Drying kinetics and particle formation of potato powder during spray drying probed by microrheology and single droplet drying

2019 ◽  
Vol 116 ◽  
pp. 483-491 ◽  
Author(s):  
Yaoyao Tan ◽  
Yue Zhao ◽  
Honghai Hu ◽  
Nan Fu ◽  
Chunjiang Zhang ◽  
...  
Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 625 ◽  
Author(s):  
Eline Boel ◽  
Robin Koekoekx ◽  
Sien Dedroog ◽  
Iurii Babkin ◽  
Maria Rosaria Vetrano ◽  
...  

Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and acceleration of process development.


2014 ◽  
Vol 32 (6) ◽  
pp. 1993-2002 ◽  
Author(s):  
Jari Pekka Pajander ◽  
Sanni Matero ◽  
Jakob Sloth ◽  
Feng Wan ◽  
Jukka Rantanen ◽  
...  

2018 ◽  
Vol 36 (15) ◽  
pp. 1802-1813 ◽  
Author(s):  
Amanda Lum ◽  
Shahnaz Mansouri ◽  
Karen Hapgood ◽  
Meng Wai Woo

2010 ◽  
Vol 28 (2) ◽  
pp. 278-293 ◽  
Author(s):  
M. Mezhericher ◽  
A. Levy ◽  
I. Borde

2017 ◽  
Vol 35 (13) ◽  
pp. 1571-1583 ◽  
Author(s):  
T. T. H. Tran ◽  
M. Jaskulski ◽  
E. Tsotsas

Author(s):  
Belal Al Zaitone

Cellulose nanofibers (CNF) is used in various pharmaceutical applications due to its unique characteristics i.e., biodegradability, mechanical and biological properties. CNF is often produced by spray drying process, knowledge of the drying kinetics in terms of mass and heat transfer on the scale of single droplet is important for process development and model validation. Acoustic levitator was used to study drying process of CNF suspension at different air temperatures and initial CNF concentrations. The unique property of acoustic levitation to hold single droplet contactless in the air, enables to study particle morphology during drying process, calculate evaporation rate and estimate particle porosity. Results show that packed particles result at lower initial concentration and temperature has a moderate influence on mean porosity of CNF dried particles. Keywords: acoustic levitation; droplet; drying kinetics; Cellulose Nanofibers 


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