Effects of dietary broccoli fibre and corn oil on serum lipids, faecal bile acid excretion and hepatic gene expression in rats

2012 ◽  
Vol 131 (4) ◽  
pp. 1272-1278 ◽  
Author(s):  
Tafadzwa Mandimika ◽  
Gunaranjan Paturi ◽  
Cloe Erika De Guzman ◽  
Christine A. Butts ◽  
Katia Nones ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bile Acid ◽  
Serum Lipids ◽  
Corn Oil ◽  
Hepatic Gene Expression ◽  
Acid Excretion ◽  
Bile Acid Excretion

scholarly journals Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits

1993 ◽  
Vol 34 (10) ◽  
pp. 1675-1685
Author(s):  
JA Poorman ◽  
RA Buck ◽  
SA Smith ◽  
ML Overturf ◽  
DS Loose-Mitchell
Keyword(s):  
Bile Acid ◽  
Acid Excretion ◽  
Bile Acid Excretion

Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice

Nutrition ◽  
2010 ◽  
Vol 26 (3) ◽  
pp. 321-330 ◽  
Author(s):  
Jungae Jeun ◽  
Sukyung Kim ◽  
Sung-Yun Cho ◽  
Hee-jin Jun ◽  
Hyun-Jin Park ◽  
...  
Keyword(s):  
Bile Acid ◽  
Lactobacillus Plantarum ◽  
Acid Excretion ◽  
Bile Acid Excretion

Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water

1999 ◽  
Vol 11 (4) ◽  
pp. 273-276 ◽  
Author(s):  
A. Capurso ◽  
V. Solfrizzi ◽  
F. Panza ◽  
F. Mastroianni ◽  
F. Torres ◽  
...  
Keyword(s):  
Bile Acid ◽  
Serum Cholesterol ◽  
Mineral Water ◽  
Acid Excretion ◽  
Bile Acid Excretion

scholarly journals Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits.

1990 ◽  
Vol 31 (11) ◽  
pp. 2019-2027
Author(s):  
ML Overturf ◽  
SA Smith ◽  
AM Gotto ◽  
JD Morrisett ◽  
T Tewson ◽  
...  
Keyword(s):  
Bile Acid ◽  
Dietary Cholesterol ◽  
Cholesterol Absorption ◽  
Acid Excretion ◽  
Bile Acid Excretion

scholarly journals Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7α-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice

1999 ◽  
Vol 81 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Vinti Goel ◽  
Sukhinder K. Cheema ◽  
Luis B. Agellon ◽  
Buncha Ooraikul ◽  
Tapan K. Basu
Keyword(s):  
Bile Acid ◽  
Plasma Cholesterol ◽  
Cholesterol Acyltransferase ◽  
Acid Excretion ◽  
Hydroxylase Activity ◽  
Bile Acid Pool ◽  
Bile Acid Excretion ◽  
Cholesteryl Ester Content ◽  
Rheum Rhaponticum ◽  
Increased Activity

Both experimental and clinical studies have indicated that a novel source of dietary fibre, produced from rhubarb (Rheum rhaponticum) stalks, is potentially hypolipidaemic. The present study, using C57BL/6J mice, was undertaken to examine if this fibre source affects cholesterol degradation. Mice were maintained on semi-purified diets containing 50 g rhubarb fibre or cellulose/kg with or without 5 g cholesterol/kg for 4 weeks. In cholesterol-supplemented mice, rhubarb fibre caused significant lowering of plasma cholesterol (-13 %) and the hepatic concentrations of total cholesterol (-34 %) and cholesteryl esters (-34 %). In parallel to the reduction of hepatic cholesteryl ester content, animals fed on rhubarb fibre had significantly lower activity of acyl CoA: cholesterol acyltransferase (EC 2.3.1.26) than the mice maintained on a diet containing cellulose and cholesterol. Rhubarb-fibre feeding accelerated the faecal bile-acid loss and diminished the gall-bladder bile-acid pool in both the normal and the cholesterol-fed mice. The increase in the bile-acid excretion was positively correlated with an increased activity as well as mRNA abundance of cholesterol 7α-hydroxylase (EC 1.14.13.17). The increased excretion of bile acids and induction of cholesterol 7α-hydroxylase activity may account for the hypocholesterolaemic effect of rhubarb fibre.

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