Risk factors and clinical outcomes of acute coronary syndrome in men: A retrospective study

BackgroundCardiovascular disease is the leading cause of death worldwide accounting for 17.3 million deaths per year, a number that is estimated to grow to more than 23.6 million by 2030. Coronary artery disease (CAD) is the most common form of cardiovascular diseases and remains the number one cause of death in the United States, killing more than 375,000 Americans every year. Acute coronary syndrome (ACS) is a manifestation of CAD, which is life threatening and an emergency situation.ObjectiveTo provide an overview and an awareness of ACS based on risk factors, early clinical assessment tools, and to improving clinical outcomes.MethodsFor registered nurses (RNs) in any clinical setting, this overview will educate and inform nurses how they can approach patient care in an urgent and timely manner.ResultsAdvances in diagnostic cardiac biomarkers, risk assessment tools, medical management, and invasive strategies have allowed for earlier and more accurate diagnosis and treatment of ACS, thereby improving clinical outcomes.ConclusionsCompetence in early recognition of the major differences in clinical presentation of ACS will enable prompt diagnosis and initiation of proven therapies.Implications for Nursing PracticeAs the prevalence for ACS continues to rise, RNs in all clinical settings should make a concerted effort to identify and mitigate risk factors early as well as to recognize, diagnose, and respond to ACS events in a timely manner.

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Prevalence, Presenting Complaints, Risk Factors and Comorbidity of Acute Coronary Syndrome at Orotta National Referral Hospital Intensive Care Unit Eritrea: Retrospective Study

Science Journal of Public Health ◽

10.11648/j.sjph.20170506.18 ◽

2017 ◽

Vol 5 (6) ◽

pp. 457

Author(s):

Elias Teages Adgoy

Keyword(s):

Risk Factors ◽

Intensive Care Unit ◽

Acute Coronary Syndrome ◽

Intensive Care ◽

Retrospective Study ◽

Referral Hospital ◽

Coronary Syndrome ◽

Hospital Intensive Care Unit ◽

National Referral Hospital

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P4590Temporal trends of the characteristics, management, and clinical outcomes of patients with acute coronary syndrome and multi-vessel disease - the ACSIS registry

European Heart Journal ◽

10.1093/eurheartj/ehz745.0975 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

A Shiyovich ◽

N Shlomo ◽

Z Iakobishvili ◽

R Kornowski ◽

A Eisen

Keyword(s):

Risk Factors ◽

Acute Coronary Syndrome ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Clinical Outcomes ◽

Statistical Significance ◽

Temporal Trends ◽

Coronary Intervention ◽

Coronary Syndrome ◽

Vessel Disease

Abstract Introduction Multi-vessel coronary artery disease (MVD) is common among patients with acute coronary syndrome (ACS) and is associated with worse outcomes compared with single-vessel disease. Multiple studies focused particularly on patients with ACS and MVD and their results were incorporated into guidelines' recommendations. Objectives To examine temporal trends in clinical characteristics, treatment and outcomes of patients presenting with ACS and MVD. Methods Time- dependent analysis of patients enrolled in the biennial ACS Israeli Surveys (ACSIS) between 2000 and 2016 according to three time periods: early (2004–2006; n=2,111), mid (2008–2010; n=2,049), and late (2013–2016; n=2,010). MVD was defined as >50% stenosis in ≥2 separate major coronary territories at the index ACS. Clinical outcomes were 30-day MACE (death, unstable angina, myocardial infarction, stroke, stent thrombosis, urgent revascularization) and 30-days and 1-year mortality. Results Overall 6,170/15,000 patients (41.1%) had MVD (age 64.5±12.1, males 80%). Patients admitted in the later periods were older with a higher prevalence of cardiovascular risk factors and their treatment (i.e. statins, and hypoglycemic drugs) prior to admission. The rate of CABG has decreased and of MV percutaneous coronary intervention and guideline recommended medical treatment has increased with time. At 30 days, the rates of mortality, MACE and re-infarction have decreased (Figure). A trend of reduction in 1-year mortality was observed with time, yet it did not reach statistical significance (early=9.3%, mid=7.8%, late=7.7%, P=0.13). A multivariate adjusted analysis demonstrated that the mid and late periods were associated with significantly reduced risk for 30-day MACE (OR=0.65 [0.54–0.77] and 0.54 [0.45–0.65], respectively). Figure 1. Temporal trends in 30-day outcomes of patients with ACS and MVD Conclusions During the last decade, the burden of cardiovascular risk factors among ACS patients with MVD has increased, more extensive invasive and medical treatments were provided and significant improvements in 30-day outcomes were observed. Acknowledgement/Funding None

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