Hypericum perforatum incorporated chitosan films as potential bioactive wound dressing material

Natural polymers such as chitosan and Aloe vera are widely used in novel wound dressings due to their biocompatibility and biodegradability. A problem associated with these polymers is their poor mechanical behavior. Efforts have been made to improve the mechanical properties by mixing synthetic polymers such as PVA, but the role of chitosan and Aloe vera in the final dressing is dimmed. The techniques are also time-consuming and costly and there is still a need for an acceptable and affordable wound dressing which can be made through easily accessible techniques. A new but very simple method is introduced in this work for incorporating PVA nanofibers with Aloe vera-containing chitosan films. Using this method the levels of Aloe vera and chitosan in the system can be optimized at higher scales while benefiting from PVA best mechanical properties as a composite layer. Higher amounts of Aloe vera and chitosan in the system lead to lower product costs and more biocompability. The biological properties of films were examined through cell cytotoxicity and antibacterial tests and compared with Atomic force microscopy results. Physical and mechanical properties of films containing PVA nanofibers were characterized by water vapor permeability, swelling ratio, and tensile tests. The morphology of fibers before and after applying on the films was also observed by scanning electron microscopy. According to the results, this combination of natural and synthetic polymers has led to an affordable, biocompatible, and flexible film for wound dressing applications.

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A Study of Chitosan Films as a Feasible Material for Wound Dressing

IRC-SET 2018 ◽

10.1007/978-981-32-9828-6_15 ◽

2019 ◽

pp. 173-182

Author(s):

Geraldine Foo Yawen

Keyword(s):

Wound Dressing ◽

Chitosan Films

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Development of Hypericum perforatum oil incorporated antimicrobial and antioxidant chitosan cryogel as a wound dressing material

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2020.08.056 ◽

2020 ◽

Vol 161 ◽

pp. 1581-1590

Author(s):

Nimet Bölgen ◽

Didem Demir ◽

M. Serkan Yalçın ◽

Sadin Özdemir

Keyword(s):

Wound Dressing ◽

Hypericum Perforatum

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Evaluation of poly ε-caprolactone electrospun nanofibers loaded with Hypericum perforatum extract as a wound dressing

Research on Chemical Intermediates ◽

10.1007/s11164-016-2623-7 ◽

2016 ◽

Vol 43 (1) ◽

pp. 297-320 ◽

Cited By ~ 15

Author(s):

Faegheh Pourhojat ◽

Mahmoodreza Sohrabi ◽

Shahab Shariati ◽

Hamid Mahdavi ◽

Leila Asadpour

Keyword(s):

Wound Dressing ◽

Hypericum Perforatum ◽

Electrospun Nanofibers

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Development of bioactive compounds-loaded chitosan films by using a QbD approach – A novel and potential wound dressing material

Reactive and Functional Polymers ◽

10.1016/j.reactfunctpolym.2019.02.013 ◽

2019 ◽

Vol 138 ◽

pp. 46-54 ◽

Cited By ~ 9

Author(s):

Liora Colobatiu ◽

Alexandru Gavan ◽

Andrei Mocan ◽

Catalina Bogdan ◽

Simona Mirel ◽

...

Keyword(s):

Bioactive Compounds ◽

Wound Dressing ◽

Chitosan Films

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Hypericum perforatum and Azadirachta indica (Neem) oil in the management of chronic leg ulcers: An uncontrolled retrospective observational case review

Italian Journal of Wound Care ◽

10.4081/ijwc.2021.79 ◽

2021 ◽

Vol 5 (3) ◽

Author(s):

Lisa Turk ◽

Tobias Thuile ◽

Valentina De Marzi ◽

Giovanni Antonacci ◽

Mario Puviani ◽

...

Keyword(s):

Azadirachta Indica ◽

Wound Dressing ◽

Hypericum Perforatum ◽

Local Treatment ◽

Wound Management ◽

High Morbidity ◽

Leg Ulcers ◽

Case Review ◽

Neem Oil ◽

Chronic Leg Ulcers

Chronic nonhealing leg ulcers are debilitating with high morbidity in a vulnerable patient population and pose a frequent clinical and socioeconomic problem. Numerous local treatment options exist, but clinical trials are rare and wound management still represents a big challenge. Recently a wound dressing based on the natural remedies Hypericum perforatum and Neem oil has been proposed for chronic wound management, but trials on nonhealing leg ulcers are missing. Uncontrolled retrospective observational case review on all patients under our supervision with chronic leg ulcers who underwent treatment with a plant-derived wound dressing based on Hypericum perforatum and Azadirachta indica (Neem) oil. It could be retrieved in a total 16 cases (11 female) with a median age of 71 years. All ulcers (7 ulcers on the leg and 9 ulcers on the feed) showed a complete healing after a median healing time of 82 days (Mean 85, range 14-180 days). No side effects occurred, medication was painless or even reduced pain. Wound dressings based on Hypericum perforatum and Neem oil are well tolerated and could be a potential additional simple treatment option in the management of non-healing leg ulcers. Prospective controlled trials are needed to confirm these observations.

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Chitosan films containing mesoporous SBA-15 supported silver nanoparticles for wound dressing

Journal of Materials Chemistry B ◽

10.1039/c4tb00927d ◽

2014 ◽

Vol 2 (36) ◽

pp. 6054 ◽

Cited By ~ 54

Author(s):

Valeria Ambrogi ◽

Anna Donnadio ◽

Donatella Pietrella ◽

Loredana Latterini ◽

Federica Alunni Proietti ◽

...

Keyword(s):

Silver Nanoparticles ◽

Wound Dressing ◽

Chitosan Films

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Physicochemical Properties and Cell Viability of Shrimp Chitosan Films as Affected by Film Casting Solvents. I-Potential Use as Wound Dressing

Materials ◽

10.3390/ma13215005 ◽

2020 ◽

Vol 13 (21) ◽

pp. 5005

Author(s):

Hugo Yves C. Eulálio ◽

Mariana Vieira ◽

Thiago B. Fideles ◽

Helena Tomás ◽

Suédina M. L. Silva ◽

...

Keyword(s):

Water Vapor ◽

Physicochemical Properties ◽

Wound Dressing ◽

Film Casting ◽

Acid Type ◽

Shrimp Shell ◽

Shell Waste ◽

Shrimp Shell Waste ◽

Film Preparation ◽

Chitosan Films

Chitosan solubility in aqueous organic acids has been widely investigated. However, most of the previous works have been done with plasticized chitosan films and using acetic acid as the film casting solvent. In addition, the properties of these films varied among studies, since they are influenced by different factors such as the chitin source used to produce chitosan, the processing variables involved in the conversion of chitin into chitosan, chitosan properties, types of acids used to dissolve chitosan, types and amounts of plasticizers and the film preparation method. Therefore, this work aimed to prepare chitosan films by the solvent casting method, using chitosan derived from Litopenaeus vannamei shrimp shell waste, and five different organic acids (acetic, lactic, maleic, tartaric, and citric acids) without plasticizer, in order to evaluate the effect of organic acid type and chitosan source on physicochemical properties, degradation and cytotoxicity of these chitosan films. The goal was to select the best suited casting solvent to develop wound dressing from shrimp chitosan films. Shrimp chitosan films were analyzed in terms of their qualitative assessment, thickness, water vapor permeability (WVP), water vapor transmission rate (WVTR), wettability, tensile properties, degradation in phosphate buffered saline (PBS) and cytotoxicity towards human fibroblasts using the resazurin reduction method. Regardless of the acid type employed in film preparation, all films were transparent and slightly yellowish, presented homogeneous surfaces, and the thickness was compatible with the epidermis thickness. However, only the ones prepared with maleic acid presented adequate characteristics of WVP, WVTR, wettability, degradability, cytotoxicity and good tensile properties for future application as a wound dressing material. The findings of this study contributed not only to select the best suited casting solvent to develop chitosan films for wound dressing but also to normalize a solubilization protocol for chitosan, derived from Litopenaeus vannamei shrimp shell waste, which can be used in the pharmaceutical industry.

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