Impact of area under the concentration–time curve to minimum inhibitory concentration ratio on vancomycin treatment outcomes in methicillin-resistant Staphylococcus aureus bacteraemia

2015 ◽  
Vol 46 (6) ◽  
pp. 689-695 ◽  
Author(s):  
Kyoung-Ho Song ◽  
Hong Bin Kim ◽  
Hyung-sook Kim ◽  
Myung Jin Lee ◽  
Younghee Jung ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Minimum Inhibitory Concentration ◽  
Treatment Outcomes ◽  
Concentration Ratio ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Time Curve ◽  
Concentration Time ◽  
Minimum Inhibitory Concentration Ratio ◽  
Vancomycin Treatment

scholarly journals Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2758 ◽  
Author(s):  
Rawan Alnufaie ◽  
Hansa Raj KC ◽  
Nickolas Alsup ◽  
Jedidiah Whitt ◽  
Steven Andrew Chambers ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Minimum Inhibitory Concentration ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Fatality Rate ◽  
Pyrazole Derivatives ◽  
Methicillin Resistant ◽  
Antimicrobial Studies ◽  
Mrsa Strains

In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of the most menacing pathogens of humans and this bacterium is bypassing HIV in terms of fatality rate.

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