Biomarkers predicting metabolic syndrome: The role of adiponectin and systemic inflammation

2012 ◽  
Vol 155 (2) ◽  
pp. 286-287 ◽  
Author(s):  
Kyriakoula Marinou ◽  
Aristeidis G. Vaiopoulos ◽  
Michael Koutsilieris
Keyword(s):  
Metabolic Syndrome ◽  
Systemic Inflammation

scholarly journals Systemic Inflammation in Metabolic Syndrome: Increased Platelet and Leukocyte Activation, and Key Role of CX3CL1/CX3CR1 and CCL2/CCR2 Axes in Arterial Platelet-Proinflammatory Monocyte Adhesion

2019 ◽  
Vol 8 (5) ◽  
pp. 708 ◽  
Author(s):  
Patrice Marques ◽  
Aida Collado ◽  
Sergio Martinez-Hervás ◽  
Elena Domingo ◽  
Esther Benito ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Systemic Inflammation ◽  
Immune Cell ◽  
Flow Chamber ◽  
Low Grade ◽  
Monocyte Adhesion ◽  
The Metabolic Syndrome ◽  
Factor Α ◽  
Arterial Endothelium

Background: Metabolic syndrome is associated with low-grade systemic inflammation, which is a key driver of premature atherosclerosis. We characterized immune cell behavior in metabolic syndrome, its consequences, and the potential involvement of the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine axes. Methods: Whole blood from 18 patients with metabolic syndrome and 21 age-matched controls was analyzed by flow cytometry to determine the leukocyte immunophenotypes, activation, platelet-leukocyte aggregates, and CX3CR1 expression. ELISA determined the plasma marker levels. Platelet-leukocyte aggregates adhesion to tumor necrosis factor-α (TNFα)-stimulated arterial endothelium and the role of CX3CL1/CX3CR1 and CCL2/CCR2 axes was investigated with the parallel-plate flow chamber. Results: When compared with the controls, the metabolic syndrome patients presented greater percentages of eosinophils, CD3+ T lymphocytes, Mon2/Mon3 monocytes, platelet-eosinophil and -lymphocyte aggregates, activated platelets, neutrophils, eosinophils, monocytes, and CD8+ T cells, but lower percentages of Mon1 monocytes. Patients had increased circulating interleukin-8 (IL-8) and TNFα levels and decreased IL-4. CX3CR1 up-regulation in platelet-Mon1 monocyte aggregates in metabolic syndrome patients led to increased CX3CR1/CCR2-dependent platelet-Mon1 monocyte adhesion to dysfunctional arterial endothelium. Conclusion: We provide evidence of generalized immune activation in metabolic syndrome. Additionally, CX3CL1/CX3CR1 or CCL2/CCR2 axes are potential candidates for therapeutic intervention in cardiovascular disorders in metabolic syndrome patients, as their blockade impairs the augmented arterial platelet-Mon1 monocyte aggregate adhesiveness, which is a key event in atherogenesis.

scholarly journals Chronic systemic inflammation in pathways of metabolic syndrome associated with hyperandrogenism (review)

2020 ◽  
pp. 12-18
Author(s):  
И.А. Игумнов ◽  
Э.М. Шарифулин ◽  
Л.В. Беленькая ◽  
Л.М. Лазарева ◽  
А.В. Аталян ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Systemic Inflammation ◽  
Polycystic Ovary ◽  
Google Scholar ◽  
Current View ◽  
Ovary Syndrome ◽  
Metabolic Complications ◽  
Causal Nature ◽  
Search For Information

Данная статья представляет собой обзор публикаций по проблеме хронического системного воспаления (ХСВ) и его роли в патогенезе метаболического синдрома (МС), в частности, ассоциированного с гиперандрогенизмом (ГА). Цель: систематизация имеющихся данных о роли хронического системного воспаления в патогенезе метаболических осложнений гиперандрогенизма. Информационный поиск проводился с использованием интернет ресурсов (PubMed, EMBASE, Google Scholar, E-library), анализировались литературные источники за период 2000-2020 гг. В обзоре отражены современные представления о ХСВ и МС; описаны основные ассоциации МС и ГА. Продемонстрировано, что синдром поликистоза яичников (СПКЯ), как и МС, ассоциирован с ХСВ, инсулинорезистентностью и ожирением. При этом отмечено, что установить причинно-следственный характер данной связи не всегда представляется возможным. В заключительной части обзора обобщены сведения о наиболее значимых маркерах ХСВ, специфичных для МС и ГА. This review addresses aspects of chronic systemic inflammation and its role in the pathogenesis of metabolic syndrome (MS) associated with hyperandrogenism (HA). The objective of this review was to systematize available data on the role of chronic systemic inflammation in the pathogenesis of metabolic complications of hyperandrogenism. Search for information was performed in the PubMed, EMBASE, Google Scholar, and E-library databases; 2000-2020 information was analyzed. The article presents the current view on chronic systemic inflammation and MS; major associations of MS and hyperandrogenism (HA) are also described. Polycystic ovary syndrome (PCOS), as well as MS, was shown to be associated with chronic systemic inflammation, insulin resistance, and obesity. However, it is not always possible to establish the causal nature of this relationship. The final part of the review summarizes information about the most significant markers of chronic systemic inflammation, which are specific for MS and HA.

Glucocorticoid-induced metabolic syndrome: establishing the role of AgRP

2018 ◽  
Author(s):  
Charlotte Sefton ◽  
Erika Harno ◽  
Alison Davies ◽  
Tiffany-Jayne Allen ◽  
Jonathan R Wray ◽  
...  
Keyword(s):  
Metabolic Syndrome

The role of omentin in inflammation and metabolic syndrome risk assessment in women with PCO-S

2019 ◽  
Author(s):  
Iwona Zieleń-Zynek ◽  
Joanna Kowalska ◽  
Nowak Justyna ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Risk Assessment ◽  
Metabolic Syndrome
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