scholarly journals Hypericum perforatum and Azadirachta indica (Neem) oil in the management of chronic leg ulcers: An uncontrolled retrospective observational case review

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Lisa Turk ◽  
Tobias Thuile ◽  
Valentina De Marzi ◽  
Giovanni Antonacci ◽  
Mario Puviani ◽  
...  
Keyword(s):  
Azadirachta Indica ◽  
Wound Dressing ◽  
Hypericum Perforatum ◽  
Local Treatment ◽  
Wound Management ◽  
High Morbidity ◽  
Leg Ulcers ◽  
Case Review ◽  
Neem Oil ◽  
Chronic Leg Ulcers

Chronic nonhealing leg ulcers are debilitating with high morbidity in a vulnerable patient population and pose a frequent clinical and socioeconomic problem. Numerous local treatment options exist, but clinical trials are rare and wound management still represents a big challenge. Recently a wound dressing based on the natural remedies Hypericum perforatum and Neem oil has been proposed for chronic wound management, but trials on nonhealing leg ulcers are missing. Uncontrolled retrospective observational case review on all patients under our supervision with chronic leg ulcers who underwent treatment with a plant-derived wound dressing based on Hypericum perforatum and Azadirachta indica (Neem) oil. It could be retrieved in a total 16 cases (11 female) with a median age of 71 years. All ulcers (7 ulcers on the leg and 9 ulcers on the feed) showed a complete healing after a median healing time of 82 days (Mean 85, range 14-180 days). No side effects occurred, medication was painless or even reduced pain. Wound dressings based on Hypericum perforatum and Neem oil are well tolerated and could be a potential additional simple treatment option in the management of non-healing leg ulcers. Prospective controlled trials are needed to confirm these observations.

scholarly journals Use of Neem oil and Hypericum perforatum for treatment of calcinosis-related skin ulcers in systemic sclerosis

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051988217
Author(s):  
Dilia Giuggioli ◽  
Federica Lumetti ◽  
Amelia Spinella ◽  
Emanuele Cocchiara ◽  
Gianluca Sighinolfi ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Hypericum Perforatum ◽  
Rating Scale ◽  
Local Treatment ◽  
Skin Lesions ◽  
Complete Healing ◽  
Control Group ◽  
Neem Oil ◽  
Skin Ulcers ◽  
Calcium Deposits

Objective This study evaluated Neem oil and Hypericum perforatum (Holoil®) for treatment of scleroderma skin ulcers related to calcinosis (SU-calc). Procedure: We retrospectively analyzed 21 consecutive systemic sclerosis (SSc) patients with a total of 33 SU-calcs treated daily with Holoil® cream compared with a control group of 20 patients with 26 SU-calcs. Holoil® was directly applied to skin lesions, while the control group received only standard medication. Results Application of Holoil® either resulted in crushing and complete resolution of calcium deposits or facilitated sharp excision of calcinosis during wound care sessions in 27/33 cases (81.8%). Complete healing of SU-calc occurred in 15/33 (45%) of cases within a time period of 40.1 ± 16.3 (mean ± SD) days, while 18/33 (55%) of lesions improved in terms of size, erythema, fibrin and calcium deposits. Patients reported a reduction of pain (mean numeric rating scale 7.3 ± 1.9 at baseline versus 2.9 ± 1.4 at follow-up) The control group had longer healing times and a higher percentage of infections. Conclusions The efficacy of local treatment with neem oil and Hypericum perforatum suggest that Holoil® could be a promising tool in the management of SSc SU-calc.

Chronic leg ulcers in Sweden: a survey of wound management

2000 ◽  
Vol 9 (3) ◽  
pp. 131-136 ◽  
Author(s):  
K. Hjelm ◽  
P. Nyberg ◽  
J. Apelqvist
Keyword(s):  
Wound Management ◽  
Leg Ulcers ◽  
Chronic Leg Ulcers

Causes and the way of treatment of patients with chronic leg ulcers

Phlebologie ◽  
2009 ◽  
Vol 38 (05) ◽  
pp. 211-218 ◽  
Author(s):  
C. Wax ◽  
A. Körber ◽  
J. Dissemond ◽  
J. Klode
Keyword(s):  
Treatment Period ◽  
General Practitioners ◽  
Peripheral Arterial Occlusive Disease ◽  
Mean Value ◽  
Arterial Occlusive Disease ◽  
Leg Ulcer ◽  
Leg Ulcers ◽  
Patient Will ◽  
Peripheral Arterial ◽  
Chronic Leg Ulcers

SummaryChronic leg ulcer may have various causes, which are currently not centrally recorded in Germany. It is also unclear who treats patients with chronic leg ulcers in Germany and how the basic implementation of diagnosis and treatment of these patients looks like. Patients, methods: Therefore, we started a survey of 1000 general practitioners and practising specialists in dermatology, surgery and phlebology in five different regions of Germany. We carried out the genesis of a total of 6275 patients from 62 different practising therapists, 33 specialists in dermatology, surgery or phlebology and 29 general practitioners. Results: In 66.1% of all patients we found a venous leg ulcer, in 9.1% a leg ulcer from peripheral arterial occlusive disease, and in 8.5% a mixture of both. Thus there suffered a total of 83.8% of patients on chronic venous insufficiency or peripheral arterial occlusive disease as a major factor in the genesis of the chronic leg ulcer. However, even the rarely diagnosed entities such as exogenous factors, vasculitis, pyoderma gangrenosum or infectious diseases are occur in summation in 16.2% of all patients and should therefore be known and excluded. In addition, the treatment periods and referral routes of patients with chronic leg ulcer should be identified. The analysis showed that the vast majority (86.8%) of patients with chronic ulcers who were investigated by us is treated by specialists. The treatment duration of general practitioners is 6.3 weeks (mean value) before the patient will be referred to a specialist. This treatment period is significantly shorter compared to the treatment period of the specialists, who treat their patients 14.1 weeks (mean value) before the patient will be referred to another specialist or to a clinic. Conclusion: Our results show the current aspects of aetiology and the way of treatment of patients with chronic leg ulcers in Germany.

Ulcer osteoma and periosteal reactions to chronic leg ulcers.

1997 ◽  
Vol 168 (1) ◽  
pp. 155-157 ◽  
Author(s):  
D Karasick ◽  
M E Schweitzer ◽  
D M Deely
Keyword(s):  
Leg Ulcers ◽  
Chronic Leg Ulcers

Effectiveness of Neem (Azadirachta indica A. Juss) Oil against Decay Fungi

2017 ◽  
Vol 5 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Kanchan Rawat ◽  
◽  
Uttam Kumar Sahoo ◽  
Nagaraj Hegde ◽  
Awadhesh Kumar ◽  
...  
Keyword(s):  
Azadirachta Indica ◽  
Schizophyllum Commune ◽  
Antimicrobial Properties ◽  
Fusarium Proliferatum ◽  
Wood Preservatives ◽  
Neem Oil ◽  
Environment Friendly ◽  
Decay Fungi ◽  
Natural Oils ◽  
Mycelia Growth

The enormous use of metallic wood preservatives has caused destructive impact on environment as well as human health. Therefore realizing the urgency of switching to Environment friendly options such as natural oils are being tested for their antimicrobial properties. The present study aimed at investigating potential of Neem oil against the growth ofdecaying fungi. The ability of Neem oil to inhibit mycelia growth of Schizophyllum commune, Fusarium oxysporum, Fusarium proliferatum, Coniophora puteana and Alternaria alternata was tested at different concentrations of 0.25, 0.50, 0.75, 1.0, 2.0, 4.0, 6.0, 8.0 and 10%. Results of the study revealed Neem oil concentrations above 2% were significantly inhibitory to all the tested fungi.

scholarly journals The Effects of Silver-Releasing Foam Dressings on Diabetic Foot Ulcer Healing

2021 ◽  
Vol 10 (7) ◽  
pp. 1495
Author(s):  
Yu-Chi Wang ◽  
Hsiao-Chen Lee ◽  
Chien-Lin Chen ◽  
Ming-Chun Kuo ◽  
Savitha Ramachandran ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Rate ◽  
Early Period ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Management ◽  
Control Group ◽  
Diabetic Patients ◽  
High Morbidity

Diabetic foot ulcers (DFUs) are a serious complication in diabetic patients and lead to high morbidity and mortality. Numerous dressings have been developed to facilitate wound healing of DFUs. This study investigated the wound healing efficacy of silver-releasing foam dressings versus silver-containing cream in managing outpatients with DFUs. Sixty patients with Wagner Grade 1 to 2 DFUs were recruited. The treatment group received silver-releasing foam dressing (Biatain® Ag Non-Adhesive Foam dressing; Coloplast, Humlebaek, Denmark). The control group received 1% silver sulfadiazine (SSD) cream. The ulcer area in the silver foam group was significantly reduced compared with that in the SSD group after four weeks of treatment (silver foam group: 76.43 ± 7.41%, SSD group: 27.00 ± 4.95%, p < 0.001). The weekly wound healing rate in the silver foam group was superior to the SSD group during the first three weeks of treatment (p < 0.05). The silver-releasing foam dressing is more effective than SSD in promoting wound healing of DFUs. The effect is more pronounced in the initial three weeks of the treatment. Thus, silver-releasing foam could be an effective wound dressing for DFUs, mainly in the early period of wound management.

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