ARE THE NUMBER OF BLASTOMERES AT THE CLEAVAGE-STAGE ASSOCIATED WITH ONGOING PREGNANCY FOLLOWING SINGLE BLASTOCYST FROZEN EMBRYO TRANSFERS?

SummaryClinical outcomes following frozen–thawed cleavage embryo transfer versus frozen–thawed blastocyst transfer in high responder patients undergoing in vitro fertilisation/intracytoplasmic sperm injection cycles are still debated. In a retrospective study, 106 high responder patients who were candidate for ‘freeze-all embryos’ were recruited. Frozen–thawed embryos were transferred at the cleavage stage (n = 53) or the blastocyst stage (n = 53). Clinical pregnancy was considered as the primary outcome and chemical pregnancy, ongoing pregnancy, implantation rate, and fertilization rate, as well as miscarriage rate, were measured as the secondary outcome. Clinical (47.2% vs. 24.5%), chemical (56.6% vs. 32.1%), and ongoing pregnancy rates (37.7% vs. 17%) as well as implantation rates (33.6% vs. 13.5%) were significantly higher in the blastocyst group compared with the cleavage group respectively (P < 0.05). Miscarriage rate was comparable between groups (P > 0.05). Transfer of frozen–thawed embryos at the blastocyst stage was preferable in the high responder patients to increase implantation, pregnancy and live birth rates compared with cleavage stage embryo transfer.

Download Full-text

The Effect of Intrauterine Administration of Human Chorionic Gonadotropin (hCG) Before Embryo Transfer During Assisted Reproductive Cycles: a Meta-Analysis of Randomized Controlled Trials

Geburtshilfe und Frauenheilkunde ◽

10.1055/a-0837-3246 ◽

2019 ◽

Vol 79 (07) ◽

pp. 713-722

Author(s):

Huiping Tan ◽

Shifu Hu ◽

Yuan Chen ◽

Lei Jin ◽

Chunlin Wu ◽

...

Keyword(s):

Randomized Controlled Trials ◽

Chorionic Gonadotropin ◽

Human Chorionic Gonadotropin ◽

Meta Analysis ◽

Implantation Rate ◽

Clinical Pregnancy ◽

Controlled Trials ◽

Ongoing Pregnancy ◽

Cleavage Stage ◽

Randomized Controlled

AbstractThe fertility success rates of clinical and laboratory-assisted reproductive techniques (ART) remain low, despite major advances. The aim of this study was to conduct a systematic literature review and assess whether the intrauterine administration of human chorionic gonadotropin (hCG) before embryo transfer (ET) improved the clinical outcomes of sub-fertile women undergoing assisted reproduction. The electronic databases PUBMED, EMBASE and Web of Science were systematically searched for randomized controlled trials (RCTs) published from inception to June 2018. The trial data were independently extracted and analyzed using risk ratios (RRs) and 95% confidence intervals (CIs) according to a random- or fixed-effect model (as appropriate), and a meta-analysis was conducted using Review Manager 5.2 software. The meta-analysis included 3241 patients from 12 RCTs, and the combined results demonstrated that intrauterine hCG injection significantly improved the rates of clinical (RR = 1.33; 95% CI: 1.12 – 1.58) and ongoing pregnancy (RR = 1.87; 95% CI: 1.54 – 2.27), compared with controls. However, intrauterine hCG injection had no significant effect on the implantation rate (RR = 1.30; 95% CI: 0.89 – 1.90), abortion rate (RR = 1.06; 95% CI: 0.78 – 1.44), ectopic pregnancy rate (RR = 0.77; 95% CI: 0.17 – 3.42) or live birth rate (RR = 0.99; 95% CI: 0.60 – 1.63). In a subgroup analysis, the intrauterine injection of > 500 IU hCG led to a significant increase in the implantation rate (RR = 1.64; 95% CI: 1.04 – 2.61) relative to controls. Furthermore, the subgroup of women with cleavage-stage ETs who received an intracavity injection of hCG (IC-hCG) exhibited increases in the implantation, clinical pregnancy and ongoing pregnancy rates, compared to women with cleavage-stage ETs and no IC-hCG. The current evidence indicates that intrauterine hCG administration before ET provides an advantage in terms of the clinical pregnancy and ongoing pregnancy rates.

Download Full-text

Transfer of blastocysts derived from frozen-thawed cleavage stage embryos improved ongoing pregnancy

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-012-2303-9 ◽

2012 ◽

Vol 286 (2) ◽

pp. 511-516 ◽

Cited By ~ 9

Author(s):

Maryam Eftekhar ◽

Abbas Aflatoonian ◽

Farnaz Mohammadian ◽

Nasim Tabibnejad

Keyword(s):

Ongoing Pregnancy ◽

Cleavage Stage

Download Full-text

Is There a Difference in Terms of Perinatal Outcomes Between Fresh and Frozen Embryo Transfers?

Gynecology Obstetrics and Reproductive Medicine ◽

10.21613/gorm.2019.932 ◽

2019 ◽

pp. 1

Author(s):

Ayse Zehra Ozdemir ◽

Pervin Karli

Keyword(s):

Birth Weight ◽

Pregnancy Outcomes ◽

Birth Rate ◽

Live Birth Rate ◽

Ongoing Pregnancy ◽

Vitro Fertilization ◽

Biochemical Pregnancy ◽

Significant Difference ◽

Frozen Embryo Transfers

OBJECTIVE: Nowadays, fresh embryo transfers and frozen embryo transfers are frequently employed in the treatment of in vitro fertilization. This study aims to compare the pregnancy outcomes in patients who underwent fresh embryo transfers and frozen embryo transfers. STUDY DESIGN: All patients who underwent fresh embryo transfers and frozen embryo transfers at the in vitro fertilization center, Ondokuz Mayis University between 2010 and 2017 were screened retrospectively and the pregnancy results were evaluated at one-year follow-up. The study included a total of 912 transfers, 679 of which were fresh embryo transfers and 233 were fresh embryo transfers, in 756 patients. Comparisons were made in terms of biochemical pregnancy, clinical pregnancy rate, ongoing pregnancy, and live birth rate.RESULTS: Ectopic pregnancy, biochemical pregnancy, and abortus in fresh embryo transfers were found to be significantly more than that in frozen embryo transfers (p=0.001). However, no statistically significant difference in terms of clinical or ongoing pregnancy rate or live birth rate was observed. Birth weight was significantly lower in fresh embryo transfers than in frozen embryo transfers (p=0.001, p= 0.031). Multiple pregnancies preeclampsia, preterm labor, and placental abruption did not show a statistically significant difference in fresh embryo transfers and frozen embryo transfers. Yet, gestational diabetes was significantly more in frozen embryo transfers (p=0.011).CONCLUSIONS: Early pregnancy complications in fresh embryo transfers are higher than that in frozen embryo transfers. In terms of neonatal results, higher birth weight and gestational diabetes are more prevalent in frozen embryo transfers. In this study, it has been shown that fresh embryo transfers are more often associated with negative pregnancy outcomes. frozen embryo transfers can be better for pregnancy results

Download Full-text