Bright light therapy as an adjunctive treatment with risperidone in patients with delirium: a randomized, open, parallel group study

2012 ◽  
Vol 34 (5) ◽  
pp. 546-551 ◽  
Author(s):  
Jaewon Yang ◽  
Wonseok Choi ◽  
Young-Hoon Ko ◽  
Sook-Haeng Joe ◽  
Changsu Han ◽  
...  
Keyword(s):  
Bright Light ◽  
Light Therapy ◽  
Adjunctive Treatment ◽  
Bright Light Therapy ◽  
Parallel Group Study ◽  
Parallel Group ◽  
Open Parallel

Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial

2020 ◽  
pp. 1-10
Author(s):  
Joey WY Chan ◽  
SP Lam ◽  
Shirley X Li ◽  
Steven WH Chau ◽  
SY Chan ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Remission Rate ◽  
Controlled Trial ◽  
Bright Light ◽  
Light Therapy ◽  
Adjunctive Treatment ◽  
Rank Test ◽  
Proportional Hazard ◽  
Bright Light Therapy ◽  
Cox Proportional Hazard

Abstract Background Unipolar non-seasonal depressed patients with concomitant evening chronotype were associated with poor clinical outcomes and higher non-remission rate. This study aims to examine the efficacy of adjunctive bright light therapy with gradual timing advance in a randomized, assessor and prescriber-blinded controlled trial. Method Participants were randomly allocated to receive 5 weeks of either bright white light therapy (BLT) or dim red light (DRL) with the same advancement protocol. Participants were followed up till 5 months after treatment. Primary outcomes included (i) remission rate and (ii) the severity of depression. The analysis was conducted using Kaplan–Meier survival analysis, Cox proportional hazard analysis and linear mixed models. Results A total of 93 participants (46.4 ± 11.7 years old, 80% female) were randomized. The cumulative remission rate for the BLT and the DRL groups was 67.4% and 46.7%, respectively. Time to remission was shorter for the BLT group relative to the DRL group (log-rank test p = 0.024). Cox proportional hazard survival analysis showed that patients in the BLT group had a higher probability of achieving remission relative to patients in the DRL group [hazard ratio = 1.9 (95% CI = 1.1– 3.4), p = 0.026]. Further sensitivity analysis demonstrated greater improvement in 17-Hamilton Depression Score (group × time interaction, p = 0.04) in the BLT group for those who were adherent to light therapy. Conclusions The use of bright light therapy with gradual advance protocol is an effective adjunctive treatment resulting in quicker and a higher rate of remission of depression in patients with non-seasonal unipolar depression and evening-chronotype.

Use of bright light therapy for older adults with dementia

2020 ◽  
Vol 26 (4) ◽  
pp. 221-228
Author(s):  
Lisa L. Onega ◽  
Thomas W. Pierce
Keyword(s):  
Older Adults ◽  
Light Exposure ◽  
Bright Light ◽  
Light Therapy ◽  
Adjunctive Treatment ◽  
Evidence Based ◽  
Bright Light Therapy ◽  
The Past ◽  
Bright Light Exposure ◽  
Circadian Rhythm Disorders

SUMMARYBright light therapy is an accepted and commonly used treatment for seasonal affective and circadian rhythm disorders. In the past 20 years, researchers have examined the effectiveness of bright light therapy in improving depression and agitation in older adults with dementia. This article provides clinicians with a summary of the neurophysiology of bright light therapy, bright light research considerations, an evidence-based bright light protocol, problems related to bright light therapy, and clinical implications for bright light therapy in older adults with dementia. Bright light exposure is a safe, non-pharmacological treatment that is currently underutilised in this population. Clinicians may find bright light therapy beneficial as a primary or adjunctive treatment in reducing depression and agitation in older adults with dementia.

Morning bright light therapy: a helpful tool for reducing comorbid symptoms of affective and behavioral dysregulation in juvenile depressed inpatients? A pilot trial

2017 ◽  
Vol 45 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Sarah Bogen ◽  
Tanja Legenbauer ◽  
Stephanie Gest ◽  
Martin Holtmann
Keyword(s):  
Pilot Trial ◽  
Secondary Analysis ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Circadian Phase ◽  
Behavioral Dysregulation ◽  
Sleep Parameters ◽  
Circadian Effect ◽  
Dysregulation Profile

Abstract. Objective: In recent years, bright light therapy (BLT) has been used to treat depression and to stabilize circadian rhythms. In this study we evaluated whether it is also helpful for comorbid symptoms of affective and behavioral dysregulation in depressive inpatients. Method: This article reports a secondary analysis comparing two subgroups of depressive participants with comorbid affective and behavioral dysregulation, captured with the dysregulation-profile of the Strengths and Difficulties Questionnaire (SDQ-DP; n = 16 vs. n = 11). Participants were randomly allocated to active BLT (10,000 lux) or control BLT (approx. 100 lux), and received 45 minutes of BLT for 2 weeks. SDQ-DP scores, sleep parameters, and circadian preference were assessed at baseline, after the intervention, and 3 weeks later. Results: No direct effects on SDQ-DP scores were observed. Sleep improved in both conditions. Only in the active BLT condition was a circadian phase advance found. Correlation and regression analyses indicated an indirect, circadian effect for improved SDQ-DP scores. Conclusions: The data of this pilot trial should be considered preliminary and merely descriptive. Further research is warranted.


Bright light therapy for depression in Parkinson disease

Neurology ◽  
2019 ◽  
pp. 10.1212/WNL.0000000000007090 ◽  
Author(s):  
Sonja Rutten ◽  
Chris Vriend ◽  
Jan H. Smit ◽  
Henk W. Berendse ◽  
Eus J.W. van Someren ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy

scholarly journals Effects of Dynamic Bedroom Lighting On Measures of Sleep and Circadian Rest-Activity Rhythm in Inpatients With Major Depressive Disorder

2021 ◽  
Author(s):  
Canazei Markus ◽  
Weninger Johannes ◽  
Pohl Wilfried ◽  
Marksteiner Josef ◽  
Weiss Elisabeth
Keyword(s):  
Activity Rhythm ◽  
Severe Depression ◽  
Bright Light ◽  
Light Therapy ◽  
Psychiatric Ward ◽  
Lighting System ◽  
Bright Light Therapy ◽  
Effective Treatment Option ◽  
Major Depressive ◽  
Rest Activity

Abstract Bright light therapy is an effective treatment option for seasonal and non-seasonal affective disorders. However up to now, no study has investigated effects of dynamic bedroom lighting in hospitalized patients with major depression. A bedroom lighting system, which automatically delivered artificial dawn and dusk and blue-depleted nighttime lighting (DD-N lighting) was installed in a psychiatric ward. Patients with moderate to severe depression were randomly assigned to stay in bedrooms with the new lighting or standard lighting system. Patients wore wrist actimeters during the first two treatment weeks. Additionally, hospitalization duration and daily psychotropic medication were retrieved from patients’ medical charts. Data from thirty patients were analyzed. Patients under DD-N lighting generally woke up earlier (+20 minutes), slept longer (week 1: +11 min; week 2: +27 min) and showed higher sleep efficiency (+2.4%) and shorter periods of nighttime awakenings (-15 minutes). In the second treatment week, patients started sleep and the most active 10-hour period earlier (-33 min and -64 min, respectively). This pilot study gives first evidence that depressed patients’ sleep and circadian rest/activity system may benefit from adjunctive bedroom lighting when starting inpatient treatment.

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