in women in reproductive age group. It is now the leading cause of infertility among premenopausal women. PCOS women usually suffer from metabolic disturbances and insulin resistance (IR). Vitamin D has shown a significant role in glucose and insulin metabolism. Correlation studies have been done to examine the role of vitamin D in PCOS. However, still, Vitamin D status in PCOS remains varied. This study is an attempt to find out the association of Vitamin D with etiopathogenesis and metabolic risk factors seen in PCOS. Methods: Hundred subjects (50 PCOS and 50 age-matched normal control) were recruited for the study. Difference in biochemical parameters in PCOS women and normal group was measured, and association of Vitamin D with etiological and biochemical parameters in PCOS was seen. Results: There was a significant (p<0.001) increase in body mass index, serum insulin, fasting blood sugar (FBS), serum cholesterol, triglyceride, and low-density lipoprotein in PCOS. IR was observed in PCOS cases (homeostatic model assessment for β-cell function and IR = 6.40±1.96) compared to the control group (2.43±0.53). Serum 25(OH) Vitamin D3 was significantly decreased in PCOS (9.04±2.60 ng/ml) compared to control group (20.06±3.28 ng/ml). Negative correlation of serum Vitamin D was found with FBS, serum insulin, IR, HI, and serum testosterone. Vitamin D with metabolic parameters also showed a statistically significant negative correlation. Conclusion: Vitamin D deficiency may be a common comorbid manifestation of PCOS. Hence, Vitamin D supplementation may decrease the potential risk of morbidity and mortality associated with PCOS. However, further studies are needed which should include assessment of Vitamin D in women at various stages of PCOS to enhance the temporal order of Vitamin D deficiency in relation to PCOS.

Download Full-text

Suplementasi Vitamin D pada Wanita dengan Polycystic Ovarian Syndrome (PCOS)

Jurnal Ilmiah Kesehatan Sandi Husada ◽

10.35816/jiskh.v10i2.140 ◽

2019 ◽

Vol 8 (2) ◽

pp. 169-177

Author(s):

Dian octaviana Aziza ◽

Karin Indah Kurniati

Keyword(s):

Vitamin D ◽

Polycystic Ovarian Syndrome ◽

Ovarian Syndrome

Polycyctic Ovarian Syndrome (PCOS) adalah penyebab paling sering terjadinya anovulasi dan infertilitas anovulasi. PCOS dapat dikatakan endokrinopati yang sering terjadi pada wanita dengan usia subur dan berkaitan dengan kelainan metabolik dan disfungsi reproduksi. Apabila tidak dilakukan manajemen terapi pada wanita dengan PCOS dapat terjadi komplikasi. Beberapa studi percontohan menilai efikasi terapeutik vitamin D dalam parameter metabolik terkait PCOS. Vitamin D adalah hormon steroid esensial yang berperan dalam menjaga hemostasis kalsium dan fosfat. Konsentrasi vitamin D dalam serum dinyatakan kurang jika kadar 25(OH)D 21-29 ng/mL dan dinyatakan defisiensi vitamin D jika kadar 25(OH)D <20 ng/mL. Efek defisiensi vitamin D yang dapat terjadi gangguan fertilitas dan menstruasi serta efek negatif pada sistem kardiovaskuler. Vitamin D memiliki efek langsung pada proses folikulogenesis dan maturasi oosit. Steroidogenesis dalam ovarium yang menghasilkan progesteron, estradiol dan estron dibantu calcitriol (vitamin D). Suplementasi vitamin D pada wanita dengan PCOS menunjukkan peningkatan kerja sel granulosa yakni sekresi progesteron meningkat.

Download Full-text