Thiol antioxidants sensitize malabaricone C induced cancer cell death via reprogramming redox sensitive p53 and NF-κB proteins in vitro and in vivo

2020 ◽  
Vol 148 ◽  
pp. 182-199
Author(s):  
Mrityunjay Tyagi ◽  
Ajay Kumar Bauri ◽  
Subrata Chattopadhyay ◽  
Birija Sankar Patro
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Cancer Cell Death

scholarly journals Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms

2015 ◽  
Vol 26 (6) ◽  
pp. 1044-1057 ◽  
Author(s):  
Chen Wei ◽  
Ma Lin ◽  
Bian Jinjun ◽  
Feng Su ◽  
Cao Dan ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Protein Level ◽  
Cell Apoptosis ◽  
General Control ◽  
Screening Assay ◽  
Cancer Cell Apoptosis ◽  
Cancer Cell Death

General control nonderepressible kinase 2 (GCN2) is a promising target for cancer therapy. However, the role of GCN2 in cancer cell survival or death is elusive; further, small molecules targeting GCN2 signaling are not available. By using a GCN2 level-based drug screening assay, we found that GCN2 protein level critically determined the sensitivity of the cancer cells toward Na+,K+-ATPase ligand–induced apoptosis both in vitro and in vivo, and this effect was largely dependent on C/EBP homologous protein (CHOP) induction. Further analysis revealed that GCN2 is a short-lived protein. In A549 lung carcinoma cells, cellular β-arrestin1/2 associated with GCN2 and maintained the GCN2 protein level at a low level by recruiting the E3 ligase NEDD4L and facilitating consequent proteasomal degradation. However, Na+,K+-ATPase ligand treatment triggered the phosphorylation of GCN2 at threonine 899, which increased the GCN2 protein level by disrupting the formation of GCN2–β-arrestin–NEDD4L ternary complex. The enhanced GCN2 level, in turn, aggravated Na+,K+-ATPase ligand–induced cancer cell apoptosis. Our findings reveal that GCN2 can exert its proapoptotic function in cancer cell death by posttranslational mechanisms. Moreover, Na+,K+-ATPase ligands emerge as the first identified small-molecule drugs that can trigger cancer cell death by modulating GCN2 signaling.

pH-Triggered burst intracellular release from hollow microspheres to induce autophagic cancer cell death

2015 ◽  
Vol 3 (48) ◽  
pp. 9383-9396 ◽  
Author(s):  
Xin Liang ◽  
Ying Yang ◽  
Lijun Wang ◽  
Xianbing Zhu ◽  
Xiaowei Zeng ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cell ◽  
Hollow Microspheres ◽  
Cancer Cell Death ◽  
Intracellular Release

Rapamycin–NaHCO3-loaded HMs combined CQ–NaHCO3-loaded HMs could efficiently induce cancer cell death through apoptosis with autophagosome both in vitro and in vivo.

scholarly journals Proanthocyanidin Polymer-Rich Fraction of Stryphnodendron adstringens Promotes in Vitro and in Vivo Cancer Cell Death via Oxidative Stress

2018 ◽  
Vol 9 ◽  
Author(s):  
Vanessa Kaplum ◽  
Anelise C. Ramos ◽  
Marcia E. L. Consolaro ◽  
Maria A. Fernandez ◽  
Tânia Ueda-Nakamura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Cancer Cell ◽  
Cancer Cell Death

scholarly journals Smac peptide potentiates TRAIL- or paclitaxel-mediated ovarian cancer cell death in vitro and in vivo

2012 ◽  
Vol 29 (2) ◽  
pp. 515-522 ◽  
Author(s):  
HONG LUAN MAO ◽  
YINGXIN PANG ◽  
XIAOLEI ZHANG ◽  
FANG YANG ◽  
JINGFANG ZHENG ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Death

A water-soluble analog of triptolide induces ovarian cancer cell death in vitro and in vivo

2013 ◽  
Vol 130 (1) ◽  
pp. e130
Author(s):  
C. Rivard Hunt ◽  
M. Geller ◽  
C. Evans ◽  
R. Vogel ◽  
S. Ramakrishnan ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Water Soluble ◽  
Cancer Cell Death

scholarly journals Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo

PLoS ONE ◽  
2009 ◽  
Vol 4 (7) ◽  
pp. e6278 ◽  
Author(s):  
Beatrice Cousin ◽  
Emmanuel Ravet ◽  
Sandrine Poglio ◽  
Fabienne De Toni ◽  
Mélanie Bertuzzi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Adipose Tissue ◽  
Cancer Cell ◽  
Stromal Cells ◽  
Pancreatic Cancer Cell ◽  
Human Adipose Tissue ◽  
Cancer Cell Death
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