Who Are Protected by the Fundamental Guarantees under International Humanitarian Law? Part 2: Breaking with the Control Requirement in Light of the icc Case Law

International humanitarian law provides for fundamental guarantees, the content of which is similar irrespective of the nature of the armed conflict and which apply to individuals even if they do not fall into the categories of specifically protected persons under the Geneva Conventions. Those guarantees, all of which derive from the general requirement of human treatment, include prohibitions of specific conduct against persons, such as murder, cruel treatment, torture, sexual violence, or against property, such as pillaging. However, it is traditionally held that the entitlement to those guarantees depends upon two requirements: the ‘status requirement’, which basically means that the concerned persons must not or no longer take a direct part in hostilities, and the ‘control requirement’, which basically means that the concerned persons or properties must be under the control of a party to the armed conflict. This study argues in favour of breaking with these two requirements in light of the existing icc case law. That study is divided into two parts, with each part devoted to one requirement and made the object of a specific paper. The two papers follow the same structure. They start with general observations on the requirement concerned, examine the relevant icc case law and put forward several arguments in favour of an extensive approach to the personal scope of the fundamental guarantees. The first paper, which was published in the previous issue of this journal, dealt with the status requirement. It especially delved into the icc decisions in the Ntaganda case with respect to the issue of protection against intra-party violence. It advocated the applicability of the fundamental guarantees in such a context by rejecting the requirement of a legal status, on the basis of several arguments. Those arguments relied on ihl provisions protecting specific persons as well as on the potential for humanizing ihl on the matter and also on the approach making the status requirement relevant only when the fundamental guarantees apply in the conduct of hostilities. The second paper, which is published here, deals with the control requirement. It examines several icc cases in detail, including the Katanga and Ntaganda cases, in relation to the issue of the applicability of the fundamental guarantees in the conduct of hostilities. It is argued that the entitlement to those guarantees is not dependent upon any general control requirement, and that, as a result, some of these guarantees may apply in the conduct of hostilities. This concerns mainly those guarantees whose application or constitutive elements do not imply any physical control over the concerned persons or properties.

Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis

Amino acid availability is sensed by various signaling molecules, including general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). However, it is unclear how these sensors are associated with cancer cell survival under low amino acid availability. In the present study, we investigated AKT activation in non-small cell lung cancer (NSCLC) cells deprived of each one of 20 amino acids. Among the 20 amino acids, deprivation of glutamine, arginine, methionine, and lysine induced AKT activation. AKT activation was induced by GCN2/ATF4/REDD1 axis-mediated mTORC2 activation under amino acid deprivation. In CRISPR-Cas9-mediated REDD1-knockout cells, AKT activation was not induced by amino acid deprivation, indicating that REDD1 plays a major role in AKT activation under amino acid deprivation. Knockout of REDD1 sensitized cells cultured under glutamine deprivation conditions to radiotherapy. Taken together, GCN2/ATF4/REDD1 axis induced by amino acid deprivation promotes cell survival signal, which might be a potential target for cancer therapy.

Implications of soil nitrogen enhancement on the yield performance of soybean (Glycine max) in cadmium-polluted soil.

The growth, development and yield of important crop plants like soybean (Glycine max) are constantly under threat by continuous inputs of cadmium in the biosphere as a result of various industrial activities. This study investigated the level to which, addition of nitrogen fertilization can enhance plant survival, growth and yield development in a cadmium-polluted. Three accessions of Glycine max (TGm1, TGm2 and TGm3) were sown in a 12 mg/kg-cadmium polluted, which was thereafter amended with urea (FU), ammonia (FA), and ammonium nitrate (FN) singly and in combinations of equal proportions. A non-fertilized Cd-polluted soil and a general control constituted the negative and positive controls. Results showed that although N application did not enhance yield dispositions of soybean in Cd polluted soil, significant impact on vegetative development was noteworthy. Compared to yield of control plants, cadmium pollution imposed a 26.1% reduction in per plant yield in TGm-1, compared 1.71% in TGm-3. Generally, addition of nitrogenous fertilizer further suppressed crop yield by as much as 80% in plants sown in cadmium-polluted soil. However, application of ammonia fertilizer to TGm-2 improved its yield performances in the cadmium-polluted soil.

Implications of soil nitrogen enhancement on the yield performance of soybean (Glycine max) in cadmium-polluted soil

The growth, development and yield of important crop plants like soybean (Glycine max) are constantly under threat by continuous inputs of cadmium in the biosphere as a result of various industrial activities. This study investigated the level to which, addition of nitrogen fertilization can enhance plant survival, growth and yield development in a cadmium-polluted. Three accessions of Glycine max (TGm1, TGm2 and TGm3) were sown in a 12 mg/kg-cadmium polluted, which was thereafter amended with urea (FU), ammonia (FA), and ammonium nitrate (FN) singly and in combinations of equal proportions. A non-fertilized Cd-polluted soil and a general control constituted the negative and positive controls. Results showed that although N application did not enhance yield dispositions of soybean in Cd polluted soil, significant impact on vegetative development was noteworthy. Compared to yield of control plants, cadmium pollution imposed a 26.1 % reduction in per plant yield in TGm1, compared 1.71 % in TGm3. Generally, addition of nitrogenous fertilizer further suppressed crop yield by as much as 80 % in plants sown in cadmium-polluted soil. However, application of ammonia fertilizer to TGm2 improved its yield performances in the cadmium-polluted soil

Who Are Protected by the Fundamental Guarantees under International Humanitarian Law? Part 1: Breaking with the Status Requirement in Light of the icc Case Law

International humanitarian law provides for fundamental guarantees, the content of which is similar irrespective of the nature of the armed conflict, and which are applicable to individuals even if they do not fall into the categories of specifically protected persons under the 1949 Geneva Conventions. Those guarantees, all of which derive from the general requirement of human treatment, include prohibitions of specific types of conduct against persons, such as murder, cruel treatment, torture and sexual violence, or against property, such as pillaging. However, it is traditionally held that entitlement to those guarantees depends upon two requirements: the ‘status requirement’, which basically means that the concerned persons must not or must no longer take a direct part in hostilities, and the ‘control requirement’, which basically means that the concerned persons or properties must be under the control of a party to the armed conflict. This study argues in favour of breaking with these two requirements, in light of the existing ICC case law. The study is divided into two parts, with each part devoted to one requirement and made the object of a specific paper. The two papers follow the same structure. They start with general observations on the requirement concerned, examine the relevant ICC case law and put forward several arguments in favour of an extensive approach to the personal scope of the fundamental guarantees. The first paper, which is published in this issue, deals with the status requirement. It especially delves into the ICC decisions in the Ntaganda case with respect to the issue of protection against intra-party violence. It advocates for the applicability of the fundamental guarantees in such a context by rejecting the requirement of a legal status, on the basis of several arguments. Those arguments rely on IHL provisions protecting specific persons, on the potential for humanizing IHL on the matter and on the approach making the status requirement relevant only when the fundamental guarantees apply in the conduct of hostilities. The second paper, which will be published in a coming issue, deals with the control requirement. It examines several ICC cases in detail, including the Katanga and Ntaganda cases, in relation to the issue of the applicability of the fundamental guarantees in the conduct of hostilities. It is argued that the entitlement to those guarantees is not dependent upon any general control requirement, and that, as a result, some of these guarantees (mainly those whose application or constitutive elements do not imply any physical control over the concerned persons or properties) may apply in the conduct of hostilities.

Application Effect of Comprehensive Nursing Intervention Model in Nursing of Children with Epilepsy

At present, the epilepsy disease of children in the growing groups of children and adolescents in my country is a very common mental disease, and it is very important to strengthen the early comprehensive treatment care and intervention therapy for children with epilepsy. The purpose of this study is to deeply explore the specific application effect of this comprehensive clinical nursing intervention model in the clinical nursing treatment of early childhood epilepsy patients. In this research, 80 cases of children with new-type pediatric epilepsy who received rehabilitation treatment in our hospital from August 2018 to December 2019 were selected as the observation objects of the clinical study.The children in the control group received short-term routine rehabilitation care, while the observation group adopted short-term comprehensive rehabilitation care and interventional treatment in parallel with long-term clinical rehabilitation care. The results of the research analysis show that the observation group’s hospitalization satisfaction of children with acute epilepsy is 96.73%, which is significantly higher than that of the general control group, 85.32%. The compliance rate of hospitalized children with acute epilepsy in the observation group was 95.22%, which was significantly higher than that of the general control group, 83.48%. The difference was obviously statistically significant (p<0.05). It can be seen from this that the treatment of children with epilepsy early adopting comprehensive nursing intervention mode can effectively improve the effect of epilepsy treatment.

Social narcissism – how society pushes us to overestimate our capacities, leaving many behind

The following introduces the concept of overlife, not claiming that it is an entirely new idea, however suggesting that it is a suitable term to bring different problems of contemporary societal development together. Broadly speaking, overload is defined as simultaneously condensing patterns of life and the actual living, i.e. intensifying living by establishing patterns of multitasking; however, doing so occurs for the price of a shallowed concept of life by a differentiated system of standardization. Simplification of cognition and education, not least in the context of digitization, are important factors: The apparently increasing control, everybody experiences, goes hand-in-hand with increasing difficulties of understanding – and enjoying – the complexity with which we are confronted. Still, although this seems to be a secular process concerning humanity and humans in general, control and power remains in the hands of a few who, as individuals and corporations, design life and society. Paradoxically, the theoretically gained possibility to answer complex questions and develop long-term perspectives, turns, at least under capitalist conditions, into narcissistic idiosyncrasies, and wasting huge amounts of monies for the thrill of egos instead of strategically developing socio-economic strategies addressing major challenges as poverty, environmental threats, digitisation and new forms of stupidification