scholarly journals The Relationship Between Coronary Arterial Plaque Burden and Lipid Pools: Histological Validation Using Near-Infrared Spectroscopy and Intravascular Ultrasound

2013 ◽  
Vol 22 ◽  
pp. S51
Author(s):  
J. Andrews ◽  
R. Puri ◽  
S. Madden ◽  
R. Madder ◽  
J. Muller ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Intravascular Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Plaque Burden ◽  
Arterial Plaque ◽  
The Relationship ◽  
Histological Validation

In vivo relationship between near-infrared spectroscopy-detected lipid-rich plaques and morphological plaque characteristics by optical coherence tomography and intravascular ultrasound: a multimodality intravascular imaging study

2020 ◽  
Author(s):  
Christian Zanchin ◽  
Yasushi Ueki ◽  
Sylvain Losdat ◽  
Gregor Fahrni ◽  
Joost Daemen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Infrared Spectroscopy ◽  
Intravascular Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Multimodality Imaging ◽  
Plaque Burden ◽  
Optical Coherence ◽  
Coronary Syndrome ◽  
Automated Method

Abstract Aims We assessed morphological features of near-infrared spectroscopy (NIRS)-detected lipid-rich plaques (LRPs) by using optical coherence tomography (OCT) and intravascular ultrasound (IVUS). Methods and results IVUS-NIRS and OCT were performed in the two non-infarct-related arteries (non-IRAs) in patients undergoing percutaneous coronary intervention for treatment of an acute coronary syndrome. A lesion was defined as the 4 mm segment with the maximum amount of lipid core burden index (maxLCBI4mm) of each LRP detected by NIRS. We divided the lesions into three groups based on the maxLCBI4mm value: <250, 250–399, and ≥400. OCT analysis and IVUS analysis were performed blinded for NIRS. We measured fibrous cap thickness (FCT) by using a semi-automated method. A total of 104 patients underwent multimodality imaging of 209 non-IRAs. NIRS detected 299 LRPs. Of those, 41% showed a maxLCBI4mm <250, 39% a maxLCBI4mm 251–399, and 19% a maxLCBI4mm ≥400. LRPs with a maxLCBI4mm ≥400, as compared with LRPs with a maxLCBI4mm 250–399 and <250, were more frequently thin-cap fibroatheroma (TCFA) (42.1% vs. 5.1% and 0.8%; P < 0.001) with a smaller minimum FCT (80 μm vs. 110 μm and 120 μm; P < 0.001); a higher IVUS-derived percent atheroma volume (53% vs. 53% and 44%; P < 0.001) and a higher remodelling index (1.08 vs. 1.02 and 1.01; P < 0.001). MaxLCBI4mm correlated with OCT-derived FCT (r = 0.404; P < 0.001) and was the best predictor for TCFA with an optimal cut-off value of 401 (area under the curve = 0.882; P < 0.001). Conclusion LRPs with increasing maxLCBI4mm exhibit OCT and IVUS features of presumed plaque vulnerability including TCFA morphology, increased plaque burden, and positive remodelling.

scholarly journals Influence of Myocardial Bridge On Atherosclerotic Plaque Distribution and Characteristics Evaluated By Near-Infrared Spectroscopy Intravascular Ultrasound

2021 ◽  
Author(s):  
Kan Saito ◽  
Hideki Kitahara ◽  
Takaaki Mastuoka ◽  
Naoto Mori ◽  
Kazuya Tateishi ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Intravascular Ultrasound ◽  
Near Infrared Spectroscopy ◽  
Atherosclerotic Plaque ◽  
Lipid Content ◽  
Near Infrared ◽  
Proximal Segment ◽  
Plaque Burden ◽  
Myocardial Bridge ◽  
Ivus Imaging

Abstract Purpose This study aims to clarify whether myocardial bridge (MB) could influence atherosclerotic plaque characteristics assessed by using near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) imaging. Methods One hundred and sixteen patients who underwent percutaneous coronary intervention (PCI) using NIRS-IVUS imaging were included. MB was defined as an echo-lucent band surrounding left anterior descending artery (LAD). In MB patients, LAD was divided into 3 segments: proximal, MB, and distal segments. In non-MB patients, corresponding 3 segments were defined based on the average length of the above segments. Segmental maximum plaque burden and lipid content derived from NIRS-IVUS imaging in the section of maximum plaque burden were evaluated in each segment. Lipid content of atherosclerotic plaque was evaluated as lipid core burden index (LCBI) and maxLCBI4mm. LCBI is the fraction of pixels indicating lipid within a region multiplied by 1000, and the maximum LCBI in any 4-mm region was defined as maxLCBI4mm. Results MB was identified in 42 patients. MB was not associated with maximum plaque burden in proximal segment. LCBI and maxLCBI4mm were significantly lower in patients with MB than those without in proximal segment. Multivariable analysis demonstrated both MB and maximum plaque burden in proximal segment to be independent predictors of LCBI in proximal segment. Conclusion Lipid content of atherosclerotic plaque assessed by NIRS-IVUS imaging was significantly smaller in patients with MB than those without. MB could be considered as a predictor of lipid content of atherosclerotic plaque when assessed by NIRS-IVUS imaging.

scholarly journals Vastus lateralis oxygenation during prolonged cycling in healthy males

2006 ◽  
Vol 31 (1) ◽  
pp. 48-55 ◽  
Author(s):  
Kotaro Kawaguchi ◽  
Yukiko Hayashi ◽  
Kiyokazu Sekikawa ◽  
Mitsuru Tabusadani ◽  
Tsutomu Inamizu ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Oxygen Uptake ◽  
Blood Volume ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Vastus Lateralis ◽  
Muscle Oxygenation ◽  
Cardiovascular Drift ◽  
Systemic Oxygen ◽  
The Relationship

This study examined the relationship between acute cardiorespiratory and muscle oxygenation and blood volume changes during prolonged exercise. Eight healthy male volunteers (mean maximum oxygen uptake ([Formula: see text]O2max) = 41.6 ± 2.4 mL/kg/min) performed 60 min submaximal cycling at 50% [Formula: see text]O2max. Oxygen uptake ([Formula: see text]O2) was measured by indirect spirometry, cardiac output (CO) was estimated using a PortapresTM, and right vastus lateralis oxyhemoglobin/ myoglobin (oxyHb/Mb), deoxyhemoglobin/myoglobin (deoxyHb/Mb), and total hemoglobin/myoglobin (total Hb/Mb) were recorded using near-infrared spectroscopy (NIRS). After 40 min of exercise, there was a significant increase in [Formula: see text]O2 due to a significantly higher arteriovenous oxygen difference ((a - v)O2diff). After 30 min of exercise CO remained unchanged, but there was a significant decrease in stroke volume and a proportionate increase in heart rate, thus indicating the occurrence of cardiovascular drift. During the first few minutes of exercise, there was a decline in oxyHb/Mb and total Hb/Mb, whereas deoxyHb/Mb remained unchanged. Thereafter, oxyHb/Mb and total Hb/Mb increased systematically until the termination of exercise while deoxyHb/Mb declined. After 40 min of exercise, these changes were significantly different from the baseline values. There were no significant correlations between the changes in the NIRS variables and systemic [Formula: see text]O2 or mixed (a - v)O2diff during exercise. These results suggest that factors other than localized changes in muscle oxygenation and blood volume account for the increased [Formula: see text]O2 during prolonged submaximal exercise. Key words: near infrared spectroscopy, cardiovascular drift, systemic oxygen consumption.

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