Squamoid morules in the pseudoinvasive foci of colonic polyp morphologically mimic invasive carcinoma

Paget’s disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. It is often misdiagnosed as eczema of breast and treatment is delayed. Here we present a case where a 30 year old female presented with itching ulceration and destruction of her left nipple. She was treated initially by local physicians by applying local ointments but as her condition did not improve she was admitted to department of surgery Shaheed Suhrawardy Medical College hospital where she was diagnosed as Paget’s disease with infiltrating ductal cell carcinoma. She underwent modified radical mastectomy with axillary clearance and referred to oncology department for further management. J Shaheed Suhrawardy Med Coll, June 2019, Vol.11(1); 81-83

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Disease-free long survival after stump recurrence and reoperation of pancreatic IPMN with invasive carcinoma

Chirurgia ◽

10.23736/s0394-9508.18.04824-6 ◽

2019 ◽

Vol 32 (3) ◽

Author(s):

Emanuele Santoro ◽

Paolo Visca ◽

Roberto Santoro ◽

Pietro Mancini ◽

Eugenio Santoro

Keyword(s):

Invasive Carcinoma ◽

Long Survival ◽

Disease Free

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ERG positive PIN-like lesions without atypia: a retrograde colonisation of glands by invasive carcinoma instead of a preneoplasic lesion?

10.26226/morressier.5b47098a6f4cb30010951892 ◽

2018 ◽

Author(s):

Alexandre Serantes Combo ◽

JOSÉ A. ORTIZ REY

Keyword(s):

Invasive Carcinoma

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Dysplasia, Carcinoma in Situ, and Invasive Carcinoma of the Cervix Uteri in Previously Screened Women

Scandinavian Journal of Clinical and Laboratory Investigation ◽

10.3109/00365516809168213 ◽

1968 ◽

Vol 21 ◽

pp. 173-180 ◽

Cited By ~ 1

Author(s):

Kari Høeg ◽

Vivi Roger

Keyword(s):

Carcinoma In Situ ◽

Invasive Carcinoma ◽

Cervix Uteri

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Pre-Operative Imaging and Pathological Diagnosis of Localized High-Grade Pancreatic Intra-Epithelial Neoplasia without Invasive Carcinoma

Cancers ◽

10.3390/cancers13050945 ◽

2021 ◽

Vol 13 (5) ◽

pp. 945

Author(s):

Ryota Sagami ◽

Kentaro Yamao ◽

Jun Nakahodo ◽

Ryuki Minami ◽

Masakatsu Tsurusaki ◽

...

Keyword(s):

Pancreatic Duct ◽

Invasive Carcinoma ◽

Current Knowledge ◽

Precancerous Lesions ◽

Ductal Adenocarcinoma ◽

Pancreatic Ducts ◽

High Grade ◽

Cytologic Examination ◽

Imaging Characteristics ◽

Retention Cysts

Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions, such as pancreatic intra-epithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN). The prognosis of high-grade precancerous lesions, including high-grade PanIN and high-grade IPMN, without invasive carcinoma is good, despite the overall poor prognosis of PDAC. High-grade PanIN, as a lesion preceding invasive PDAC, is therefore a primary target for intervention. However, detection of localized high-grade PanIN is difficult when using standard radiological approaches. Therefore, most studies of high-grade PanIN have been conducted using specimens that harbor invasive PDAC. Recently, imaging characteristics of high-grade PanIN have been revealed. Obstruction of the pancreatic duct due to high-grade PanIN may induce a loss of acinar cells replaced by fibrosis and lobular parenchymal atrophy. These changes and additional inflammation around the branch pancreatic ducts (BPDs) result in main pancreatic duct (MPD) stenosis, dilation, retention cysts (BPD dilation), focal pancreatic parenchymal atrophy, and/or hypoechoic changes around the MPD. These indirect imaging findings have become important clues for localized, high-grade PanIN detection. To obtain pre-operative histopathological confirmation of suspected cases, serial pancreatic-juice aspiration cytologic examination is effective. In this review, we outline current knowledge on imaging characteristics of high-grade PanIN.

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SEMA6D Expression and Patient Survival in Breast Invasive Carcinoma

International Journal of Breast Cancer ◽

10.1155/2015/539721 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 13

Author(s):

Dongquan Chen ◽

Yufeng Li ◽

Lizhong Wang ◽

Kai Jiao

Keyword(s):

Breast Cancer ◽

Expression Profile ◽

Heart Development ◽

Invasive Carcinoma ◽

Patient Survival ◽

The Cancer Genome Atlas ◽

Breast Cancer Patients ◽

Genomic Expression ◽

Cancer Genome Atlas ◽

Public Datasets

Breast cancer (BC) is the second most common cancer diagnosed in American women and is also the second leading cause of cancer death in women. Research has focused heavily on BC metastasis. Multiple signaling pathways have been implicated in regulating BC metastasis. Our knowledge of regulation of BC metastasis is, however, far from complete. Identification of new factors during metastasis is an essential step towards future therapy. Our labs have focused on Semaphorin 6D (SEMA6D), which was implicated in immune responses, heart development, and neurogenesis. It will be interesting to know SEMA6D-related genomic expression profile and its implications in clinical outcome. In this study, we examined the public datasets of breast invasive carcinoma from The Cancer Genome Atlas (TCGA). We analyzed the expression of SEMA6D along with its related genes, their functions, pathways, and potential as copredictors for BC patients’ survival. We found 6-gene expression profile that can be used as such predictors. Our study provides evidences for the first time that breast invasive carcinoma may contain a subtype based on SEMA6D expression. The expression of SEMA6D gene may play an important role in promoting patient survival, especially among triple negative breast cancer patients.

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Nodular Elastosis of the Pancreas

Case Reports in Pathology ◽

10.1155/2015/521959 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3

Author(s):

Whitney Wedel ◽

Geoffrey Talmon ◽

Aaron Sasson

Keyword(s):

Gastrointestinal Tract ◽

Vascular Injury ◽

Colonic Polyp ◽

Similar Morphology ◽

Benign Process ◽

Inflammatory Changes

Elastofibromatous change is a benign process that has been increasingly recognized in the tubular gastrointestinal tract. These changes can present as a colonic polyp or be seen in conjunction with inflammatory changes. Similar lesions have been noted in the liver, apparently associated with vascular injury. We describe a case in which multiple circumscribed nodules of elastofibromatous change within the pancreas had a similar morphology to nodular elastosis of the liver. To our knowledge, this is the first description of such a finding occurring within the pancreas.

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