scholarly journals Signaling through the vascular endothelial growth factor receptor VEGFR-2 protects hippocampal neurons from mitochondrial dysfunction and oxidative stress

2013 ◽  
Vol 63 ◽  
pp. 421-431 ◽  
Author(s):  
Tianfeng Hao ◽  
Patricia Rockwell
Keyword(s):  
Oxidative Stress ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Mitochondrial Dysfunction ◽  
Hippocampal Neurons ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor ◽  
And Oxidative Stress

Hypertension During Vascular Endothelial Growth Factor Inhibition: Focus on Nitric Oxide, Endothelin-1, and Oxidative Stress

2014 ◽  
Vol 20 (1) ◽  
pp. 135-145 ◽  
Author(s):  
Stephanie Lankhorst ◽  
Mariëtte H.W. Kappers ◽  
Joep H.M. van Esch ◽  
A.H. Jan Danser ◽  
Anton H. van den Meiracker
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Endothelin 1 ◽  
Endothelial Growth Factor ◽  
And Oxidative Stress

Fortgeschrittenes medulläres Schilddrüsenkarzinom: Vandetanib verbessert das progressionsfreie Überleben

2012 ◽  
Vol 03 (02) ◽  
pp. 93-92
Author(s):  
Alexander Kretzschmar
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Phase Iii ◽  
Vascular Endothelial ◽  
Medulläres Schilddrüsenkarzinom ◽  
Epidermal Growth ◽  
Endothelial Growth Factor

Vandetanib ist ein oraler Hemmer des RET-Kinase-, VEGF (Vascular Endothelial Growth Factor Receptor)- und EGFR (Epidermal Growth Factor Receptor)-Signalwegs. In einer zulassungsrelevanten, randomisierten, doppelblinden, placebokontrollierten Phase- III-Studie verlängerte der Tyrosinkinasehemmer das progressionsfreie Überleben (PFS) signifikant länger als Placebo.

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