Baicalein decreases side population proportion via inhibition of ABCG2 in multiple myeloma cell line RPMI 8226 in vitro

Fitoterapia ◽  
2014 ◽  
Vol 94 ◽  
pp. 21-28 ◽  
Author(s):  
Yue-Yu Gu ◽  
Li-Ping Liu ◽  
Jian Qin ◽  
Meng Zhang ◽  
Yuling Chen ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Side Population ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Population Proportion ◽  
Multiple Myeloma Cell ◽  
Rpmi 8226

Simvastatin Induces Death of Multiple Myeloma Cell Lines

2004 ◽  
Vol 52 (5) ◽  
pp. 335-344 ◽  
Author(s):  
Naomi Gronich ◽  
Liat Drucker ◽  
Hava Shapiro ◽  
Judith Radnay ◽  
Shai Yarkoni ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Multiple Myeloma ◽  
Cell Death ◽  
Cell Lines ◽  
Myeloma Cell ◽  
Cytoplasmic Calcium ◽  
Multiple Myeloma Cell ◽  
Cycle Arrest ◽  
Rpmi 8226

BackgroundAccumulating reports indicate that statins widely prescribed for hypercholesteromia have antineoplastic activity. We hypothesized that because statins inhibit farnesylation of Ras that is often mutated in multiple myeloma (MM), as well as the production of interleukin (IL)-6, a key cytokine in MM, they may have antiproliferative and/or proapoptotic effects in this malignancy.MethodsU266, RPMI 8226, and ARH77 were treated with simvastatin (0-30 μM) for 5 days. The following aspects were evaluated: viability (IC50), cell cycle, cell death, cytoplasmic calcium ion levels, supernatant IL-6 levels, and tyrosine kinase activity.ResultsExposure of all cell lines to simvastatin resulted in reduced viability with IC50s of 4.5 μM for ARH77, 8 μM for RPMI 8226, and 13 μM for U266. The decreased viability is attributed to cell-cycle arrest (U266, G1; RPMI 8226, G2M) and cell death. ARH77 underwent apoptosis, whereas U266 and RPMI 8226 displayed a more necrotic form of death. Cytoplasmic calcium levels decreased significantly in all treated cell lines. IL-6 secretion from U266 cells was abrogated on treatment with simvastatin, whereas total tyrosine phosphorylation was unaffected.ConclusionsSimvastatin displays significant antimyeloma activity in vitro. Further research is warranted for elucidation of the modulated molecular pathways and clinical relevance.

Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R

2009 ◽  
Vol 89 (4) ◽  
pp. 399-404 ◽  
Author(s):  
Hui Xiao ◽  
Qi Xiao ◽  
Kejian Zhang ◽  
Xuelan Zuo ◽  
Umid Kumar Shrestha
Keyword(s):  
Multiple Myeloma ◽  
Multidrug Resistance ◽  
Cell Line ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Multiple Myeloma Cell

Molecular events underlying interleukin-6 independence in a subclone of the CMA-03 multiple myeloma cell line

2013 ◽  
Vol 53 (2) ◽  
pp. 154-167 ◽  
Author(s):  
Donata Verdelli ◽  
Lucia Nobili ◽  
Katia Todoerti ◽  
Laura Mosca ◽  
Sonia Fabris ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Interleukin 6 ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Multiple Myeloma Cell ◽  
Molecular Events

Zataria multiflora methanolic extract has antitumor properties on U266 multiple myeloma cell line

Gene Reports ◽  
2020 ◽  
Vol 20 ◽  
pp. 100655
Author(s):  
Hussein Anani ◽  
Iman Baluchi ◽  
Alireza Farsinejad ◽  
Ahmad Fatemi ◽  
Roohollah Mirzaee Khalilabadi
Keyword(s):  
Multiple Myeloma ◽  
Cell Line ◽  
Methanolic Extract ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Zataria Multiflora ◽  
Multiple Myeloma Cell ◽  
Antitumor Properties
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