FERTILITY PRESERVATION BY SPERM BANKING BEFORE GONADOTOXIC TREATMENT: 26 YEARS OF EXPERIENCE

59 Background: Each year nearly 70,000 adolescents and young adults (AYAs) are diagnosed with cancer. Recently, steps have been taken to address infertility, which is an important issue experienced by AYAs. For example, ASCO QOPI includes fertility standards and Walgreens and the LIVESTRONG Foundation provide financial assistance for fertility preservation medications. To better understand the current state of fertility preservation, eight questions on this topic were included on the LIVESTRONG Survey. Methods: From June to December 2012, LIVESTRONG conducted an online survey (N = 6,313). Analysis here includes the 1,333 AYA respondents who were diagnosed since 2002. Results: Only 24% of respondents (42% of males, 12% of females) indicated they took steps to preserve their fertility before beginning treatment. Top reasons for not preserving their fertility were not receiving information about options (19%) and/or information about the risks to their fertility (14%). For the AYAs who did preserve their fertility, the median amount spent on fertility expenses was between $1,000 and $2,499 (Table) with males spending significantly less than females (p < 0.001). Mostly commonly, males used sperm banking (97%) while females used egg and embryo banking (each 35%). The majority all who attempted to become pregnant were successful (58% and 68% respectively). Conclusions: Results from this analysis indicate that few survivors took steps to preserve their fertility before starting treatment. Yet for those who were interested in preserving their fertility and starting a family, the majority of individuals were successful. Many individuals reported not preserving their fertility due to a lack of information or resources. While a relatively small number of survivors will have fertility concerns, this is an important quality of life issue for those who do. [Table: see text]

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Professionals' views on the issues and challenges arising from providing a fertility preservation service through sperm banking to teenage males with cancer

Human Fertility ◽

10.1080/1464727042000198087 ◽

2004 ◽

Vol 7 (1) ◽

pp. 23-30 ◽

Cited By ~ 29

Author(s):

Marilyn Crawshaw ◽

Adam Glaser ◽

Juliet Hale ◽

Patricia Sloper

Keyword(s):

Fertility Preservation ◽

Sperm Banking

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Sperm cryopreservation of male cancer patients for fertility preservation : 10-year monocentric experience

10.21203/rs.3.rs-212790/v1 ◽

2021 ◽

Author(s):

Xiao Liu ◽

Bo Liu ◽

shasha liu ◽

yang xian ◽

wenrui zhao ◽

...

Keyword(s):

Germ Cell ◽

Cancer Patients ◽

Fertility Preservation ◽

Sperm Quality ◽

Germ Cell Tumors ◽

Semen Parameters ◽

Sperm Cryopreservation ◽

Sperm Banking ◽

Hematological Neoplasms ◽

Body Regions

Abstract Background: Semen cryopreservation is an effective method to preserve fertility, which is very important for male cancer patients. Unfortunately, due to unaware of the opportunities for sperm cryopreservation for both physicians and cancer patients, not a lot of data on evaluating the semen parameters and dispositions of the cryopreserved samples of Chinese cancer population are available in the literature. Methods: We retrospectively reviewed semen parameters as well as the clinical outcomes of assisted reproductive treatments (ART) of 339 male cancer patients of Chinese population who were referred to our center from 2010 to 2019 for fertility preservation. Results: We first classify the male tumors into six major types according to body regions. The most prevalent cancer patients who came from our cohort for sperm banking were hematological neoplasms patients, and the second cancers were germ cell tumors. Patients with germ cell tumors had the lowest pre- thaw and post-thaw concentration among the six major cancer types. However, we separately compared among testicular tumors, lymphoma and leukemia, it turned out that leukemia had the lowest pre-thaw concentration. Most cancer patients (58%) chose to go on keeping their specimens in storage. The second proportion selected to discard their specimens electively (31%). Over the years, there were only 13 patients (4%) returned to use their sperm by ART. In the storage samples, germ cell tumors were the most proportion ones (29.3%). Moreover, in the unfrozen samples, the percentage of hematological neoplasms were the most (45.5%).Conclusions: To our knowledge, we had owned the most numbers of male cancers who came to sperm bank for fertility conservation in the southwest of China. In our study we suggested that sperm quality could decrease even before antineoplastic treatment and sperm banking prior to treatment should be strongly recommended for male cancer patients.

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Ovarian tissue cryopreservation for fertility preservation in 418 girls and adolescents up to 15 years of age facing highly gonadotoxic treatment. Twenty years of experience at a single center

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1111/aogs.13616 ◽

2019 ◽

Vol 98 (5) ◽

pp. 630-637 ◽

Cited By ~ 9

Author(s):

Catherine Poirot ◽

Laurence Brugieres ◽

Karima Yakouben ◽

Marie Prades‐Borio ◽

Flora Marzouk ◽

...

Keyword(s):

Fertility Preservation ◽

Ovarian Tissue ◽

Ovarian Tissue Cryopreservation ◽

Years Of Experience ◽

Single Center ◽

Tissue Cryopreservation

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Prevalence and Predictors of Sperm Banking in Adolescents Newly Diagnosed With Cancer: Examination of Adolescent, Parent, and Provider Factors Influencing Fertility Preservation Outcomes

Journal of Clinical Oncology ◽

10.1200/jco.2016.70.4767 ◽

2017 ◽

Vol 35 (34) ◽

pp. 3830-3836 ◽

Cited By ~ 38

Author(s):

James L. Klosky ◽

Fang Wang ◽

Kathryn M. Russell ◽

Hui Zhang ◽

Jessica S. Flynn ◽

...

Keyword(s):

Fertility Preservation ◽

Psychological Health ◽

Tanner Stage ◽

The United States ◽

Adolescent Males ◽

Self Report ◽

Newly Diagnosed ◽

Sperm Banking ◽

Factors Associated ◽

Adolescent Parent

Purpose To estimate the prevalence of sperm banking among adolescent males newly diagnosed with cancer and to identify factors associated with banking outcomes. Patients and Methods A prospective, single-group, observational study design was used to test the contribution of sociodemographic, medical, psychological/health belief, communication, and developmental factors to fertility preservation outcomes. At-risk adolescent males (N = 146; age 13.00 to 21.99 years; Tanner stage ≥ 3), their parents, and medical providers from eight leading pediatric oncology centers across the United States and Canada completed self-report questionnaires within 1 week of treatment initiation. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% CIs for specified banking outcomes (collection attempt v no attempt and successful completion of banking v no banking). Results Among adolescents (mean age, 16.49 years; standard deviation, 2.02 years), 53.4% (78 of 146) made a collection attempt, with 43.8% (64 of 146) successfully banking sperm (82.1% of attempters). The overall attempt model revealed adolescent consultation with a fertility specialist (OR, 29.96; 95% CI, 2.48 to 361.41; P = .007), parent recommendation to bank (OR, 12.30; 95% CI, 2.01 to 75.94; P = .007), and higher Tanner stage (OR, 5.42; 95% CI, 1.75 to 16.78; P = .003) were associated with an increased likelihood of a collection attempt. Adolescent history of masturbation (OR, 5.99; 95% CI, 1.25 to 28.50; P = .025), banking self-efficacy (OR, 1.23; 95% CI, 1.05 to 1.45; P = .012), and parent (OR, 4.62; 95% CI, 1.46 to 14.73; P = .010) or medical team (OR, 4.26; 95% CI, 1.45 to 12.43; P = .008) recommendation to bank were associated with increased likelihood of sperm banking completion. Conclusion Although findings suggest that banking is underutilized, modifiable adolescent, parent, and provider factors associated with banking outcomes were identified and should be targeted in future intervention efforts.

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