scholarly journals Relation of Vitamin D Deficiency in Women with Polycystic Ovarian Syndrome in Kirkuk Province

2019 ◽  
Vol 3 (1) ◽  
pp. 1-8
Author(s):  
Al-Zahraa Mohammed Sulaiman ◽  
Kafiah Raoof Rahed ◽  
Tariq Abdulahmeed Midhat
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals ROLE OF VITAMIN D IN ETIOPATHOGENESIS AND METABOLIC ABNORMALITIES SEEN IN POLYCYSTIC OVARIAN SYNDROME

2019 ◽  
pp. 215-219
Author(s):  
SURANKITA SUKUL ◽  
JYOTIRMAYEE BAHINIPATI ◽  
ASHOK KUMAR DAS
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Biochemical Parameters ◽  
Polycystic Ovarian Syndrome ◽  
Serum Insulin ◽  
Control Group ◽  
Insulin Metabolism ◽  
Ovarian Syndrome

Objective: Polycystic ovarian syndrome (PCOS) is a common cause of ovarian dysfunction in women in reproductive age group. It is now the leading cause of infertility among premenopausal women. PCOS women usually suffer from metabolic disturbances and insulin resistance (IR). Vitamin D has shown a significant role in glucose and insulin metabolism. Correlation studies have been done to examine the role of vitamin D in PCOS. However, still, Vitamin D status in PCOS remains varied. This study is an attempt to find out the association of Vitamin D with etiopathogenesis and metabolic risk factors seen in PCOS. Methods: Hundred subjects (50 PCOS and 50 age-matched normal control) were recruited for the study. Difference in biochemical parameters in PCOS women and normal group was measured, and association of Vitamin D with etiological and biochemical parameters in PCOS was seen. Results: There was a significant (p<0.001) increase in body mass index, serum insulin, fasting blood sugar (FBS), serum cholesterol, triglyceride, and low-density lipoprotein in PCOS. IR was observed in PCOS cases (homeostatic model assessment for β-cell function and IR = 6.40±1.96) compared to the control group (2.43±0.53). Serum 25(OH) Vitamin D3 was significantly decreased in PCOS (9.04±2.60 ng/ml) compared to control group (20.06±3.28 ng/ml). Negative correlation of serum Vitamin D was found with FBS, serum insulin, IR, HI, and serum testosterone. Vitamin D with metabolic parameters also showed a statistically significant negative correlation. Conclusion: Vitamin D deficiency may be a common comorbid manifestation of PCOS. Hence, Vitamin D supplementation may decrease the potential risk of morbidity and mortality associated with PCOS. However, further studies are needed which should include assessment of Vitamin D in women at various stages of PCOS to enhance the temporal order of Vitamin D deficiency in relation to PCOS.

8. Level of Anti-Müllerian Hormone and the Association of Vitamin D Deficiency with Polycystic Ovarian Syndrome in Adolescent Females

2020 ◽  
Vol 33 (2) ◽  
pp. 241-242
Author(s):  
Samantha Simpson ◽  
David Seifer ◽  
Veronika Shabanova ◽  
Anna Lynn ◽  
Catherine Howe ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovarian Syndrome ◽  
Adolescent Females ◽  
Ovarian Syndrome

scholarly journals Genotype-independent association between vitamin D deficiency and polycystic ovarian syndrome in Lahore, Pakistan

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nasira M. Lone ◽  
Saba Riaz ◽  
Amna Z. Eusaph ◽  
Charles A. Mein ◽  
Eva L. Wozniak ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovarian Syndrome ◽  
Independent Association ◽  
Ovarian Syndrome

Comparison of 25-hydroxyvitamin D and metabolic parameters between women with and without polycystic ovarian syndrome

2017 ◽  
Vol 31 (3) ◽  
Author(s):  
Beng Kwang Ng ◽  
Chui Ling Lee ◽  
Pei Shan Lim ◽  
Hanita Othman ◽  
Nor Azlin Mohamed Ismail
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovarian Syndrome ◽  
Density Lipoprotein ◽  
Control Group ◽  
Study Group ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Ovarian Syndrome

AbstractBackgroundThere is increasing evidence that supports the contribution of vitamin D deficiency in metabolic disturbances among women with polycystic ovarian syndrome (PCOS). The aim of this study was to compare 25-hydroxyvitamin D level and the prevalence of metabolic syndrome in the PCOS and normal women.Materials and methodsA case-controlled study was conducted in a teaching hospital over a 6-month duration from June 2015 to January 2016. A total of 90 women, who consisted of 45 women with PCOS (study group) and 45 women without PCOS (control group), were recruited.ResultsThe final analysis was of 80 women only and the prevalence of vitamin D deficiency (<20 ng/mL) was high between both groups, i.e. 93.7% but there was no significant difference (p = 0.874). Nevertheless, the prevalence of metabolic syndrome was significantly higher in the study group as compared to the control group (27.5% vs. 5.0%, p = 0.013). There was no statistically significant correlation between vitamin D level with clinical [age, weight, body mass index (BMI), waist and hip circumference, systolic and diastolic blood pressure (SBP and DPB, respectively)] and metabolic parameters (fasting glucose, triglycerides, cholesterol, high-density lipoprotein and low-density lipoprotein) among women with PCOS. However, height was positively correlated (r = 0.338, p = 0.033) and the contrary waist-hip ratio was negatively correlated with vitamin D level (r = −0.605, p = 0.048).ConclusionThe prevalence of vitamin D deficiency was high in our study population. Nevertheless, the prevalence of metabolic syndrome was higher among women with PCOS as compared to women without PCOS.

scholarly journals EFFECTS OF VITAMIN D ADMINISTRATION IN THE MOUSE MODEL OF POLYCYSTIC OVARIAN SYNDROME

2020 ◽  
Vol 114 (3) ◽  
pp. e406
Author(s):  
Huiling Xu ◽  
Shumin Qiu ◽  
Peiyang Lin ◽  
Xiuhua Liao ◽  
Beihong Zheng
Keyword(s):  
Vitamin D ◽  
Mouse Model ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Suplementasi Vitamin D pada Wanita dengan Polycystic Ovarian Syndrome (PCOS)

2019 ◽  
Vol 8 (2) ◽  
pp. 169-177
Author(s):  
Dian octaviana Aziza ◽  
Karin Indah Kurniati
Keyword(s):  
Vitamin D ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

Polycyctic Ovarian Syndrome (PCOS) adalah penyebab paling sering terjadinya anovulasi dan infertilitas anovulasi. PCOS dapat dikatakan endokrinopati yang sering terjadi pada wanita dengan usia subur dan berkaitan dengan kelainan metabolik dan disfungsi reproduksi. Apabila tidak dilakukan manajemen terapi pada wanita dengan PCOS dapat terjadi komplikasi. Beberapa studi percontohan menilai efikasi terapeutik vitamin D dalam parameter metabolik terkait PCOS. Vitamin D adalah hormon steroid esensial yang berperan dalam menjaga hemostasis kalsium dan fosfat.  Konsentrasi vitamin D dalam serum dinyatakan kurang jika kadar 25(OH)D 21-29 ng/mL dan dinyatakan defisiensi vitamin D jika  kadar 25(OH)D <20 ng/mL. Efek defisiensi vitamin D yang dapat terjadi gangguan fertilitas dan menstruasi serta efek negatif pada sistem kardiovaskuler. Vitamin D memiliki efek langsung pada proses folikulogenesis dan maturasi oosit. Steroidogenesis dalam ovarium yang menghasilkan  progesteron, estradiol dan estron dibantu calcitriol (vitamin D). Suplementasi vitamin D pada wanita dengan PCOS menunjukkan peningkatan kerja sel granulosa yakni sekresi progesteron meningkat.

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