pH-Controlled drug delivery with hybrid aerogel of chitosan, carboxymethyl cellulose and graphene oxide as the carrier

2017 ◽  
Vol 103 ◽  
pp. 248-253 ◽  
Author(s):  
Ren Wang ◽  
Dan Shou ◽  
Ouyang Lv ◽  
Yong Kong ◽  
Linhong Deng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Carboxymethyl Cellulose ◽  
Controlled Drug Delivery ◽  
Ph Controlled ◽  
Hybrid Aerogel

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

scholarly journals Electrically Controlled Drug Delivery from Graphene Oxide Nanocomposite Films

ACS Nano ◽  
2014 ◽  
Vol 8 (2) ◽  
pp. 1834-1843 ◽  
Author(s):  
Cassandra L. Weaver ◽  
Jaclyn M. LaRosa ◽  
Xiliang Luo ◽  
Xinyan Tracy Cui
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Drug Delivery ◽  
Nanocomposite Films

scholarly journals Hydrazone-Containing Triblock Copolymeric Micelles for pH-Controlled Drug Delivery

2018 ◽  
Vol 9 ◽  
Author(s):  
Peilan Qi ◽  
Xiaohe Wu ◽  
Lei Liu ◽  
Huimin Yu ◽  
Shiyong Song
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Ph Controlled

pH-controlled silicone microspheres for controlled drug delivery

1995 ◽  
Vol 33 (1) ◽  
pp. 163-171 ◽  
Author(s):  
R. Sutinen ◽  
V. Laasanen ◽  
P. Paronen ◽  
A. Urtti
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Ph Controlled
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