scholarly journals Beneficial effects of exercise on chemotherapy-induced peripheral neuropathy and sleep disturbance: A review of literature and proposed mechanisms

2022 ◽  
pp. 100927
Author(s):  
L. Brett Whalen ◽  
W. Zachary Wright ◽  
Priyanka Kundur ◽  
Siddhartha Angadi ◽  
Susan C. Modesitt
Keyword(s):  
Peripheral Neuropathy ◽  
Sleep Disturbance ◽  
Review Of Literature ◽  
Beneficial Effects

scholarly journals A systematic review of behavioural and exercise interventions for the prevention and management of chemotherapy-induced peripheral neuropathy symptoms

2021 ◽  
Author(s):  
Mary Anne Lagmay Tanay ◽  
Jo Armes ◽  
Rona Moss-Morris ◽  
Anne Marie Rafferty ◽  
Glenn Robert
Keyword(s):  
Peripheral Neuropathy ◽  
Health Management ◽  
Experimental Studies ◽  
Self Management ◽  
Cochrane Library ◽  
Pharmacological Interventions ◽  
Behavioural Interventions ◽  
Exercise Interventions ◽  
Beneficial Effects ◽  
Recommended Treatment

Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) can result in functional difficulties. Pharmacological interventions used to prevent CIPN either show low efficacy or lack evidence to support their use and to date, duloxetine remains the only recommended treatment for painful CIPN. Non-pharmacological interventions such as exercise and behavioural interventions for CIPN exist. Purpose The aims were to (1) identify and appraise evidence on existing behavioural and exercise interventions focussed on preventing or managing CIPN symptoms, (2) describe psychological mechanisms of action by which interventions influenced CIPN symptoms, (3) determine the underpinning conceptual models that describe how an intervention may create behaviour change, (4) identify treatment components of each intervention and contextual factors, (5) determine the nature and extent of patient and clinician involvement in developing existing interventions and (6) summarise the relative efficacy or effectiveness of interventions to lessen CIPN symptoms and to improve quality of life, balance and muscle strength. Methods A systematic search of Ovid Medline, Cochrane Library, EMBASE, PsycINFO, Health Management Information Consortium, Global Health and CINAHL was performed to identify articles published between January 2000 to May 2020, followed by OpenGrey search and hand-searching of relevant journals. Studies that explored behavioural and/or exercise interventions designed to prevent or improve symptoms of CIPN in adults who had received or were receiving neurotoxic chemotherapy for any type of cancer, irrespective of when delivered within the cancer pathway were included. Results Nineteen randomised controlled trials and quasi-experimental studies which explored behavioural (n=6) and exercise (n=13) interventions were included. Four studies were rated as methodologically strong, ten were moderate and five were weak. Ten exercise and two behavioural interventions, including those that improved CIPN knowledge and self-management resources and facilitated symptom self-reporting, led to reduced CIPN symptoms during and/or after chemotherapy treatment. Conclusions The extent of potential benefits from the interventions was difficult to judge, due to study limitations. Future interventions should incorporate a clear theoretical framework and involve patients and clinicians in the development process. Implications for Cancer Survivors Our findings show exercise interventions have beneficial effects on CIPN symptoms although higher quality research is warranted. Behavioural interventions that increase patient’s CIPN knowledge, improve self-management capacity and enable timely access to symptom management led to reduced CIPN symptoms.

scholarly journals Diabetic peripheral neuropathy: epidemiology, pathogenesis, clinic, diagnostics, treatment

2016 ◽  
Vol 24 (4) ◽  
pp. 139-151 ◽  
Author(s):  
A N Belova ◽  
M N Kudykin ◽  
G E Sheiko
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Peripheral Nerves ◽  
Pain Syndrome ◽  
Common Complication ◽  
Review Of Literature ◽  
Chronic Hyperglycemia ◽  
Progressive Degeneration ◽  
Pathophysiologic Mechanisms

The article contains the review of literature data dedicated to the most common complication associated with diabetes mellitus (DM) - the diabetic peripheral neuropathy (DPN). DPN is regarded as economic burden for any state and significantly influences the quality of patient’s life. DPN is characterized by progressive degeneration of peripheral nerves that leads to pain syndrome, movement disorders and loss of sensation. There is a set of theories of development of DPN, but the major etiological factor is the chronic hyperglycemia. The article describes pathophysiologic mechanisms of DPN development. It is noted that considering high variability of clinical pattern DPN has no unified classification. The article addresses issues related to diagnostics and criteria of establishing the diagnosis. Special attention of the article is dedicated to pathogenic and expected treatment methods.

Hereditary sensory and autosomal peripheral neuropathy-type IV: case series and review of literature

2015 ◽  
Vol 19 (2) ◽  
pp. 117-123 ◽  
Author(s):  
D. P. Ashwin ◽  
G. D. Chandan ◽  
Handa Kaur Jasleen ◽  
G. C. Rajkumar ◽  
K. B. Rudresh ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Case Series ◽  
Review Of Literature ◽  
Type Iv

Determining priority symptoms of women with recurrent ovarian cancers: A Gynecologic Oncology Group study.

2016 ◽  
Vol 34 (26_suppl) ◽  
pp. 101-101 ◽  
Author(s):  
Heidi AS Donovan ◽  
Lari B. Wenzel ◽  
Sandra Ward ◽  
Susan M. Sereika ◽  
Robert P. Edwards ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Sleep Disturbance ◽  
Symptom Severity ◽  
Gynecologic Oncology ◽  
Well Being ◽  
Recurrent Ovarian Cancer ◽  
Gynecologic Oncology Group ◽  
Peritoneal Cancer ◽  
Ovarian Cancers ◽  
Patient Reported

101 Background: The purpose of this study is to recommend a core set of priority symptoms to be assessed in research and clinical settings for women with recurrent ovarian cancers. Methods: We used baseline data of 497 women with recurrent ovarian, fallopian, or primary peritoneal cancer participating in a symptom management randomized clinical trial (GOG-0259) to identify a core index of patient-reported priority symptoms. We used the Symptom Representation Questionnaire to assess priority rankings of 28 symptoms based on four criteria: (1) symptom prevalence, (2) patient-reported symptom severity, (3) percentage of women identifying each symptom as one of top three symptoms “I would like to get better control over”, and (4) the association between symptom severity and functional wellbeing as measured by the Functional Assessment of Cancer Therapy - Ovarian. Final priority ranking included all symptoms that were ranked in the top 10 for any of the four criteria. Results: Of the original 28 symptoms, 19 were ranked in the top 10 for at least one criterion: fatigue, sleep disturbance, pain, anxiety, peripheral neuropathy, constipation, abdominal bloating, drowsiness, mood swings, memory problems, weight gain, nausea, sexual concerns, vomiting, hair loss, lymphedema, lack of appetite, shortness of breath, and depression. Fatigue, sleep disturbance, and pain were each ranked one of the top 10 symptoms for all four criteria. Anxiety, peripheral neuropathy, and constipation were each ranked in the top 10 for three of the 4 criteria. Conclusions: We propose a core index of 19 patient-reported symptoms to be systematically assessed among patients with recurrent ovarian cancer. These symptoms are common, severe, poorly managed, and/or interfere with survivors’ functioning and can be efficiently assessed in 1-2 minutes. Systematic assessment in clinical and research settings could advance understanding about the predictors and consequences of poorly managed symptoms and could lead to more proactive, personalized interventions to improve functional well-being in this at-risk patient population.

Early Commencement of Enteral Feeds in Gastroschisis: A Systematic Review of Literature

2017 ◽  
Vol 27 (06) ◽  
pp. 503-515 ◽  
Author(s):  
Madhuri Dama ◽  
Uday Rao ◽  
Ian Gollow ◽  
Max Bulsara ◽  
Shripada Rao
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Review Of Literature ◽  
Beneficial Effects ◽  
Duration Of Hospital Stay ◽  
Randomized Controlled ◽  
Related Information ◽  
Meta Regression ◽  
Meta Regression Analysis ◽  
The Relationship

Introduction There are no evidence-based strategies to improve feed tolerance in gastroschisis. Early commencement of enteral feeds (CEF) is known to improve feed tolerance in preterm infants. It is possible that infants with gastroschisis may also benefit from early CEF. Objective To conduct a systematic review to evaluate the relationship between time of CEF, and time to reach full enteral feeds (FEF), duration of parenteral nutrition (PN), and duration of hospital stay (HS). Methods PubMed, EMBASE, Cochrane CENTRAL, and relevant conference abstracts were searched in December 2015. Studies of any design reporting on time to CEF and one or more of the outcomes of interest were included. Meta-regression analysis was conducted to find the association between time to CEF and the outcomes of interest. Results There were no randomized controlled trials (RCTs) comparing early (≤7 days from birth) versus delayed (>7 days) CEF. Forty-two observational studies on gastroschisis (4,835 infants) where feed-related information was available were included. Meta-regression results indicated that each day delay in CEF was associated with a delay of an additional 1.4 days (95% confidence interval [CI]: 0.95, 1.85) to FEF, 2.05 days (95% CI: 1.50, 2.59) to the duration of PN, and 1.91 days (95% CI: 1.37, 2.45) to the duration of HS. Sensitivity analysis after excluding studies that provided information exclusively on complex gastroschisis continued to show beneficial effects of early CEF. Conclusion Early CEF may be associated with early attainment of FEF in gastroschisis. RCTs comparing early versus delayed CEF are needed urgently.

scholarly journals Protection of Trigonelline on Experimental Diabetic Peripheral Neuropathy

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ji-Yin Zhou ◽  
Shi-Wen Zhou
Keyword(s):  
Peripheral Neuropathy ◽  
Sciatic Nerve ◽  
Nerve Conduction ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Conduction Velocity ◽  
Diabetic Rats ◽  
Beneficial Effects ◽  
Mitogen Activated Protein ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

The mechanisms leading to diabetic peripheral neuropathy are complex and there is no effective drug to treat it. As an active component of several traditional Chinese medicines, trigonelline has beneficial effects on diabetes with hyperlipidemia. The protective effects and the mechanism of trigonelline on diabetic peripheral neuropathy were evaluated in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Rats were divided into four groups at the end of week 2: control, diabetes, diabetes + trigonelline (40 mg/kg), and diabetes + sitagliptin (4 mg/kg). After 48-week treatment, technologies of nerve conduction, cold and hot immersion test, transmission electron microscopy, real-time PCR, and Western blotting were applied. Serum glucose, serum insulin, insulin sensitivity index, lipid parameters, body weight, sciatic nerve conduction velocity, nociception, glucagon-like peptide-1 receptor mRNA and protein, total and phosphorylated p38 mitogen-activated protein kinases protein expression, malonaldehyde content, and superoxide dismutase activity were altered in diabetic rats, and were near control levels treated with trigonelline. Slight micropathological changes existed in sciatic nerve of trigonelline-treated diabetic rats. These findings suggest that trigonelline has beneficial effects for diabetic peripheral neuropathy through glucagon-like peptide-1 receptor/p38 mitogen-activated protein kinases signaling pathway, nerve conduction velocity, antioxidant enzyme activity, improving micropathological changes of sciatic nerve and decreasing lipid peroxidation.

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