scholarly journals Age related increase in cav-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S105
Author(s):  
Tae-Young Ha ◽  
Yu Ree Choi ◽  
Hye Rin Noh ◽  
Ka Young Kim ◽  
Sang Myun Park
Keyword(s):  
Age Related ◽  
Cell Transmission ◽  
Related Increase

scholarly journals Age-Related Increase in Caveolin-1 Expression Facilitates Cell-to-Cell Transmission of α-Synuclein in Neurons

2021 ◽  
Author(s):  
Tae-Young Ha ◽  
Yu Ree Choi ◽  
Hye Rin Noh ◽  
Seon-Heui Cha ◽  
Jae-Bong Kim ◽  
...  
Keyword(s):  
Risk Factor ◽  
Inclusion Bodies ◽  
Aging Process ◽  
Caveolin 1 ◽  
Age Related ◽  
Cell Transmission ◽  
Tyrosine 14 ◽  
The Relationship ◽  
The Brain ◽  
Related Increase

Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging process. Recent evidence indicates that prion-like propagation of misfolded α-synuclein (α-syn) released from neurons to neighboring neurons plays an important role in PD progression. In the present study, we demonstrated that cav-1 expression in the brain increased with age, and considerably increased in the brain of A53T α-syn transgenic mice. Cav-1 overexpression facilitated the uptake of α-syn into neurons and formation of additional Lewy body-like inclusion bodies, phosphorylation of cav-1 at tyrosine 14 was found to be crucial for this process. This study demonstrates the relationship between age and α-syn spread and will facilitate our understanding of the molecular mechanism of the cell-to-cell transmission of α-syn.

scholarly journals Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Tae-Young Ha ◽  
Yu Ree Choi ◽  
Hye Rin Noh ◽  
Seon-Heui Cha ◽  
Jae-Bong Kim ◽  
...  
Keyword(s):  
Risk Factor ◽  
Inclusion Bodies ◽  
Aging Process ◽  
Caveolin 1 ◽  
Age Related ◽  
Cell Transmission ◽  
Tyrosine 14 ◽  
The Relationship ◽  
The Brain ◽  
Related Increase

AbstractParkinson's disease (PD) is the second most prevalent neurodegenerative disease, with aging being considered the greatest risk factor for developing PD. Caveolin-1 (Cav-1) is known to participate in the aging process. Recent evidence indicates that prion-like propagation of misfolded α-synuclein (α-syn) released from neurons to neighboring neurons plays an important role in PD progression. In the present study, we demonstrated that cav-1 expression in the brain increased with age, and considerably increased in the brain of A53T α-syn transgenic mice. Cav-1 overexpression facilitated the uptake of α-syn into neurons and formation of additional Lewy body-like inclusion bodies, phosphorylation of cav-1 at tyrosine 14 was found to be crucial for this process. This study demonstrates the relationship between age and α-syn spread and will facilitate our understanding of the molecular mechanism of the cell-to-cell transmission of α-syn.

Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse

1990 ◽  
Vol 237 (3-4) ◽  
pp. 131-146 ◽  
Author(s):  
Karen Swisshelm ◽  
Christine M. Disteche ◽  
Joanne Thorvaldsen ◽  
Andrew Nelson ◽  
Darrell Salk
Keyword(s):  
Gene Clusters ◽  
Ribosomal Genes ◽  
Rrna Gene ◽  
Age Related ◽  
Related Increase

Age-related increase of CD45RO+ lymphocytes in physically active adults

1993 ◽  
Vol 23 (10) ◽  
pp. 2704-2706 ◽  
Author(s):  
Holger Gabriel ◽  
Barbara Schmitt ◽  
Wilfried Kindermann
Keyword(s):  
Physically Active ◽  
Age Related ◽  
Active Adults ◽  
Related Increase

Mashkov’s diamond as an indicator of posture in boys of the second childhood period at the initial stage of martial arts

2021 ◽  
Vol 22 (1) ◽  
pp. 61-65
Author(s):  
N. Ya. Prokopiev ◽  
◽  
E. T. Kolunin ◽  
D. S. Reсhapov ◽  
O. V. Baranhin ◽  
...  
Keyword(s):  
Secondary School ◽  
Martial Arts ◽  
Spinal Column ◽  
Russian Patent ◽  
Cervical Lordosis ◽  
Training Process ◽  
Lumbar Level ◽  
Age Related ◽  
Initial Stage ◽  
Related Increase

Aim: boys of the second childhood period at the initial stage of martial arts to study the age characteristics of Mashkov’s diamond and the depth of the vertebral pole lordosis at the cervical and lumbar level as indicators of posture. Material and methods. 28 boys of the second childhood period (8-12 years) engaged in martial arts on the basis of JUSS No. 3 by V. G. Khromin of Tyumen were examined. The evaluation of Mashkov’s diamond was carried out according to the conventional method. The depth of the vertebral column lordosis at the cervical and lumbar level as an indicator of posture was assessed with the help of the device proposed by us (Russian Patent for useful model No. 30253). Results. The age-old size of Mashkov’s diamond sides increased as the boys grew up and did not indicate scoliotic spinal column disease. The “jumps” of its increase in the period of 11-12 years have been revealed. The age-related increase in the depth of lordosis at the cervical and lumbar level of the spinal column, more pronounced in the lumbar department, has been noted. Conclusion. According to Мashkov’s diamond, boys of the second childhood period have no abnormalities on the part of the spinal column. The depth of the vertebral pole lordosis at the lumbar level exceeds the depth of the cervical lordosis, which should be taken into account when dosing physical activity in physical education classes in the secondary school and during the training process in JUSH.

scholarly journals Evaluation of apoptotic cell death in normal and chondrodystrophic canine intervertebral discs

2012 ◽  
Vol 2 (1) ◽  
pp. 6 ◽  
Author(s):  
Marie Klauser ◽  
Franck Forterre ◽  
Marcus Doherr ◽  
Andreas Zurbriggen ◽  
David Spreng ◽  
...  
Keyword(s):  
Nucleus Pulposus ◽  
Disc Degeneration ◽  
Annulus Fibrosus ◽  
Caspase 3 ◽  
Apoptotic Cell ◽  
Intervertebral Discs ◽  
Discogenic Pain ◽  
Age Related ◽  
Chondroid Metaplasia ◽  
Related Increase

Disc degeneration occurs commonly in dogs. A variety of factors is thought to contribute an inappropriate disc matrix that isolate cells in the disc and lead to apoptosis. Disc herniation with radiculopathy and discogenic pain are the results of the degenerative process. The objective of this prospective study was to determine the extent of apoptosis in intact and herniated intervertebral discs of chondrodystrophic dogs and non-chondrodystrophic dogs. In addition, the nucleus pulposus (NP) was histologically compared between non-chondrodystrophic and chondrodystrophic dogs. Thoracolumbar intervertebral discs and parts of the extruded nucleus pulposus were harvested from 45 dogs. Samples were subsequently stained with haematoxylin-eosin and processed to detect cleaved caspase-3 and poly(ADP-ribose) polymerase. A significant greater degree of apoptosis was observed in herniated NPs of chondrodystrophic dogs compared to non- chondrodystrophic dogs with poly (ADP-ribose) polymerase and cleaved caspase- 3 detection. Within the group of chondrodystrophic dogs, dogs with an intact disc and younger than 6 years showed a significant lower incidence of apoptosis in the NP compared to the herniated NP of chondrodystrophic dogs. The extent of apoptosis in the annulus fibrosus was not different between the intact disc from chondrodystrophic and non- chondrodystrophic dogs. An age-related increase of apoptotic cells in NP and annulus fibrosus was found in the intact non-herniated intervertebral discs. Histologically, absence of notochordal cells and occurrence of chondroid metaplasia were observed in the nucleus pulposus of chondrodystrophic dogs. As a result, we found that apoptosis plays a role in disc degeneration in chondrodystrophic dogs.

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