scholarly journals Prognostic factors of Candida spp. bloodstream infection in adults: A nine-year retrospective cohort study across tertiary hospitals in Brazil and Spain

2021 ◽  
pp. 100117
Author(s):  
Caroline Agnelli ◽  
Maricela Valerio ◽  
Emilio Bouza ◽  
Jesús Guinea ◽  
Teresa Sukiennik ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Bloodstream Infection ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Candida Spp ◽  
Tertiary Hospitals

scholarly journals Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Pascale Bemer ◽  
Olivia Peuchant ◽  
Hélène Guet-Revillet ◽  
Julien Bador ◽  
Charlotte Balavoine ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Mycobacterium Avium ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cox Regression ◽  
Nontuberculous Mycobacteria ◽  
Great Variability ◽  
Microbiological Characteristics ◽  
Smear Negative

Abstract Background Recent studies report very low adherence of practitioners to ATS/IDSA recommendations for the treatment of nontuberculous mycobacteria pulmonary disease (NTM-PD), as well as a great variability of practices. Type of management could impact prognosis. Methods To evaluate management and prognosis of patients with NTM-PD cases with respect to ATS recommendations, we conducted a multicenter retrospective cohort study (18 sentinel sites distributed throughout France), over a period of six years. We collected clinical, radiological, microbiological characteristics, management and outcome of the patients (especially death or not). Results 477 patients with NTM-PD were included. Respiratory comorbidities were found in 68% of cases, tuberculosis sequelae in 31.4% of patients, and immunosuppression in 16.8% of cases. The three most common NTM species were Mycobacterium avium complex (60%), M. xenopi (20%) and M. kansasii (5.7%). Smear-positive was found in one third of NTM-PD. Nodulobronchiectatic forms were observed in 54.3% of cases, and cavitary forms in 19.1% of patients. Sixty-three percent of patients were treated, 72.4% of patients with smear-positive samples, and 57.5% of patients with smear-negative samples. Treatment was in adequacy with ATS guidelines in 73.5%. The 2-year mortality was 14.4%. In the Cox regression, treatment (HR = 0.51), age (HR = 1.02), and M. abscessus (3.19) appeared as the 3 significant independent prognostic factors. Conclusion These findings highlight the adequacy between French practices and the ATS/IDSA guidelines. Treatment was associated with a better survival.

Retrospective cohort study of prognostic factors in patients with oral cavity and oropharyngeal squamous cell carcinoma

Head & Neck ◽  
2015 ◽  
Vol 38 (4) ◽  
pp. 536-541 ◽  
Author(s):  
José F. Carrillo ◽  
Liliana C. Carrillo ◽  
Ana Cano ◽  
Margarita C. Ramirez-Ortega ◽  
Jorge G. Chanona ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cohort Study ◽  
Prognostic Factors ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Oropharyngeal Squamous Cell Carcinoma

scholarly journals Clinicopathologic characteristics, laboratory parameters, treatment protocols, and outcomes of pancreatic cancer: a retrospective cohort study of 1433 patients in China

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4893 ◽  
Author(s):  
Shuisheng Zhang ◽  
Xiaozhun Huang ◽  
Yuan Tian ◽  
Saderbieke Aimaiti ◽  
Jianwei Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cohort Study ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Distant Metastasis ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Clinicopathologic Characteristics ◽  
Treatment Protocols ◽  
Laboratory Parameters

Objectives The prognosis of people with pancreatic cancer is extremely unfavorable. However, the prognostic factors remain largely undefined. We aimed to perform comprehensive analyses of clinicopathologic characteristics, laboratory parameters, and treatment protocols for exploring their role as prognostic factors of pancreatic cancer. Methods Patients diagnosed with pancreatic cancer and hospitalized at the China National Cancer Center between April 2006 and May 2016 were enrolled in this retrospective cohort study. Clinicopathologic characteristics, laboratory parameters, and treatment protocols were compared among patients at different stages of the disease. The association between these factors and overall survival (OS) was analyzed using the Kaplan–Meier method and Cox proportional hazards model. Results The present study included 1,433 consecutive patients with pancreatic cancer. Median OS was 10.6 months (95% confidence interval [CI] 9.8–11.3 months), with 1-, 3-, and 5-year survival rates of 43.7%, 14.8%, and 8.8%, respectively. Cox multivariate analysis findings identified the following factors as independent predictors of OS: gender (female vs male, hazard ratio 0.72, 95% CI [0.54–0.95]); elevated total bilirubin (TBil; 1.82, 1.34–2.47); elevated carbohydrate antigen 19-9 (CA19-9; 1.72, 1.17–2.54); tumor being located in pancreatic body and tail (1.52, 1.10–2.10); advanced T stage (T3-4 vs T1-2, 1.62, 1.15–2.27); lymph node metastasis (1.57, 1.20–2.07); distant metastasis (1.59, 1.12–2.27); the presence of surgical resection (0.53, 0.34–0.81); and the presence of systemic chemotherapy (0.62, 0.45–0.82). Conclusions Being male, elevated TBil and carcinoembryonic antigen, tumor being located in pancreatic body and tail, advanced T stage, lymph node and distant metastasis, the absence of surgical resection, and the absence of systematic chemotherapy were associated with worse OS in patients with pancreatic cancer.

Prognostic Factors Associated with Hospital Stay in Patients Undergoing Emergency Cholecystectomy: Retrospective Cohort Study

2019 ◽  
Vol 229 (4) ◽  
pp. e124-e125
Author(s):  
Pilar C. Pinillos Navarro ◽  
Jorge A. Martínez Martínez ◽  
Edgar G. Junca ◽  
Andrés F. Patiño ◽  
Juan S. Moyano ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Hospital Stay ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Factors Associated ◽  
Emergency Cholecystectomy

Prognostic factors for the loss of molars - an 18-years retrospective cohort study

2015 ◽  
Vol 42 (10) ◽  
pp. 943-950 ◽  
Author(s):  
Christian Graetz ◽  
Svenja Schützhold ◽  
Anna Plaumann ◽  
Maren Kahl ◽  
Claudia Springer ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort

Epidemiologic Investigation of a 2007 Outbreak of Serratia marcescens Bloodstream Infection in Texas Caused by Contamination of Syringes Prefilled With Heparin and Saline

2009 ◽  
Vol 30 (6) ◽  
pp. 593-595 ◽  
Author(s):  
John R. Su ◽  
David B. Blossom ◽  
Wendy Chung ◽  
Jessica Smartt Gullion ◽  
Neil Pascoe ◽  
...  
Keyword(s):  
Cohort Study ◽  
Serratia Marcescens ◽  
Bloodstream Infection ◽  
Retrospective Cohort Study ◽  
Outpatient Treatment ◽  
Retrospective Cohort ◽  
Epidemiologic Study ◽  
Epidemiologic Studies ◽  
Treatment Center ◽  
Epidemiologic Investigation

This retrospective cohort study found that syringes prefilled with heparin flush solution caused an outbreak of Serratia marcescens bloodstream infection at an outpatient treatment center in Texas in 2007. The epidemiologic study supported this conclusion, despite the lack of microbiologic evidence of contamination from environmental and product testing. This report underscores the crucial contributions that epidemiologic studies can make to investigations of outbreaks that are possibly product related.

scholarly journals Prognostic value of lymphocyte-to-monocyte ratio and neutrophil-to-lymphocyte ratio in follicular lymphoma: a retrospective cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e017904 ◽  
Author(s):  
Shing Fung Lee ◽  
Miguel Angel Luque-Fernandez
Keyword(s):  
Cohort Study ◽  
Prognostic Factors ◽  
Follicular Lymphoma ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Lymphocyte To Monocyte Ratio

ObjectivesThe clinical course and prognosis of follicular lymphoma (FL) are diverse and associated with the patient’s immune response. We investigated the lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR) as prognostic factors in patients with FL, including those receiving radiotherapy.DesignA retrospective cohort study.SettingRegional cancer centre in Hong Kong.Participants88 patients with histologically proven FL diagnosed between 2000 and 2014.Materials and methodsThe best LMR and NLR cut-off values were determined using cross-validated areas under the receiver operating characteristic curves. The extent to which progression-free survival (PFS) and overall survival differed by NLR and LMR cut-off values was assessed using Kaplan-Meier analysis and log-rank tests. A Cox proportional hazards model was fitted to adjust for confounders.ResultsThe best cut-off values for LMR and NLR were 3.20 and 2.18, respectively. The 5-year PFS was 73.6%. After multivariate adjustment, high LMR (>3.20) at diagnosis was associated with superior PFS, with a HR of 0.31 (95% CI 0.13 to 0.71), whereas high NLR at relapse was associated with poorer postprogression survival (HR 1.24, 95% CI 1.04 to 1.49).ConclusionsBaseline LMR and NLR at relapse were shown to be independent prognostic factors in FL. LMR and NLR are cheap and widely available biomarkers that could be used in combination with the Follicular Lymphoma International Prognostic Index by clinicians to better predict prognosis.

Sign in / Sign up

Export Citation Format

Share Document