A comparative study on antioxidant potentials, inhibitory activities against key enzymes related to metabolic syndrome, and anti-inflammatory activity of leaf extract from different Momordica species

Populus deltoides, known as eastern cottonwood, has been commonly used as a medicinal plant. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory activity of P. deltoides leaf extract (PLE). PLE effectively inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, but not that of cyclooxygenase-2 (COX-2) and prostaglandin E2. Proinflammatory tumor necrosis factor alpha (TNF-α) levels were also reduced by the extract. PLE inhibited the phosphorylation of nuclear factor-kappa B (NF-κB) and inhibitor of Kappa Bα (IκBα), and blunted LPS-triggered enhanced nuclear translocation of NF-κB p65. In mitogen-activated protein kinase (MAPK) signaling, PLE effectively decreased the phosphorylation of p38 and c-Jun N-terminal protein kinase (JNK), but not of extracellular signal-regulated kinase 1/2 (ERK1/2). Taken together, these results suggest that anti-inflammatory activity of P. deltoides leaf extract might be driven by iNOS and NO inhibition mediated by modulation of the NF-κB and p38/JNK signaling pathways.

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Analgesic and Anti-Inflammatory Activity of Total Crude Leaf Extract of <i>Phytolacca dodecandra</i> in Wistar Albino Rats

Neuroscience &amp Medicine ◽

10.4236/nm.2019.103020 ◽

2019 ◽

Vol 10 (03) ◽

pp. 259-271

Author(s):

Loyce Nakalembe ◽

Josephine N. Kasolo ◽

Edward Nyatia ◽

Aloysius Lubega ◽

Godfrey S. Bbosa

Keyword(s):

Leaf Extract ◽

Inflammatory Activity ◽

Albino Rats ◽

Phytolacca Dodecandra ◽

Crude Leaf Extract ◽

Anti Inflammatory ◽

Wistar Albino Rats

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Analgesic and anti-inflammatory activity of methanolic fraction of total ethereal leaf extract of Annona senegalensis Pers. (Annonaceae)

African Journal of Pharmacy and Pharmacology ◽

10.5897/ajpp2017.4735 ◽

2017 ◽

Vol 11 (8) ◽

pp. 120-124 ◽

Cited By ~ 1

Author(s):

Sene Madièye ◽

S. Barboza Firmin ◽

Sarr Abdou ◽

Tchemy Outouen Dominique ◽

Wele Alassane ◽

...

Keyword(s):

Leaf Extract ◽

Inflammatory Activity ◽

Anti Inflammatory

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Anti-inflammatory activity of Markhamia tomentosa (Benth.) K. Schum. Ex Engl. ethanolic leaf extract

Journal of Ethnopharmacology ◽

10.1016/j.jep.2013.06.020 ◽

2013 ◽

Vol 149 (1) ◽

pp. 191-194 ◽

Cited By ~ 14

Author(s):

Abimbola Sowemimo ◽

Femi Samuel ◽

Muyiwa Samuel Fageyinbo

Keyword(s):

Leaf Extract ◽

Inflammatory Activity ◽

Anti Inflammatory ◽

Ethanolic Leaf Extract

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Comparative study of anti-inflammatory activity of some branded generic and generic non-steroidal anti-inflammatory drugs

Clinical Research and Regulatory Affairs ◽

10.3109/10601333.2010.551403 ◽

2011 ◽

Vol 28 (2) ◽

pp. 27-33

Author(s):

Vedavathi Thavva ◽

Vijaya Ratna Jayanti ◽

Joseph Weinberg

Keyword(s):

Comparative Study ◽

Inflammatory Activity ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders

Phytomedicine ◽

10.1016/j.phymed.2018.08.010 ◽

2019 ◽

Vol 55 ◽

pp. 58-69 ◽

Cited By ~ 9

Author(s):

Biswajit Bose ◽

Debabrata Tripathy ◽

Anupam Chatterjee ◽

Pramod Tandon ◽

Suman Kumaria

Keyword(s):

Secondary Metabolite ◽

Metabolite Profiling ◽

Cognitive Disorders ◽

Key Enzymes ◽

Nardostachys Jatamansi ◽

Inhibitory Activities ◽

Anti Inflammatory

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Acute treatment with Mangifera indica L. leaf extract attenuates liver inflammation in rats fed a cafeteria diet

Food & Function ◽

10.1039/c9fo00651f ◽

2019 ◽

Vol 10 (8) ◽

pp. 4861-4867 ◽

Cited By ~ 5

Author(s):

Renata Celi Lopes Toledo ◽

Larissa Froede Brito ◽

Mônica Maria Magalhães Caetano ◽

Vânia Mayumi Nakajima ◽

Bárbara Pereira da Silva ◽

...

Keyword(s):

Acute Treatment ◽

Leaf Extract ◽

Mangifera Indica ◽

Cafeteria Diet ◽

Inflammatory Activity ◽

Liver Inflammation ◽

Anti Inflammatory

This study investigates the acute anti-inflammatory activity of Mangifera indica L. leaf extract and mangiferin in the liver of rats fed a cafeteria diet.

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