Co-encapsulation of coenzyme Q10 and vitamin E: A study of microcapsule formation and its relation to structure and functionalities using single droplet drying and micro-fluidic-jet spray drying

2019 ◽  
Vol 247 ◽  
pp. 45-55 ◽  
Author(s):  
Elaine Huang ◽  
Siew Young Quek ◽  
Nan Fu ◽  
Winston Duo Wu ◽  
Xiao Dong Chen
Keyword(s):  
Vitamin E ◽  
Spray Drying ◽  
Coenzyme Q10 ◽  
Single Droplet ◽  
Droplet Drying

Raman Mapping of Mannitol/Lysozyme Particles Produced Via Spray Drying and Single Droplet Drying

2014 ◽  
Vol 32 (6) ◽  
pp. 1993-2002 ◽  
Author(s):  
Jari Pekka Pajander ◽  
Sanni Matero ◽  
Jakob Sloth ◽  
Feng Wan ◽  
Jukka Rantanen ◽  
...  
Keyword(s):  
Spray Drying ◽  
Raman Mapping ◽  
Single Droplet ◽  
Droplet Drying

Drying kinetics and particle formation of potato powder during spray drying probed by microrheology and single droplet drying

2019 ◽  
Vol 116 ◽  
pp. 483-491 ◽  
Author(s):  
Yaoyao Tan ◽  
Yue Zhao ◽  
Honghai Hu ◽  
Nan Fu ◽  
Chunjiang Zhang ◽  
...  
Keyword(s):  
Spray Drying ◽  
Particle Formation ◽  
Drying Kinetics ◽  
Single Droplet ◽  
Potato Powder ◽  
Droplet Drying

Reduction of a model for single droplet drying and application to CFD of skim milk spray drying

2017 ◽  
Vol 35 (13) ◽  
pp. 1571-1583 ◽  
Author(s):  
T. T. H. Tran ◽  
M. Jaskulski ◽  
E. Tsotsas
Keyword(s):  
Spray Drying ◽  
Skim Milk ◽  
Single Droplet ◽  
Droplet Drying

scholarly journals Single droplet drying for optimal spray drying of enzymes and probiotics

2012 ◽  
Vol 27 (2) ◽  
pp. 73-82 ◽  
Author(s):  
Maarten A.I. Schutyser ◽  
Jimmy Perdana ◽  
Remko M. Boom
Keyword(s):  
Spray Drying ◽  
Single Droplet ◽  
Droplet Drying

scholarly journals Unraveling Particle Formation: From Single Droplet Drying to Spray Drying and Electrospraying

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 625 ◽  
Author(s):  
Eline Boel ◽  
Robin Koekoekx ◽  
Sien Dedroog ◽  
Iurii Babkin ◽  
Maria Rosaria Vetrano ◽  
...  
Keyword(s):  
Spray Drying ◽  
Formation Process ◽  
Process Development ◽  
Particle Morphology ◽  
Cost Effective ◽  
Particle Formation ◽  
Particle Engineering ◽  
Single Droplet ◽  
Comprehensive Overview ◽  
Droplet Drying

Spray drying and electrospraying are well-established drying processes that already have proven their value in the pharmaceutical field. However, there is currently still a lack of knowledge on the fundamentals of the particle formation process, thereby hampering fast and cost-effective particle engineering. To get a better understanding of how functional particles are formed with respect to process and formulation parameters, it is indispensable to offer a comprehensive overview of critical aspects of the droplet drying and particle formation process. This review therefore closely relates single droplet drying to pharmaceutical applications. Although excellent reviews exist of the different aspects, there is, to the best of our knowledge, no single review that describes all steps that one should consider when trying to engineer a certain type of particle morphology. The findings presented in this article have strengthened the predictive value of single droplet drying for pharmaceutical drying applications like spray drying and electrospraying. Continuous follow-up of the particle formation process in single droplet drying experiments hence allows optimization of manufacturing processes and particle engineering approaches and acceleration of process development.

scholarly journals Gaining insight on spray drying behavior of foods via single droplet drying analyses

2018 ◽  
Vol 37 (5) ◽  
pp. 525-534 ◽  
Author(s):  
Maarten A. I. Schutyser ◽  
Eline M. Both ◽  
Isabel Siemons ◽  
Evelien M. J. Vaessen ◽  
Lu Zhang
Keyword(s):  
Spray Drying ◽  
Single Droplet ◽  
Drying Behavior ◽  
Droplet Drying ◽  
Gaining Insight

scholarly journals Silymarin in Combination with Vitamin C, Vitamin E, Coenzyme Q10 and Selenomethionine to Improve Liver Enzymes and Blood Lipid Profile in NAFLD Patients

Medicina ◽  
2020 ◽  
Vol 56 (10) ◽  
pp. 544
Author(s):  
Annalisa Curcio ◽  
Adriana Romano ◽  
Simona Cuozzo ◽  
Antonio Di Nicola ◽  
Orazio Grassi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Liver Function ◽  
Vitamin C ◽  
Coenzyme Q10 ◽  
Liver Enzymes ◽  
Lifestyle Modification ◽  
Tolerability Profile ◽  
Blood Profile ◽  
Alcoholic Fatty Liver ◽  
Glutamyl Transferase

Background and Objectives: Non-Alcoholic Fatty Liver Disease (NAFLD) is an emerging cause of hepatopathy that is showing an increasing trend and where the recommendations of lifestyle modification are often not sufficient. The aim of this study is to evaluate the efficacy and tolerability profile of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®) by analyzing liver enzymes, along with the lipidic profile, as markers of liver function, and ultrasound results in NAFLD patients. Materials and Methods: This study enrolled 81 patients with mild to severe NAFLD, divided into two groups: Group A (N = 41) received two capsules a day of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®), and Group B (N = 40) received only recommendations for lifestyle modification including hypocaloric diet, physical exercise and encouragement for weight loss. Patients have been evaluated at three timepoints: baseline (T0), after 45 days of treatment (T1) and after 90 days of treatment (T2), by collecting blood parameters of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT) and the lipid blood profile. Ultrasonographic results have been analyzed at T0 and T2, along with the tolerability profile and side effects, registered at time T2. Results: The administration of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®) was effective since it showed a significant reduction of the evaluated parameters of ALT, AST, ALP and GGT, a significant improvement of lipid parameters, evaluated as markers of liver function, and improvements of ultrasonographic results. The use of this formulation at the dosage of two capsules a day has been well tolerated and no adverse events have been reported during study period of three months. Conclusions: The administration of the association of silymarin, vitamin C, vitamin E, coenzyme Q10 and selenomethionine (Medronys epato®) was effective and well tolerated in the improvement of hepatic function of NAFLD patients.

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