Protective effect of chemically modified SOD on lipid peroxidation and antioxidant status in diabetic rats

2015 ◽  
Vol 72 ◽  
pp. 79-87 ◽  
Author(s):  
Banu Mansuroğlu ◽  
Serap Derman ◽  
Aylin Yaba ◽  
Kadriye Kızılbey
Keyword(s):  
Lipid Peroxidation ◽  
Protective Effect ◽  
Antioxidant Status ◽  
Diabetic Rats ◽  
Chemically Modified

Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats

2001 ◽  
Vol 31 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Huseyin Vural ◽  
Tevfik Sabuncu ◽  
S. Oktay Arslan ◽  
Nurten Aksoy
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Status ◽  
Diabetic Rats

Modulatory Effect of Gymnema montanum Leaf Extract on Brain Antioxidant Status and Lipid Peroxidation in Diabetic Rats

2004 ◽  
Vol 7 (3) ◽  
pp. 366-371
Author(s):  
Kunga Mohan Ramkumar ◽  
Muniappan Latha ◽  
Subramaniam Venkateswaran ◽  
Leelavinothan Pari ◽  
Rajendran Ananthan ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Status ◽  
Leaf Extract ◽  
Diabetic Rats

scholarly journals Anti Hyperglycemic, Anti Oxidant, Anti Hyperlipidemic & Nephroprotective Effect of Stevioside in Diabetic Rats

2017 ◽  
Vol 8 (4) ◽  
Author(s):  
Ambily Scaria ◽  
Jagadhish V Kamath ◽  
Manodeep Chakraborty
Keyword(s):  
Lipid Peroxidation ◽  
Diabetic Nephropathy ◽  
Protective Effect ◽  
Total Cholesterol ◽  
Serum Levels ◽  
Diabetic Rats ◽  
High Density Lipoproteins ◽  
Anti Oxidant ◽  
Nephroprotective Effect

Objective: The present study aimed to evaluate in vivo the antihyperglycemic, anti oxidant,antihyperlipidemic and nephroprotective effects of Stevioside against Alloxan induced diabetic nephropathy in rats. Materials and Methods: In this model diabetes was induced using Alloxan (125 mg/kg, i.p) and the prophylactic treatment was started 48 hours after Alloxan injection for 28 days. The protective effect of the treatment with standard (Glibenclamide 0.5mg/kg, p.o) and Stevioside (250 mg/kg. p.o) were analyzed by estimating the serum levels of glucose, urea, creatinine, albumin, total protein, total cholesterol (TCH), triglycerides (TG), high density lipoproteins (HDL) and antioxidants like SOD, catalase and lipid peroxidation. Key Findings: This study demonstrates that Stevioside improved hyperglycemia and maintained antioxidant status and reduced total cholesterol, TG, urea, creatinine and albumin and lipid peroxidation levels when compared to toxic control. The protective effect of Stevioside against Alloxan induced diabetic nephropathy in rats was also supported by histopathologic findings.The results of the present study are encouraging for its potential use to delay the onset and progression of diabetic renal complications. However, the translation of therapeutic efficacy in humans requires further studies.

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