Abstract
Chronic exposure to arsenic causes the abnormal development of embryo during pregnancy. So the study is designed to investigate the antioxidant and tissue protective properties of Moringa oleifera extracts against sodium arsenate induced embryo toxicity. Moringa oleifera extracts (leaf and flower) were prepared using soxhelt apparatus. Fourty four pregnant females were equally divided in 11 experimental groups (A-K). Group A was of control while B and C were sodium arsenate treated groups as group A (0.00), B (6.00, 0.00), C (12.00, 0.00). Group D to G were of sodium arsenate + Moringa oleifera flower extract treated groups with doses D (6.00, 150.00), E (6.00, 300.00), F (12.00, 150.00), G (12.00, 300.00) and groups H to K were sodium arsenate + Moringa oleifera leaf extracts treated groups H (6.00, 150.00), I (6.00, 300.00), J (12.00, 150.00) and K (12.00, 300.00) mg/kg B.W. Significant (p < 0.05) increased in MDA (malanodialdehyde) values 41.75 ± 3.40 and decreased GSH (glutathione) values 7.75 ± 0.95 in sodium arsenate treated groups were observed as compared to control 25 ± 0.81(MDA) and 18.5 ± 0.57 (GSH). Moringa oleifera extracts treated groups especially Moringa oleifera leaf extract at dose of 300mg/kg B.W normalized the MDA (25.25 ± 0.50) and GSH (18.25 ± 1.70) values. Sodium arsenate induced the histopathologiacl changes like malformed heart, meningocoel, spina bifida, anopathalmia, cavitization, degenerated kidney and intestine. Whereas Moringa oleifera leaf extract as ameliorant minimized these histopathological abnormalities. It is concluded that Moringa oleifera leaf extract is mixture of biomolecules as it has antioxidant activity, so can be used as ameliorant against sodium arsenate.
Corrigendum to “Protective role of Moringa oleifera leaf extract on cardiac antioxidant status and lipid peroxidation in streptozotocin induced diabetic rats” [Heliyon 5, (12), (December 2019), e02935]
