A critical review on therapeutic potential of vitamin D mediated suppression of miRNA222 associated metabolic defect in polycystic ovarian syndrome

2021 ◽  
Author(s):  
Waleed Hassan almalki ◽  
Abdulaziz Alzahrani ◽  
Mahmoud El-Sayed Mahmoud El-Daly ◽  
AL- S Haimaa Faissal Fadel Ahmed
Keyword(s):  
Vitamin D ◽  
Critical Review ◽  
Polycystic Ovarian Syndrome ◽  
Therapeutic Potential ◽  
Metabolic Defect ◽  
Ovarian Syndrome

scholarly journals EFFECTS OF VITAMIN D ADMINISTRATION IN THE MOUSE MODEL OF POLYCYSTIC OVARIAN SYNDROME

2020 ◽  
Vol 114 (3) ◽  
pp. e406
Author(s):  
Huiling Xu ◽  
Shumin Qiu ◽  
Peiyang Lin ◽  
Xiuhua Liao ◽  
Beihong Zheng
Keyword(s):  
Vitamin D ◽  
Mouse Model ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals ROLE OF VITAMIN D IN ETIOPATHOGENESIS AND METABOLIC ABNORMALITIES SEEN IN POLYCYSTIC OVARIAN SYNDROME

2019 ◽  
pp. 215-219
Author(s):  
SURANKITA SUKUL ◽  
JYOTIRMAYEE BAHINIPATI ◽  
ASHOK KUMAR DAS
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Biochemical Parameters ◽  
Polycystic Ovarian Syndrome ◽  
Serum Insulin ◽  
Control Group ◽  
Insulin Metabolism ◽  
Ovarian Syndrome

Objective: Polycystic ovarian syndrome (PCOS) is a common cause of ovarian dysfunction in women in reproductive age group. It is now the leading cause of infertility among premenopausal women. PCOS women usually suffer from metabolic disturbances and insulin resistance (IR). Vitamin D has shown a significant role in glucose and insulin metabolism. Correlation studies have been done to examine the role of vitamin D in PCOS. However, still, Vitamin D status in PCOS remains varied. This study is an attempt to find out the association of Vitamin D with etiopathogenesis and metabolic risk factors seen in PCOS. Methods: Hundred subjects (50 PCOS and 50 age-matched normal control) were recruited for the study. Difference in biochemical parameters in PCOS women and normal group was measured, and association of Vitamin D with etiological and biochemical parameters in PCOS was seen. Results: There was a significant (p<0.001) increase in body mass index, serum insulin, fasting blood sugar (FBS), serum cholesterol, triglyceride, and low-density lipoprotein in PCOS. IR was observed in PCOS cases (homeostatic model assessment for β-cell function and IR = 6.40±1.96) compared to the control group (2.43±0.53). Serum 25(OH) Vitamin D3 was significantly decreased in PCOS (9.04±2.60 ng/ml) compared to control group (20.06±3.28 ng/ml). Negative correlation of serum Vitamin D was found with FBS, serum insulin, IR, HI, and serum testosterone. Vitamin D with metabolic parameters also showed a statistically significant negative correlation. Conclusion: Vitamin D deficiency may be a common comorbid manifestation of PCOS. Hence, Vitamin D supplementation may decrease the potential risk of morbidity and mortality associated with PCOS. However, further studies are needed which should include assessment of Vitamin D in women at various stages of PCOS to enhance the temporal order of Vitamin D deficiency in relation to PCOS.

scholarly journals Contemporary and Traditional Perspectives of Polycystic Ovarian Syndrome (PCOS): A Critical Review

2014 ◽  
Vol 13 (9) ◽  
pp. 89-98
Author(s):  
Dr. Ruta Kadam ◽  
◽  
Dr. Kirtimalini Shinde ◽  
Dr. Rahul Kadam ◽  
Dr.Mrudula Kulkarni ◽  
...  
Keyword(s):  
Critical Review ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Suplementasi Vitamin D pada Wanita dengan Polycystic Ovarian Syndrome (PCOS)

2019 ◽  
Vol 8 (2) ◽  
pp. 169-177
Author(s):  
Dian octaviana Aziza ◽  
Karin Indah Kurniati
Keyword(s):  
Vitamin D ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

Polycyctic Ovarian Syndrome (PCOS) adalah penyebab paling sering terjadinya anovulasi dan infertilitas anovulasi. PCOS dapat dikatakan endokrinopati yang sering terjadi pada wanita dengan usia subur dan berkaitan dengan kelainan metabolik dan disfungsi reproduksi. Apabila tidak dilakukan manajemen terapi pada wanita dengan PCOS dapat terjadi komplikasi. Beberapa studi percontohan menilai efikasi terapeutik vitamin D dalam parameter metabolik terkait PCOS. Vitamin D adalah hormon steroid esensial yang berperan dalam menjaga hemostasis kalsium dan fosfat.  Konsentrasi vitamin D dalam serum dinyatakan kurang jika kadar 25(OH)D 21-29 ng/mL dan dinyatakan defisiensi vitamin D jika  kadar 25(OH)D <20 ng/mL. Efek defisiensi vitamin D yang dapat terjadi gangguan fertilitas dan menstruasi serta efek negatif pada sistem kardiovaskuler. Vitamin D memiliki efek langsung pada proses folikulogenesis dan maturasi oosit. Steroidogenesis dalam ovarium yang menghasilkan  progesteron, estradiol dan estron dibantu calcitriol (vitamin D). Suplementasi vitamin D pada wanita dengan PCOS menunjukkan peningkatan kerja sel granulosa yakni sekresi progesteron meningkat.

scholarly journals PLASMA VITAMIN D LEVEL AMONG WOMEN WITH AND WITHOUT POLYCYSTIC OVARIAN SYNDROME

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Jemilla Abdi ◽  
Derek Redinger ◽  
K Shane Broughton
Keyword(s):  
Vitamin D ◽  
Polycystic Ovarian Syndrome ◽  
Plasma Vitamin ◽  
Ovarian Syndrome

8. Level of Anti-Müllerian Hormone and the Association of Vitamin D Deficiency with Polycystic Ovarian Syndrome in Adolescent Females

2020 ◽  
Vol 33 (2) ◽  
pp. 241-242
Author(s):  
Samantha Simpson ◽  
David Seifer ◽  
Veronika Shabanova ◽  
Anna Lynn ◽  
Catherine Howe ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovarian Syndrome ◽  
Adolescent Females ◽  
Ovarian Syndrome

Vitamin D and calcium dysregulation in the polycystic ovarian syndrome

Steroids ◽  
1999 ◽  
Vol 64 (6) ◽  
pp. 430-435 ◽  
Author(s):  
Susan Thys-Jacobs ◽  
Daniel Donovan ◽  
Anatasio Papadopoulos ◽  
Philip Sarrel ◽  
John P Bilezikian
Keyword(s):  
Vitamin D ◽  
Polycystic Ovarian Syndrome ◽  
Calcium Dysregulation ◽  
Ovarian Syndrome

scholarly journals Relation of Vitamin D Deficiency in Women with Polycystic Ovarian Syndrome in Kirkuk Province

2019 ◽  
Vol 3 (1) ◽  
pp. 1-8
Author(s):  
Al-Zahraa Mohammed Sulaiman ◽  
Kafiah Raoof Rahed ◽  
Tariq Abdulahmeed Midhat
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome
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