Prognostic role of CD8+ tumor-infiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability

2004 ◽  
Vol 35 (7) ◽  
pp. 808-816 ◽  
Author(s):  
F PRALL
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Tumor Infiltrating Lymphocytes ◽  
Stage Iii ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals Clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer

2019 ◽  
Vol 34 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Young San Ko ◽  
Jung-Soo Pyo
Keyword(s):  
Colorectal Cancer ◽  
Immune Cells ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Significant Difference ◽  
Clinicopathological Significance ◽  
Cancer Tissues ◽  
Infiltrating Lymphocytes ◽  
The Impact

Purpose: This study aimed to elucidate the clinicopathological significance and prognostic role of tumor-infiltrating lymphocytes in colorectal cancer. Methods: The immunohistochemistry of CD3 and CD8 was performed on 265 human colorectal cancer tissues to investigate the tumor-infiltrating lymphocytes using Immunoscore. The correlation between Immunoscore and clinicopathological characteristics, including survival rates, was elucidated. In addition, the impact of tumor-infiltrating lymphocytes on programmed death-ligand 1 (PD-L1) protein expression was evaluated through immunohistochemistry. Results: Of the 265 colorectal cancer tissues, 40.8% had high Immunoscore, while 59.2% had low Immunoscore. A high Immunoscore was significantly correlated with favorable tumor behaviors, including lower rates of vascular, lymphatic, and perineural invasion; lymph node metastasis; and distant metastasis. PD-L1 expressions of tumor and immune cells were significantly higher in patients with high Immunoscore than in those with low Immunoscore. In addition, colorectal cancer tissues with high CD8-positive lymphocytes showed higher PD-L1 expressions of tumor and immune cells than colorectal cancer tissues with low CD8-positive lymphocytes. There was a significant correlation between high Immunoscore and better overall survival. However, there was no significant difference in survival rate according to PD-L1 expressions of tumor and immune cells in high and low Immunoscore subgroups. Conclusions: Taken together, our results showed that high tumor-infiltrating lymphocytes were significantly correlated with favorable tumor behaviors and better survival. In addition, there was a significant correlation between PD-L1 expression and tumor-infiltrating lymphocytes.

scholarly journals Prognostic Role of Tumor‐Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma

2021 ◽  
Author(s):  
Yukiko Hori ◽  
Akira Kubota ◽  
Tomoyuki Yokose ◽  
Madoka Furukawa ◽  
Takeshi Matsushita ◽  
...  
Keyword(s):  
Tumor Infiltrating Lymphocytes ◽  
Tumor Budding ◽  
Tongue Carcinoma ◽  
Oral Tongue ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals Role of the Pathologist in the Diagnosis of Hereditary Non-Polyposis Colorectal Cancer

2004 ◽  
Vol 20 (4-5) ◽  
pp. 215-224 ◽  
Author(s):  
Jeremy R. Jass
Keyword(s):  
Colorectal Cancer ◽  
Mismatch Repair ◽  
Tumor Infiltrating Lymphocytes ◽  
Dna Mismatch ◽  
Repair Deficiency ◽  
Dna Mismatch Repair Genes ◽  
Histological Criteria ◽  
Dna Microsatellite ◽  
Infiltrating Lymphocytes

The aim of this paper is to indicate how the pathologist may suspect a diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) on the basis of histological criteria and patient age alone. A single morphological feature, namely the presence of intra-epithelial lymphocytes (tumor infiltrating lymphocytes), identifies the majority of colorectal cancers (CRC) with the DNA microsatellite instability-high phenotype. A number of pathological criteria can help to distinguish HNPCC from sporadic MSI-H CRC, though age below 60 years is an important pointer towards HNPCC. Immunohistochemistry to demonstrate loss of expression of DNA mismatch repair genes serves as a highly reliable test of mismatch repair deficiency if antibodies to hMLH1, hMSH2, hMSH6 and hPMS2 are employed.

Prognostic role of tumor infiltrating lymphocytes in EBV positive and EBV negative nasopharyngeal carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 71 ◽  
pp. 16-25 ◽  
Author(s):  
Marc L. Ooft ◽  
Jolique A. van Ipenburg ◽  
Weibel W. Braunius ◽  
Charlotte I. Zuur ◽  
Senada Koljenović ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals Prognostic role of tumor-infiltrating lymphocytes in gastric cancer

Medicine ◽  
2018 ◽  
Vol 97 (32) ◽  
pp. e11769 ◽  
Author(s):  
Jung Soo Lee ◽  
Hye Sung Won ◽  
Der Sheng Sun ◽  
Ji Hyung Hong ◽  
Yoon Ho Ko
Keyword(s):  
Gastric Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Prognostic Role ◽  
Infiltrating Lymphocytes

scholarly journals The Prognostic Value of Sex-Determining Region Y-Box 2 and CD8+ Tumor-Infiltrating Lymphocytes in Limited-Stage Small-Cell Lung Cancer

Oncology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Jinsoo Lee ◽  
Yoon Yang Jung ◽  
Jung Hoon Lee ◽  
Mineui Hong ◽  
Hye-Won Hwang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Prognostic Value ◽  
Tumor Infiltrating Lymphocytes ◽  
Small Cell ◽  
Small Cell Lung ◽  
Prognostic Role ◽  
Sox2 Expression ◽  
Infiltrating Lymphocytes

<b><i>Background:</i></b> Sex-determining region Y-box 2 (SOX2) is a transcriptional factor that drives embryonic stem cells to neuroendocrine cells in lung development and is highly expressed in small-cell lung cancer (SCLC). However, the prognostic role of SOX2 and its relationship with tumor-infiltrating lymphocytes (TILs) has not been determined in SCLC. Herein, we assessed the expression of SOX2 and CD8+ TILs to obtain insights into the prognostic role of SOX2 and CD8+ TILs in limited-stage (LS)-SCLC. <b><i>Methods:</i></b> A total of 75 patients with LS-SCLC was enrolled. The SOX2 expression and CD8+ TILs were evaluated by immunohistochemistry. <b><i>Results:</i></b> High SOX2 and CD8+ TIL levels were identified in 52 (69.3%) and 40 (53.3%) patients, respectively. High SOX2 expression was correlated with increased density of CD8+ TILs (<i>p</i> = 0.041). Unlike SOX2, high CD8+ TIL numbers were associated with significantly longer progression-free survival (PFS; 13.9 vs. 8.0 months, <i>p</i> = 0.014). Patients with both high SOX2 expression and CD8+ TIL numbers (<i>n</i> = 29, 38.7%) had significantly longer PFS and overall survival (OS) compared to those from the other groups (median PFS 19.3 vs. 8.4 months; <i>p</i> = 0.002 and median OS 35.7 vs. 17.4 months; <i>p</i> = 0.004, respectively). Multivariate Cox regression analysis showed that the combination of high SOX2 expression and CD8+ TIL levels was an independent good prognostic factor for OS (HR = 0.471, 95% CI, 0.250–0.887, <i>p</i> = 0.02) and PFS (HR = 0.447, 95% CI, 0.250–0.801, <i>p</i> = 0.007) in SCLC. <b><i>Conclusions:</i></b> Evaluation of the combination of SOX2 and CD8+ TIL levels may be of a prognostic value in LS-SCLC.

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