The single-phase heat transfer enhancement techniques are well established for conventional channels and compact heat exchangers. The major techniques include flow transition, breakup of boundary layer, entrance region, vibration, electric fields, swirl flow, secondary flow and mixers. In the present paper, the applicability of these techniques for single-phase flows in microchannels and minichannels is evaluated. The microchannel and minichannel single-phase heat transfer enhancement devices will extend the applicability of single-phase cooling for critical applications, such as chip cooling, before more aggressive cooling techniques, such as flow boiling, are considered.