Oral administration of chitin and chitosan prevents peanut-induced anaphylaxis in a murine food allergy model

2013 ◽  
Vol 61 ◽  
pp. 164-168 ◽  
Author(s):  
Min-Jung Bae ◽  
Hee Soon Shin ◽  
En-Kyoung Kim ◽  
Jaeheung Kim ◽  
Dong-Hwa Shon
Keyword(s):  
Food Allergy ◽  
Oral Administration ◽  
Chitin And Chitosan

Oral Administration of Bacterial Lysates Attenuates Experimental Food Allergy

2011 ◽  
Vol 156 (2) ◽  
pp. 196-204 ◽  
Author(s):  
Birgit Ahrens ◽  
David Quarcoo ◽  
Sabine Buhner ◽  
Paolo M. Matricardi ◽  
Eckard Hamelmann
Keyword(s):  
Food Allergy ◽  
Oral Administration ◽  
Bacterial Lysates

Probiotics Have a Different Immunomodulatory Potential in vitro versus ex vivo upon Oral Administration in Children with Food Allergy

2007 ◽  
Vol 143 (3) ◽  
pp. 237-244 ◽  
Author(s):  
A.E. Flinterman ◽  
E.F. Knol ◽  
A.G. van Ieperen-van Dijk ◽  
H.M. Timmerman ◽  
A.C. Knulst ◽  
...  
Keyword(s):  
Food Allergy ◽  
Oral Administration ◽  
Ex Vivo ◽  
Immunomodulatory Potential

scholarly journals Comparison of intestinal APC subsets from homeostatic and immunostimulatory environments

2021 ◽  
Author(s):  
◽  
Kerry Hilligan
Keyword(s):  
T Cells ◽  
Food Allergy ◽  
Immune Responses ◽  
Oral Administration ◽  
Mesenteric Lymph Nodes ◽  
Adaptive Immune Responses ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Adaptive Immune ◽  
Inflammatory Bowel

<p>Antigen presenting cells (APC) including dendritic cells (DC) play a key role in the initiation and direction of adaptive immune responses. Acting as sentinels in the tissue, DC sample antigen and traffic to the local lymph node where they present antigen to naïve T cells. The signals DC provide to naïve T cells determines the functional fate of the T cell and therefore, the type of immune response generated. At mucosal sites, such as the intestine, immune responses need to be carefully regulated due to the high antigenic load. For this reason, intestinal immune cells are highly specialised to prevent immune activation to innocuous antigens while still holding the capacity to induce potent responses to pathogenic microbes and helminths. Oral administration of antigen is associated with tolerance and the generation of FoxP3+ regulatory T cells (Tregs). Specialised lamina propria (LP) resident APC are required for the initiation of Treg differentiation in the mesenteric lymph nodes (MLN) through production of chemical mediators such as retinoic acid (RA). Ablation of these populations or restricted trafficking prevents the development of Tregs in mouse models thus supporting the essential role of APC in maintaining intestinal homeostasis. During infection, APC promote the induction of adaptive immune responses which neutralise threats. However, the APC subsets involved in this are not well defined. Pathologies such as food allergy and inflammatory bowel disease are thought to arise due to the development of aberrant immune responses. Food allergy can be modelled in mice using the mucosal adjuvant cholera toxin (CT) which has been shown to drive immunity to co-delivered antigens and is associated with the generation of IL-4 producing T helper 2 cells. Understanding the APC subsets involved in the initiation of intestinal immune responses could help in the development of targeted therapies for inflammatory bowel conditions. In this thesis, I show that oral administration of CT is followed by the appearance of a novel phenotype of DC in the intestinal LP and MLN. These DC differ functionally from DC at steady-state and may contribute to the generation of IL-4 producing T cells observed in the LP, MLN and spleen following oral administration of CT.</p>

Effect of Saccharomyces cerevisiae UFMG A-905 in a murine model of food allergy

2020 ◽  
Vol 11 (3) ◽  
pp. 255-268
Author(s):  
V.C. Miranda ◽  
S.S. Santos ◽  
H.C. Assis ◽  
A.M.C. Faria ◽  
M.F. Quintanilha ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Food Allergy ◽  
Oral Administration ◽  
Tissue Injury ◽  
Pathological Condition ◽  
In Vivo Model ◽  
Interleukin 17 ◽  
Yeast Culture ◽  
Probiotic Effect

Food allergy is triggered when there is an abnormal activation of the immune system by food allergens. Currently, there is no curative therapy for this pathological condition. Due to the immunomodulatory properties of probiotics they are potential candidates as therapeutic tools for food allergy. Therefore, the aim of this study was to evaluate the probiotic effect of Saccharomyces cerevisiae UFMG A-905 (905) in an in vivo model of food allergy. Probiotic effect was assessed by clinical, histological, immunological and microbiological parameters analysis. Furthermore, we also evaluated if 905 after inactivation has an effect, as well as if such an effect is dose dependent. Our results showed that oral administration of only viable 905 promotes a significant attenuation of tissue injury and myeloperoxidase (MPO) activity levels. Moreover, the treatment reduced interleukin 17 levels, and administration of the supernatant from the yeast culture also promoted a significant decrease in MPO levels. However, considering the systemic parameters, immunoglobulin (Ig)E and IgG anti-ovalbumin, which are essentials for triggering the allergic process, there was no effect, suggesting that the yeast promotes a local but not a systemic effect in the model evaluated. In addition, we found that only high doses of viable 905 were able to attenuate the signs of inflammation. In conclusion, oral administration of 905 led to a local effect that depends on the viability of the yeast.

scholarly journals Comparison of intestinal APC subsets from homeostatic and immunostimulatory environments

2021 ◽  
Author(s):  
◽  
Kerry Hilligan
Keyword(s):  
T Cells ◽  
Food Allergy ◽  
Immune Responses ◽  
Oral Administration ◽  
Mesenteric Lymph Nodes ◽  
Adaptive Immune Responses ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Adaptive Immune ◽  
Inflammatory Bowel

<p>Antigen presenting cells (APC) including dendritic cells (DC) play a key role in the initiation and direction of adaptive immune responses. Acting as sentinels in the tissue, DC sample antigen and traffic to the local lymph node where they present antigen to naïve T cells. The signals DC provide to naïve T cells determines the functional fate of the T cell and therefore, the type of immune response generated. At mucosal sites, such as the intestine, immune responses need to be carefully regulated due to the high antigenic load. For this reason, intestinal immune cells are highly specialised to prevent immune activation to innocuous antigens while still holding the capacity to induce potent responses to pathogenic microbes and helminths. Oral administration of antigen is associated with tolerance and the generation of FoxP3+ regulatory T cells (Tregs). Specialised lamina propria (LP) resident APC are required for the initiation of Treg differentiation in the mesenteric lymph nodes (MLN) through production of chemical mediators such as retinoic acid (RA). Ablation of these populations or restricted trafficking prevents the development of Tregs in mouse models thus supporting the essential role of APC in maintaining intestinal homeostasis. During infection, APC promote the induction of adaptive immune responses which neutralise threats. However, the APC subsets involved in this are not well defined. Pathologies such as food allergy and inflammatory bowel disease are thought to arise due to the development of aberrant immune responses. Food allergy can be modelled in mice using the mucosal adjuvant cholera toxin (CT) which has been shown to drive immunity to co-delivered antigens and is associated with the generation of IL-4 producing T helper 2 cells. Understanding the APC subsets involved in the initiation of intestinal immune responses could help in the development of targeted therapies for inflammatory bowel conditions. In this thesis, I show that oral administration of CT is followed by the appearance of a novel phenotype of DC in the intestinal LP and MLN. These DC differ functionally from DC at steady-state and may contribute to the generation of IL-4 producing T cells observed in the LP, MLN and spleen following oral administration of CT.</p>

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