Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications

2006 ◽  
Vol 37 (11) ◽  
pp. 1371-1388 ◽  
Author(s):  
A LOPEZBELTRAN ◽  
L CHENG
Keyword(s):  
Differential Diagnosis ◽  
Urothelial Carcinoma ◽  
Clinical Implications

Neurogenic Polyps of the Gastrointestinal Tract: A Clinicopathologic Review With Emphasis on Differential Diagnosis and Syndromic Associations

2015 ◽  
Vol 139 (1) ◽  
pp. 133-139 ◽  
Author(s):  
Jaclyn F. Hechtman ◽  
Noam Harpaz
Keyword(s):  
Differential Diagnosis ◽  
Gastrointestinal Tract ◽  
Accurate Diagnosis ◽  
Gastrointestinal System ◽  
Clinical Implications ◽  
Molecular Features

Primary neurogenic gastrointestinal polyps are encountered relatively frequently in routine pathology practice. They encompass a variety of neoplastic entities with clinical, morphologic, and molecular features that reflect the diversity of neural elements within the gastrointestinal system. Although most are benign and encountered incidentally, accurate diagnosis may have important clinical implications because of the associations of certain neurogenic polyps with familial syndromes or other conditions. We review the pathology of these polyps with an emphasis on the diagnostic challenges that they pose and on newly described subtypes.

scholarly journals Somatically derived Yolk Sac tumor of the urinary bladder: A case report and differential diagnosis

2020 ◽  
Author(s):  
Nadia Espejo-Herrera ◽  
Enric Condom Mundó
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Urinary Bladder ◽  
Urothelial Carcinoma ◽  
Final Diagnosis ◽  
Yolk Sac ◽  
Yolk Sac Tumor ◽  
High Grade ◽  
Yolk Sac Tumors ◽  
Urinary Bladder Tumor

Abstract Background: Yolk sac tumor is a germ cell neoplasm that arises predominantly in the gonads, but can also derive from somatic neoplasms in extragonadal locations. These cases have been denominated recently as “somatically derived Yolk sac tumors”, and have been documented in several locations, although reports from the urinary tract are scarce. To our knowledge, this is the first report of a Yolk sac tumor derived from urothelial carcinoma. Case presentation: We present a unique case of a 76-year-old man with a recurrent urinary bladder tumor, initially interpreted as a high grade urothelial carcinoma with glandular differentiation. In the recurrent tumor, diverse histological patterns were identified, including glandular, hepatoid and sarcomatoid. This tumor showed positivity for AFP, GLP3 and SALL4, and negativity for CK7 and EMA. Fluorescent in situ hybridization study showed a polysomic pattern of chromosome 12. All these findings led to the final diagnosis of a Yolk sac tumor derived from urothelial carcinoma. Conclusions: Somatically derived Yolk Sac tumors should be considered in the differential diagnosis of a high grade urothelial carcinoma, particularly when glandular and other unusual patterns are observed. Key words: Yolk sac tumor, somatically derived, urothelial carcinoma, urinary bladder, case report.

Treatment options for deciduous molar hypomineralization: a report of three cases

Dental Update ◽  
2019 ◽  
Vol 46 (6) ◽  
pp. 546-553
Author(s):  
Yasmy Quintero ◽  
Manuel Restrepo ◽  
Jenny Angélica Saldarriaga ◽  
Alexandra Saldarriaga ◽  
Lourdes Santos-Pinto
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Treatment Options ◽  
Clinical Implications ◽  
Therapeutic Approaches ◽  
Enamel Defect ◽  
Delayed Treatment ◽  
Molar Incisor Hypomineralization ◽  
Permanent Molars ◽  
Deciduous Molar

Deciduous molar hypomineralization (DMH) is an enamel defect of systemic and multifactorial origin that affects the second deciduous molar. Currently, its treatment is based on guidelines for Molar Incisor Hypomineralization (MIH), a disturbance that affects permanent molars and may or may not be associated with permanent incisors. To date, there are no guidelines for DMH. Therefore, three different therapeutic approaches are presented to treat DMH, emphasizing the relevance of early diagnosis, differential diagnosis and treatment options, and tailored to take into account each patient's and parents' specific needs, as well as the involved tooth, severity of DMH, patients' symptoms and behaviour. CPD/Clinical Relevance: To understand the clinical implications of DMH since the diagnosis and delayed treatment of this enamel alteration could have important complications in both the primary and permanent dentition.

scholarly journals Histologic Variants of Urothelial Carcinoma: Morphology, Molecular Features and Clinical Implications

2020 ◽  
Vol 6 (2) ◽  
pp. 107-122 ◽  
Author(s):  
Meera Alderson ◽  
Petros Grivas ◽  
Matthew I. Milowsky ◽  
Sara E. Wobker
Keyword(s):  
Urothelial Carcinoma ◽  
Clinical Implications ◽  
Molecular Features

Immunohistochemistry as an adjunct in the differential diagnosis of radiation-induced atypia versus urothelial carcinoma in situ of the bladder: a study of 45 cases

2013 ◽  
Vol 44 (5) ◽  
pp. 860-866 ◽  
Author(s):  
Esther Oliva ◽  
Nathanael F. Pinheiro ◽  
Niall M. Heney ◽  
Donald S. Kaufman ◽  
William U. Shipley ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Urothelial Carcinoma ◽  
Carcinoma In Situ ◽  
Radiation Induced

scholarly journals High-Grade Carcinomas Involving the Renal Sinus: Report of a Case and Review of the Differential Diagnosis and Immunohistochemical Expression

2012 ◽  
Vol 136 (8) ◽  
pp. 907-910 ◽  
Author(s):  
Allison Young ◽  
Lakshmi P. Kunju
Keyword(s):  
Renal Cell Carcinoma ◽  
Differential Diagnosis ◽  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Collecting Duct ◽  
Upper Urinary Tract ◽  
High Grade ◽  
Renal Sinus

We report the case of a high-grade carcinoma involving the kidney in a young male with renal vein thrombosis and review the differential diagnosis and immunohistochemical workup. High-grade neoplasms involving the renal sinus include collecting duct carcinomas (CDCs), renal medullary carcinomas (RMCs), invasive high-grade urothelial carcinoma (UC) of the upper urinary tract, clear cell renal cell carcinoma, and type 2 papillary renal cell carcinoma. Distinguishing UC from CDC and RMC is problematic in small biopsy samples. The diagnosis of CDC (a rare, aggressive subtype of renal cell carcinoma) is challenging and requires the exclusion of UC. Renal medullary carcinoma is characterized by an appropriate clinical setting and consistent loss of nuclear expression of integrase interactor 1 (INI-1). A panel consisting of p63, paired box gene 8 (PAX8), and INI-1 is most optimal in distinguishing UC from CDC and RMC. A subset of urothelial carcinoma of upper urinary tract may be positive with PAX8.

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