Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion

Fitoterapia ◽  
2015 ◽  
Vol 102 ◽  
pp. 189-197 ◽  
Author(s):  
Wenping Wang ◽  
Qian Kang ◽  
Na Liu ◽  
Qing Zhang ◽  
Yewen Zhang ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Solid Dispersion ◽  
Ginkgo Biloba ◽  
Oral Bioavailability ◽  
Hot Melt Extrusion ◽  
Ginkgo Biloba Extract ◽  
Melt Extrusion ◽  
Enhanced Dissolution ◽  
Hot Melt

Enhanced dissolution rate and oral bioavailability of ginkgo biloba extract by preparing nanoparticles via emulsion solvent evaporation combined with freeze drying (ESE-FR)

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77346-77357 ◽  
Author(s):  
Lingling Wang ◽  
Xiuhua Zhao ◽  
Yuangang Zu ◽  
Weiwei Wu ◽  
Yuanyuan Li ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Ginkgo Biloba ◽  
Oral Bioavailability ◽  
Freeze Drying ◽  
Ginkgo Biloba Extract ◽  
Solvent Evaporation ◽  
Potential Value ◽  
Enhanced Dissolution

Dissolution rate and oral bioavailability of GBE nanoparticles were significantly improved by emulsion solvent evaporation combined with freeze drying (ESE-FR), implying that ESE-FR has great potential value in the preparation of oral GBE drugs.

scholarly journals Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Angelica gigas Nakai

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Yunyao Jiang ◽  
Jingpei Piao ◽  
Nan Liu ◽  
Jincai Hou ◽  
Jianxun Liu ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Hot Melt Extrusion ◽  
Total Phenolic ◽  
No Production ◽  
Melt Extrusion ◽  
Angelica Gigas ◽  
Kv1.3 Channel ◽  
Ultrafine Grinding ◽  
Anti Inflammatory ◽  
Hot Melt

Angelica gigas Nakai (AGN) was first processed by ultrafine grinding technology and hot-melt extrusion (HME). The potential antioxidant and anti-inflammatory activities of AGN with a different process were compared, and the effect on the human Kv1.3 potassium channel was detected. The process of ultrafine powderization on AGN significantly increased the total phenolic and flavonoid contents, antioxidant activity, and DNA damage protective effect. On the contrary, AGN solid dispersion (AGN-SD) based on Soluplus® showed the highest inhibitory effect on NO production and the human Kv1.3 channel. In addition, AGN-SD inhibited the production of prostaglandin E2 and intracellular reactive oxygen species and the mRNA expression of inducible nitric oxide synthase, cyclooxygenase-2, interleukin 1β, and interleukin 6. Taken together, these results suggest that ultrafine powderization and solid dispersion formation via HME can significantly improve the biological activities of AGN. The results also suggested that ultrafine powderization and HME may be developed and applied in the pharmaceutical industry.

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