scholarly journals An artificial bile duct made of bioabsorbable polymer: a viable substitute for narrowed portion of the extrahepatic bile duct

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e524
Author(s):  
M. Miyazawa ◽  
M. Aikawa ◽  
K. Okada ◽  
Y. Watanabe ◽  
K. Ikamoto
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Bioabsorbable Polymer

AN ARTIFICIAL BILE DUCT MADE OF BIOABSORBABLE POLYMER CAN SERVE AS A SUBSTITUTE FOR NARROWED PORTIONS OF THE EXTRAHEPATIC BILE DUCT

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 47
Author(s):  
M Miyazawa ◽  
M Aikawa ◽  
Y Toshimitsu ◽  
K Okada ◽  
K Okamoto ◽  
...  
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Bioabsorbable Polymer

scholarly journals An Artificial Bile Duct Made of Bioabsorbable Polymer: A Viable Substitute for Narrowed Portion of the Extrahepatic Bile Duct

2015 ◽  
Vol 100 (11-12) ◽  
pp. 1408-1413 ◽  
Author(s):  
Mitsuo Miyazawa ◽  
Masayasu Aikawa ◽  
Katsuya Okada ◽  
Yukihiro Watanabe ◽  
Kojun Okamoto ◽  
...  
Keyword(s):  
Bile Duct ◽  
General Anesthesia ◽  
Polylactic Acid ◽  
Cystic Duct ◽  
Total Bilirubin ◽  
Extrahepatic Bile Duct ◽  
Bioabsorbable Polymer ◽  
Anastomosis Site ◽  
Chemical Studies ◽  
Post Implantation

The aim of this study was to investigate whether an artificial bile duct made of bioabsorbable polymer could serve as a substitute for narrowed portions of the bile duct. The experiments were performed using hybrid pigs (n = 11). After laparotomy under general anesthesia, the extrahepatic bile duct was identified and ligated around the confluence with the cystic duct. A week later, repeat laparotomy was performed on the animals, and the bile duct on the hepatic side of the ligature was resected. The cut end was connected to the duodenum using a bioabsorbable artificial bile duct fabricated from a copolymer of polycaprolactone and polylactic acid fibers. The grafts were recovered for gross, histologic, and blood chemical studies at 4 months after the surgery. All recipient pigs survived until they were humanely killed for collection of the implants. A week of ligation of the extrahepatic bile duct dilated the duct to approximately 1 cm in diameter and increased total bilirubin. Total bilirubin had returned to the pre-implantation level in all animals at 4 months post implantation. Examinations of the grafts revealed complete freedom of stricture and the regeneration of a neo-bile duct of approximately 1 cm in diameter from the graft site in 10 of 11 animals. Gross observation of the graft from the 1 remaining animal revealed stricture at the anastomosis site and poor bile duct epithelization. We have concluded that this bioabsorbable polymer bile duct can serve as a replacement for narrowed portions of the bile duct.

Novel reconstruction of the extrahepatic bile duct with a tissue-engineered bioabsorbable polymer graft

2015 ◽  
Vol 221 (4) ◽  
pp. e101
Author(s):  
Xulong Zhu ◽  
Qingdong Gao ◽  
Weijie Yao ◽  
Xiaopeng Yan ◽  
Junxi Xiang ◽  
...  
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Bioabsorbable Polymer

An Extrahepatic Bile Duct Grafting Using a Bioabsorbable Polymer Tube

2012 ◽  
Vol 16 (3) ◽  
pp. 529-534 ◽  
Author(s):  
Masayasu Aikawa ◽  
Mitsuo Miyazawa ◽  
Kojun Okamoto ◽  
Yasuko Toshimitsu ◽  
Katsuya Okada ◽  
...  
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Bioabsorbable Polymer ◽  
Polymer Tube

scholarly journals GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lucas D. Ward ◽  
Ho-Chou Tu ◽  
Chelsea B. Quenneville ◽  
Shira Tsour ◽  
Alexander O. Flynn-Carroll ◽  
...  
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Association Studies ◽  
Missense Variant ◽  
Deficiency Anemia ◽  
Genome Wide Association Studies ◽  
Loss Of Function ◽  
Extrahepatic Bile Duct Cancer ◽  
Hepatocellular Damage ◽  
Increased Risk

AbstractUnderstanding mechanisms of hepatocellular damage may lead to new treatments for liver disease, and genome-wide association studies (GWAS) of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum activities have proven useful for investigating liver biology. Here we report 100 loci associating with both enzymes, using GWAS across 411,048 subjects in the UK Biobank. The rare missense variant SLC30A10 Thr95Ile (rs188273166) associates with the largest elevation of both enzymes, and this association replicates in the DiscovEHR study. SLC30A10 excretes manganese from the liver to the bile duct, and rare homozygous loss of function causes the syndrome hypermanganesemia with dystonia-1 (HMNDYT1) which involves cirrhosis. Consistent with hematological symptoms of hypermanganesemia, SLC30A10 Thr95Ile carriers have increased hematocrit and risk of iron deficiency anemia. Carriers also have increased risk of extrahepatic bile duct cancer. These results suggest that genetic variation in SLC30A10 adversely affects more individuals than patients with diagnosed HMNDYT1.

scholarly journals Etiological classification and treatment strategies for secondary bile duct dilatation

2020 ◽  
pp. 153537022096676
Author(s):  
Yunfu Lv ◽  
Ning Liu ◽  
Hongfei Wu ◽  
Zhuori Li
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Treatment Strategies ◽  
Extensive Literature ◽  
Common Condition ◽  
Endoscopic Dilation ◽  
Biliary Strictures ◽  
Bile Duct Dilatation ◽  
Duct Dilatation ◽  
Classification And Treatment

Secondary intra- and extrahepatic bile duct dilatation is a very common condition that can be caused by several diseases. However, it has been rarely discussed in the specialized literature. Moreover, no distinct etiology can be determined in some cases, which hampers the diagnosis and treatment. Here, we discuss the etiological classification and treatment strategies of secondary intra- and extrahepatic bile duct dilatation based on an extensive literature review, as well as our experimental research and clinical experience. The etiology of secondary intra- and extrahepatic bile duct dilatation can be classified in different ways. From a clinicopathological perspective, it can be classified into obstruction-, lesion-, and compression-induced dilatation. Treatment varies depending on the cause. For example, endoscopic dilation or stenting is used for biliary strictures, laparoscopic choledochectomy for stone removal, and resection for cholangiocarcinoma.

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