Hyaluronic acid coated Pluronic F127/Pluronic P123 mixed micelle for targeted delivery of Paclitaxel and Curcumin

2021 ◽  
Author(s):  
T.S. Anirudhan ◽  
Susan Varghese ◽  
V. Manjusha
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Mixed Micelle ◽  
Pluronic F127 ◽  
Pluronic P123

scholarly journals Rational Design of Hyaluronic Acid-Based Copolymer-Mixed Micelle in Combination PD-L1 Immune Checkpoint Blockade for Enhanced Chemo-Immunotherapy of Melanoma

2021 ◽  
Vol 9 ◽  
Author(s):  
Chaopei Zhou ◽  
Xiuxiu Dong ◽  
Chunxiang Song ◽  
Shuang Cui ◽  
Tiantian Chen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Cells ◽  
Immune Checkpoint ◽  
Targeted Delivery ◽  
Rational Design ◽  
Mixed Micelle ◽  
Tumor Therapy ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Therapy Strategy

The application of combinational therapy breaks the limitation of monotherapy and achieves better clinical benefit for tumor therapy. Herein, a hyaluronic acid/Pluronic F68-based copolymer-mixed micelle was constructed for targeted delivery of chemotherapeutical agent docetaxel (PHDM) in combination with programmed cell death ligand-1(PD-L1) antibody. When PHDM+anti-PDL1 was injected into the blood system, PHDM could accumulate into tumor sites and target tumor cells via CD44-mediated endocytosis and possess tumor chemotherapy. While anti-PDL1 could target PD-L1 protein expressed on surface of tumor cells to the immune checkpoint blockade characteristic for tumor immunotherapy. This strategy could not only directly kill tumor cells but also improve CD8+ T cell level and facilitate effector cytokines release. In conclusion, the rational-designed PHDM+anti-PDL1 therapy strategy creates a new way for tumor immune-chemotherapy.

scholarly journals Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 321
Author(s):  
Shenghui Zhong ◽  
Peng Liu ◽  
Jinsong Ding ◽  
Wenhu Zhou
Keyword(s):  
Rheumatoid Arthritis ◽  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
High Dose ◽  
One Pot ◽  
Inflammatory Site ◽  
Pei Nanoparticles ◽  
Toxic Reactions

Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA); however, long-term and high-dose usage of MTX for patients can cause many side effects and toxic reactions. To address these difficulties, selectively delivering MTX to the inflammatory site of a joint is promising in the treatment of RA. In this study, we prepared MTX-PEI@HA nanoparticles (NPs), composed of hyaluronic acid (HA) as the hydrophilic negative electrical shell, and MTX-linked branched polyethyleneimine (MTX-PEI) NPs as the core. MTX-PEI@HA NPs were prepared in the water phase by a one-pot method. The polymeric NPs were selectively internalized via CD44 receptor-mediated endocytosis in the activated macrophages. In the in vivo mice mode study, treatment with MTX-PEI@HA NPs mitigated inflammatory arthritis with notable safety at a high dose of MTX. We highlight the distinct advantages of aqueous-synthesized NPs coated with HA for arthritis-selective targeted delivery, thus verifying MTX-PEI@HA NPs as a promising MTX-based nanoplatform for treatment of RA.

Co-administration of biocompatible self-assembled polylactic acid–hyaluronic acid block copolymer nanoparticles with tumor-penetrating peptide-iRGD for metastatic breast cancer therapy

2018 ◽  
Vol 6 (19) ◽  
pp. 3163-3180 ◽  
Author(s):  
Caifeng Deng ◽  
Xiaohong Xu ◽  
Drunp Tashi ◽  
Yongmei Wu ◽  
Bingyin Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Polylactic Acid ◽  
Targeted Delivery ◽  
Metastatic Breast ◽  
Chemotherapeutic Drugs ◽  
Breast Cancer Therapy

The safe and efficient targeted delivery of chemotherapeutic drugs has remained a challenge in metastatic breast cancer therapy.

scholarly journals Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells

Oncotarget ◽  
2016 ◽  
Vol 7 (23) ◽  
pp. 34158-34171 ◽  
Author(s):  
Stephen L. Hayward ◽  
Christina L. Wilson ◽  
Srivatsan Kidambi
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Glioblastoma Cells

scholarly journals Electrosprayed Nanoparticles Based on Hyaluronic Acid: Preparation and Characterization

Technologies ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 71
Author(s):  
Petr Snetkov ◽  
Kseniia Zakharova ◽  
Svetlana Morozkina ◽  
Mikhail Baranov ◽  
Roman Olekhnovich ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Average Diameter ◽  
Delivery Systems ◽  
Polymer Carriers ◽  
Modern Drug ◽  
Subsequent Application ◽  
Pharmaceutical Agents ◽  
Targeted Delivery Systems

Modern drug delivery systems demand the development of targeted polymer-carriers with the set of obligatory requirements. Thus, such capsules must have total biocompatibility, biodegradability, and possess non-allergenic, and non-tumorigenic properties. Hyaluronic acid (HA), as a natural linear polysaccharide that is included in the pericellular and extracellular matrixes, satisfies all these demands in the best possible way. In this study, the biopolymer nanoparticles with an average diameter of 300 nm were successfully obtained from aqueous HA solutions by electrospraying technique and characterized. Due to the presence of active functional groups in the structure of HA, such polymer particles can incorporate various pharmaceutical agents. This finding expands the investigation and subsequent application of drug-loaded nanoparticles based on HA as challenging and advanced targeted delivery systems.

Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells

2014 ◽  
Vol 114 ◽  
pp. 407-415 ◽  
Author(s):  
Tuan Hiep Tran ◽  
Ju Yeon Choi ◽  
Thiruganesh Ramasamy ◽  
Duy Hieu Truong ◽  
Chien Ngoc Nguyen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid
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