GLRLM features in CT texture analysis are prognostic factors: Evaluation of pancreatic cancer heterogeneity, retrospective cohort study

Objectives The prognosis of people with pancreatic cancer is extremely unfavorable. However, the prognostic factors remain largely undefined. We aimed to perform comprehensive analyses of clinicopathologic characteristics, laboratory parameters, and treatment protocols for exploring their role as prognostic factors of pancreatic cancer. Methods Patients diagnosed with pancreatic cancer and hospitalized at the China National Cancer Center between April 2006 and May 2016 were enrolled in this retrospective cohort study. Clinicopathologic characteristics, laboratory parameters, and treatment protocols were compared among patients at different stages of the disease. The association between these factors and overall survival (OS) was analyzed using the Kaplan–Meier method and Cox proportional hazards model. Results The present study included 1,433 consecutive patients with pancreatic cancer. Median OS was 10.6 months (95% confidence interval [CI] 9.8–11.3 months), with 1-, 3-, and 5-year survival rates of 43.7%, 14.8%, and 8.8%, respectively. Cox multivariate analysis findings identified the following factors as independent predictors of OS: gender (female vs male, hazard ratio 0.72, 95% CI [0.54–0.95]); elevated total bilirubin (TBil; 1.82, 1.34–2.47); elevated carbohydrate antigen 19-9 (CA19-9; 1.72, 1.17–2.54); tumor being located in pancreatic body and tail (1.52, 1.10–2.10); advanced T stage (T3-4 vs T1-2, 1.62, 1.15–2.27); lymph node metastasis (1.57, 1.20–2.07); distant metastasis (1.59, 1.12–2.27); the presence of surgical resection (0.53, 0.34–0.81); and the presence of systemic chemotherapy (0.62, 0.45–0.82). Conclusions Being male, elevated TBil and carcinoembryonic antigen, tumor being located in pancreatic body and tail, advanced T stage, lymph node and distant metastasis, the absence of surgical resection, and the absence of systematic chemotherapy were associated with worse OS in patients with pancreatic cancer.

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Which prognostic factors are important for long-term outcomes in symptomatic obstructive colon cancer? A multi-institutional retrospective cohort study

Journal of Minimally Invasive Surgery ◽

10.7602/jmis.2021.24.3.128 ◽

2021 ◽

Vol 24 (3) ◽

pp. 128-138 ◽

Cited By ~ 1

Author(s):

Chang Hwan Kim ◽

Jung Hoon Bae ◽

Chul Seung Lee ◽

Seung-Rim Han ◽

In Kyu Lee ◽

...

Keyword(s):

Colon Cancer ◽

Cohort Study ◽

Prognostic Factors ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Long Term Outcomes

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Prognostic factors of Candida spp. bloodstream infection in adults: A nine-year retrospective cohort study across tertiary hospitals in Brazil and Spain

The Lancet Regional Health - Americas ◽

10.1016/j.lana.2021.100117 ◽

2021 ◽

pp. 100117

Author(s):

Caroline Agnelli ◽

Maricela Valerio ◽

Emilio Bouza ◽

Jesús Guinea ◽

Teresa Sukiennik ◽

...

Keyword(s):

Cohort Study ◽

Prognostic Factors ◽

Bloodstream Infection ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Candida Spp ◽

Tertiary Hospitals

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Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01701-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Pascale Bemer ◽

Olivia Peuchant ◽

Hélène Guet-Revillet ◽

Julien Bador ◽

Charlotte Balavoine ◽

...

Keyword(s):

Cohort Study ◽

Prognostic Factors ◽

Mycobacterium Avium ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Cox Regression ◽

Nontuberculous Mycobacteria ◽

Great Variability ◽

Microbiological Characteristics ◽

Smear Negative

Abstract Background Recent studies report very low adherence of practitioners to ATS/IDSA recommendations for the treatment of nontuberculous mycobacteria pulmonary disease (NTM-PD), as well as a great variability of practices. Type of management could impact prognosis. Methods To evaluate management and prognosis of patients with NTM-PD cases with respect to ATS recommendations, we conducted a multicenter retrospective cohort study (18 sentinel sites distributed throughout France), over a period of six years. We collected clinical, radiological, microbiological characteristics, management and outcome of the patients (especially death or not). Results 477 patients with NTM-PD were included. Respiratory comorbidities were found in 68% of cases, tuberculosis sequelae in 31.4% of patients, and immunosuppression in 16.8% of cases. The three most common NTM species were Mycobacterium avium complex (60%), M. xenopi (20%) and M. kansasii (5.7%). Smear-positive was found in one third of NTM-PD. Nodulobronchiectatic forms were observed in 54.3% of cases, and cavitary forms in 19.1% of patients. Sixty-three percent of patients were treated, 72.4% of patients with smear-positive samples, and 57.5% of patients with smear-negative samples. Treatment was in adequacy with ATS guidelines in 73.5%. The 2-year mortality was 14.4%. In the Cox regression, treatment (HR = 0.51), age (HR = 1.02), and M. abscessus (3.19) appeared as the 3 significant independent prognostic factors. Conclusion These findings highlight the adequacy between French practices and the ATS/IDSA guidelines. Treatment was associated with a better survival.

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Retrospective cohort study of prognostic factors in patients with oral cavity and oropharyngeal squamous cell carcinoma

Head & Neck ◽

10.1002/hed.23914 ◽

2015 ◽

Vol 38 (4) ◽

pp. 536-541 ◽

Cited By ~ 14

Author(s):

José F. Carrillo ◽

Liliana C. Carrillo ◽

Ana Cano ◽

Margarita C. Ramirez-Ortega ◽

Jorge G. Chanona ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cohort Study ◽

Prognostic Factors ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Oropharyngeal Squamous Cell Carcinoma

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Correction to: Outcomes After Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer: A Pan-European Retrospective Cohort Study

Annals of Surgical Oncology ◽

10.1245/s10434-018-6442-5 ◽

2018 ◽

Vol 25 (S3) ◽

pp. 988-988 ◽

Cited By ~ 1

Author(s):

Sjors Klompmaker ◽

◽

Jony van Hilst ◽

Sarah L. Gerritsen ◽

Mustapha Adham ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cohort Study ◽

Distal Pancreatectomy ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Celiac Axis

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Perioperative glucocorticoids are associated with improved long-term survival after pancreatic cancer surgery: A retrospective cohort study

10.21203/rs.3.rs-20131/v1 ◽

2020 ◽

Author(s):

Yun-Xiao Zhang ◽

Dong-Liang Mu ◽

Ke-Min Jin ◽

Xue-Ying Li ◽

Dong-Xin Wang

Keyword(s):

Pancreatic Cancer ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Radical Surgery ◽

Radical Resection ◽

Cancer Surgery ◽

Term Survival ◽

Long Term Survival

Abstract Background Perioperative anesthetic management may affect long-term outcome after cancer surgery. This study aimed to investigate the effect of perioperative glucocorticoids on long-term survival in patients after radical resection for pancreatic cancer.Methods In this retrospective cohort study, patients who underwent radical resection for pancreatic cancer from January 2005 to December 2016 were recruited. Baseline and perioperative data including use of glucocorticoids for prevention of postoperative nausea and vomiting were collected. Patients were followed up for tumor recurrence and survival. The primary outcome was the overall survival (OS); the secondary outcome was the recurrence-free survival (RFS). A multivariable Cox proportional hazard model was used to analyze the influence of perioperative glucocorticoid use on OS and RFS after correction for confounding factors.Results A total of 215 patients after radical surgery for pancreatic cancer were included in the study; of these, 112 received perioperative glucocorticoids and 103 did not. Patients were followed up for a median of 74.0 months (95% confidence interval [CI] 68.3-79.7). Both OS and RFS were significantly longer in patients with glucocorticoids than in those without (for OS: median 19.7 months [95% CI 12.3-36.2] vs. 13.9 months [8.0-23.9], P=0.001; for RFS: 12.0 months [6.0-28.0] vs. 6.9 months [4.2-17.0], P=0.002). After correction for confounding factors, perioperative glucocorticoids were significantly associated with prolonged OS (HR 0.692, 95% CI 0.499-0.959, P=0.027) and RFS (HR 0.634, 95% CI 0.459-0.878, P=0.006).Conclusions Perioperative use of low-dose glucocorticoids may improve long-term survival in patients undergoing radical surgery for pancreatic cancer.

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