Adjunctive bright light treatment with gradual advance in unipolar major depressive disorder with evening chronotype – A randomized controlled trial

2020 ◽  
pp. 1-10
Author(s):  
Joey WY Chan ◽  
SP Lam ◽  
Shirley X Li ◽  
Steven WH Chau ◽  
SY Chan ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Remission Rate ◽  
Controlled Trial ◽  
Bright Light ◽  
Light Therapy ◽  
Adjunctive Treatment ◽  
Rank Test ◽  
Proportional Hazard ◽  
Bright Light Therapy ◽  
Cox Proportional Hazard

Abstract Background Unipolar non-seasonal depressed patients with concomitant evening chronotype were associated with poor clinical outcomes and higher non-remission rate. This study aims to examine the efficacy of adjunctive bright light therapy with gradual timing advance in a randomized, assessor and prescriber-blinded controlled trial. Method Participants were randomly allocated to receive 5 weeks of either bright white light therapy (BLT) or dim red light (DRL) with the same advancement protocol. Participants were followed up till 5 months after treatment. Primary outcomes included (i) remission rate and (ii) the severity of depression. The analysis was conducted using Kaplan–Meier survival analysis, Cox proportional hazard analysis and linear mixed models. Results A total of 93 participants (46.4 ± 11.7 years old, 80% female) were randomized. The cumulative remission rate for the BLT and the DRL groups was 67.4% and 46.7%, respectively. Time to remission was shorter for the BLT group relative to the DRL group (log-rank test p = 0.024). Cox proportional hazard survival analysis showed that patients in the BLT group had a higher probability of achieving remission relative to patients in the DRL group [hazard ratio = 1.9 (95% CI = 1.1– 3.4), p = 0.026]. Further sensitivity analysis demonstrated greater improvement in 17-Hamilton Depression Score (group × time interaction, p = 0.04) in the BLT group for those who were adherent to light therapy. Conclusions The use of bright light therapy with gradual advance protocol is an effective adjunctive treatment resulting in quicker and a higher rate of remission of depression in patients with non-seasonal unipolar depression and evening-chronotype.

Use of bright light therapy for older adults with dementia

2020 ◽  
Vol 26 (4) ◽  
pp. 221-228
Author(s):  
Lisa L. Onega ◽  
Thomas W. Pierce
Keyword(s):  
Older Adults ◽  
Light Exposure ◽  
Bright Light ◽  
Light Therapy ◽  
Adjunctive Treatment ◽  
Evidence Based ◽  
Bright Light Therapy ◽  
The Past ◽  
Bright Light Exposure ◽  
Circadian Rhythm Disorders

SUMMARYBright light therapy is an accepted and commonly used treatment for seasonal affective and circadian rhythm disorders. In the past 20 years, researchers have examined the effectiveness of bright light therapy in improving depression and agitation in older adults with dementia. This article provides clinicians with a summary of the neurophysiology of bright light therapy, bright light research considerations, an evidence-based bright light protocol, problems related to bright light therapy, and clinical implications for bright light therapy in older adults with dementia. Bright light exposure is a safe, non-pharmacological treatment that is currently underutilised in this population. Clinicians may find bright light therapy beneficial as a primary or adjunctive treatment in reducing depression and agitation in older adults with dementia.

scholarly journals Effects of bright light therapy for depression during pregnancy: a randomised, double-blind controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. e038030
Author(s):  
Babette Bais ◽  
Astrid M Kamperman ◽  
Hilmar H Bijma ◽  
Witte JG Hoogendijk ◽  
Jan L Souman ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Pregnant Women ◽  
Rating Scale ◽  
Controlled Trial ◽  
Depression Scale ◽  
Bright Light ◽  
Light Therapy ◽  
Secondary Outcome ◽  
Bright Light Therapy ◽  
Double Blind

ObjectivesApproximately 11%–13% of pregnant women suffer from depression. Bright light therapy (BLT) is a promising treatment, combining direct availability, sufficient efficacy, low costs and high safety for both mother and child. Here, we examined the effects of BLT on depression during pregnancy.DesignRandomised, double-blind controlled trial.SettingPrimary and secondary care in The Netherlands, from November 2016 to March 2019.Participants67 pregnant women (12–32 weeks gestational age) with a DSM-5 diagnosis of depressive disorder (Diagnostic and Statistical Manual of Mental Disorders).InterventionsParticipants were randomly allocated to treatment with either BLT (9000 lux, 5000 K) or dim red light therapy (DRLT, 100 lux, 2700 K), which is considered placebo. For 6 weeks, both groups were treated daily at home for 30 min on awakening. Follow-up took place weekly during the intervention, after 6 weeks of therapy, 3 and 10 weeks after treatment and 2 months postpartum.Primary and secondary outcome measuresDepressive symptoms were measured primarily with the Structured Interview Guide for the Hamilton Depression Scale—Seasonal Affective Disorder. Secondary measures were the Hamilton Rating Scale for Depression and the Edinburgh Postnatal Depression Scale. Changes in rating scale scores of these questionnaires over time were analysed using generalised linear mixed models.ResultsMedian depression scores decreased by 40.6%–53.1% in the BLT group and by 50.9%–66.7% in the DRLT group. We found no statistically significant difference in symptom change scores between BLT and DRLT. Sensitivity and post-hoc analyses did not change our findings.ConclusionsDepressive symptoms of pregnant women with depression improved in both treatment arms. More research is necessary to determine whether these responses represent true treatment effects, non-specific treatment responses, placebo effects or a combination hereof.Trial registration numberNTR5476.

Bright light therapy as an adjunctive treatment with risperidone in patients with delirium: a randomized, open, parallel group study

2012 ◽  
Vol 34 (5) ◽  
pp. 546-551 ◽  
Author(s):  
Jaewon Yang ◽  
Wonseok Choi ◽  
Young-Hoon Ko ◽  
Sook-Haeng Joe ◽  
Changsu Han ◽  
...  
Keyword(s):  
Bright Light ◽  
Light Therapy ◽  
Adjunctive Treatment ◽  
Bright Light Therapy ◽  
Parallel Group Study ◽  
Parallel Group ◽  
Open Parallel

scholarly journals Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial

2018 ◽  
Vol 175 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Dorothy K. Sit ◽  
James McGowan ◽  
Christopher Wiltrout ◽  
Rasim Somer Diler ◽  
John (Jesse) Dills ◽  
...  
Keyword(s):  
Bipolar Depression ◽  
Controlled Trial ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Double Blind ◽  
Double Blind Placebo

Controlled trial of safety and efficacy of bright light therapy vs. negative air ions in patients with bipolar depression

2012 ◽  
Vol 196 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Deborah Rozenn Dauphinais ◽  
Joshua Zev Rosenthal ◽  
Michael Terman ◽  
Holly Marie DiFebo ◽  
Catherine Tuggle ◽  
...  
Keyword(s):  
Bipolar Depression ◽  
Controlled Trial ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Air Ions ◽  
Safety And Efficacy ◽  
Negative Air Ions

Treatment of depressive symptoms in patients with breast cancer: A randomized controlled trial comparing cognitive therapy and bright light therapy.

2018 ◽  
Vol 37 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Caroline Desautels ◽  
Josée Savard ◽  
Hans Ivers ◽  
Marie-Hélène Savard ◽  
Aude Caplette-Gingras
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Depressive Symptoms ◽  
Cognitive Therapy ◽  
Controlled Trial ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Randomized Controlled

Bright light therapy for agitation in dementia: a randomized controlled trial

2009 ◽  
Vol 21 (4) ◽  
pp. 711-721 ◽  
Author(s):  
Alistair Burns ◽  
Harry Allen ◽  
Barbara Tomenson ◽  
Debbie Duignan ◽  
Jane Byrne
Keyword(s):  
Randomized Controlled Trial ◽  
Drug Treatment ◽  
Controlled Trial ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Randomized Controlled ◽  
People With Dementia ◽  
Potential Alternative ◽  
Clinical Trials Registry

ABSTRACTBackground: Agitation is common in people with dementia, is distressing to patients and stressful to their carers. Drugs used to treat the condition have the potential to cause particularly severe side effects in older people with dementia and have been associated with an increased death rate. Alternatives to drug treatment for agitation should be sought. The study aimed to assess the effects of bright light therapy on agitation and sleep in people with dementia.Methods: A single center randomized controlled trial of bright light therapy versus standard light was carried out. The study was completed prior to the mandatory registration of randomized controls on the clinical trials registry database and, owing to delays in writing up, retrospective registration was not completed.Results: There was limited evidence of reduction in agitation in people on active treatment, sleep was improved and a suggestion of greater efficacy in the winter months.Conclusions: Bright light therapy is a potential alternative to drug treatment in people with dementia who are agitated.

Sign in / Sign up

Export Citation Format

Share Document