424: BOS-Development: Comparing the Kinetics of Systemic Host Immune Response after Experimental Heterotopic and Orthotopic Tracheal Transplantations

2008 ◽  
Vol 27 (2) ◽  
pp. S213
Author(s):  
S. Schrepfer ◽  
T. Deuse ◽  
R.C. Robbins
Keyword(s):  
Immune Response ◽  
Host Immune Response ◽  
Kinetics Of

The kinetics of repeated low-level infections of Nippostrongylus brasiliensis in the laboratory rat

Parasitology ◽  
1971 ◽  
Vol 62 (3) ◽  
pp. 457-465 ◽  
Author(s):  
D. Conwil Jenkins ◽  
R. F. Phillipson
Keyword(s):  
Immune Response ◽  
Technical Assistance ◽  
Repeated Administration ◽  
Host Immune Response ◽  
Primary Immune Response ◽  
Nippostrongylus Brasiliensis ◽  
Low Level ◽  
Laboratory Rat ◽  
Repeated Infections ◽  
Kinetics Of

The kinetics of low-level repeated infections of Nippostrongylus brasiliensis in the laboratory rat were studied.The administration of five infective larvae each weekday to the rats produced an infection which was cumulative over 16 weeks and which did not produce an acute host immune response.The repeated administration of 50 larvae/weekday produced a primary immune response after 14 days. This caused partial worm expulsion and the suppression of egg output but the resistance of these rats to reinfection was not as pronounced as that seen in classical laboratory infections where heavier but less frequent larval exposures are used. The secondary worms that established in these rats did not elicit an acute host immune response even when the worm burden was as high as 756 worms.It is suggested that the kinetics of this type of infection more closely approximate those found under natural conditions than do those of a ‘classical’ laboratory infection.We wish to thank Misses G. Merchant, L. Cleaver and J. Cobb for able technical assistance, and Dr B. M. Ogilvie (National Institute for Medical Research, Mill Hill, London) for her helpful comments and discussions.

scholarly journals Exposure of Immunocompetent Adult Mice to Pneumocystis carinii f. sp. muris by Cohousing: Growth of P. carinii f. sp. muris and Host Immune Response

2003 ◽  
Vol 71 (4) ◽  
pp. 2065-2070 ◽  
Author(s):  
Chun Li An ◽  
Francis Gigliotti ◽  
Allen G. Harmsen
Keyword(s):  
Immune Response ◽  
Pneumocystis Carinii ◽  
Clinical Signs ◽  
Host Immune Response ◽  
Immunocompetent Adult ◽  
Adult Mice ◽  
Specific Immunoglobulin ◽  
Immunocompetent Mice ◽  
Kinetics Of ◽  
Microscopic Techniques

ABSTRACT There has been emerging evidence that immunocompetent hosts can harbor Pneumocystis in their lungs. The purpose of this study was to determine the kinetics of Pneumocystis carinii f. sp. muris infection in adult immunocompetent mice and the host immune response to the organisms. To accomplish this, we exposed adult immunocompetent mice to SCID mice infected with P. carinii f. sp. muris by cohousing. We found that P. carinii f. sp. muris was detectable in the lungs of cohoused immunocompetent mice by PCR by 3 weeks after the beginning of cohousing. At about 4 weeks of cohousing, P. carinii f. sp. muris was readily detectable in the lungs of mice by microscopic techniques. Also at this time, P. carinii f. sp. muris-specific immunoglobulin G was found in the sera of the mice, and CD62low CD4- and CD8-positve T cells accumulated in the lungs. Shortly after this immune response, the P. carinii f. sp. muris organisms were cleared from the lungs. Adult mice cohoused for only 1 week also contained P. carinii f. sp. muris cysts detectable by silver staining at 5 and 6 weeks after the beginning of cohousing. We also found that the P. carinii f. sp. muris organisms grew to greater numbers in the lungs of BALB/c mice than in those of C57BL6 mice. This indicates that immunocompetent hosts develop a mild infection with P. carinii f. sp. muris which resolves in 5 to 6 weeks when there is a detectable immune response to the organism. Once an acquired immune response was initiated, the P. carinii f. sp. muris organisms were quickly eliminated without clinical signs of disease.

Kinetics of systemic host immune response after experimental heterotopic and orthotopic tracheal transplantations

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
T Deuse ◽  
D Weill ◽  
H Reichenspurner ◽  
R Robbins ◽  
S Schrepfer
Keyword(s):  
Immune Response ◽  
Host Immune Response ◽  
Kinetics Of

scholarly journals Human Norovirus Proteins: Implications in the Replicative Cycle, Pathogenesis, and the Host Immune Response

2020 ◽  
Vol 11 ◽  
Author(s):  
Claudia P. Campillay-Véliz ◽  
Jonatan J. Carvajal ◽  
Andrea M. Avellaneda ◽  
Darling Escobar ◽  
Camila Covián ◽  
...  
Keyword(s):  
Immune Response ◽  
Host Immune Response ◽  
Human Norovirus ◽  
Replicative Cycle

scholarly journals H-Ras gene takes part to the host immune response to COVID-19

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Salvatore Sciacchitano ◽  
Andrea Sacconi ◽  
Claudia De Vitis ◽  
Giovanni Blandino ◽  
Giulia Piaggio ◽  
...  
Keyword(s):  
Gene Expression ◽  
Immune Response ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Severe Disease ◽  
Host Immune Response ◽  
Severe Form ◽  
Ras Gene ◽  
Peripheral Blood Mononuclear ◽  
Ras Genes

AbstractRas gene family members play a relevant role in cancer, especially when they are mutated. However, they may play additional roles in other conditions beside cancer. We performed gene expression analysis using the NanoString PanCancer IO 360 panel in the peripheral blood mononuclear cell (PBMC) of six COVID-19 patients and we found that H-Ras gene was significantly upregulated, while both K-Ras and N-Ras genes were downregulated. In particular, H-Ras gene upregulation was more evident in COVID-19 patients with a more severe disease. We compared our results with those obtained by analyzing two different and independent datasets, including a total of 53 COVID-19 patients, in which the gene expression analysis was performed using the Immunology_V2 panel. Comparative analysis of the H-Ras gene expression in these patients confirmed our preliminary results. In both of them, in fact, we were able to confirm the upregulation of the expression of the H-Ras gene. The exact role of this specific upregulation of the H-Ras gene in response to SARS-CoV-2 infection and its possible role in cancer still remains to be elucidated. In conclusion, H-Ras gene participates to the host immune response to SARS-CoV-2 virus infection, especially in patients affected by the most severe form of the COVID-19.

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