Prevalence and genotype distribution of human papillomavirus in women with cervical cancer or high-grade precancerous lesions in Chengdu, western China

(1) Background: Cervical cancer is one of the most common cancers in Korean women. This study was performed to discover the utility of HPV (Human Papillomavirus) testing in screening of cervical lesions and to provide the prevalence of HPV and the genotype distribution in a single center of Korea. (2) Methods: A total of 15,141 women who underwent both HPV testing and cervical cytology were enrolled in this retrospective medical record review study. (3) Results: HPV testing showed higher sensitivity than cytology for the detection of histological high-grade squamous lesions. Furthermore, the sensitivity and specificity of HPV testing varied depending on the method used. The BD Onclarity™ HPV assay had higher sensitivity (90%) than the MyHPV CHIP™ kit (all types of HPV: 82%; high-risk HPV: 76%) for high-grade squamous lesions. A combination of MyHPV CHIP™ and cytology detected 90.9% (30/33) of histological high-grade squamous lesions. A combination of BD Onclarity™ HPV assay and cytology detected 96.55% (84/87) of histological high-grade squamous lesions. In addition, HPV prevalence and genotype distribution were different depending on the HPV testing method used. (4) Conclusion: HPV testing showed higher sensitivity than cytology, but the sensitivity and specificity of HPV testing had variation depending on the method used.

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Impact of human papillomavirus coinfections on the risk of high-grade squamous intraepithelial lesion and cervical cancer

Gynecologic Oncology ◽

10.1016/j.ygyno.2014.06.018 ◽

2014 ◽

Vol 134 (3) ◽

pp. 534-539 ◽

Cited By ~ 22

Author(s):

Adela Carrillo-García ◽

Sergio Ponce-de-León-Rosales ◽

David Cantú-de-León ◽

Verónica Fragoso-Ontiveros ◽

Imelda Martínez-Ramírez ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

High Grade ◽

Squamous Intraepithelial Lesion ◽

Intraepithelial Lesion

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Human papillomavirus (HPV) genotyping by HPV DNA chip in cervical cancer and precancerous lesions

International Journal of Gynecological Cancer ◽

10.1111/j.1048-891x.2005.14417.x ◽

2005 ◽

Vol 15 (1) ◽

pp. 81-87 ◽

Cited By ~ 17

Author(s):

G.-Y. Lee ◽

S.-M. Kim ◽

S.-Y. Rim ◽

H.-S. Choi ◽

C.-S. Park ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Precancerous Lesions ◽

Dna Chip ◽

Hpv Dna ◽

Hpv Genotyping

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Prevalence of human papillomavirus and genotype distribution in women undergoing cervical cancer screening in the area of Barbastro, Spain

Revista Española de Patología ◽

10.1016/j.patol.2016.06.002 ◽

2016 ◽

Vol 49 (4) ◽

pp. 208-213

Author(s):

María Dolores Comes ◽

Rosa Oncíns ◽

Eduardo Clemente ◽

María Ángeles Aragón ◽

Ana Cortés ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Genotype Distribution

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Human papillomavirus detection in cervical scrapes from women attended in the Family Health Program

Revista Latino-Americana de Enfermagem ◽

10.1590/0104-1169.3189.2398 ◽

2014 ◽

Vol 22 (1) ◽

pp. 100-107 ◽

Cited By ~ 4

Author(s):

Everton Faccini Augusto ◽

Larissa Silva dos Santos ◽

Ledy do Horto dos Santos Oliveira

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

High Risk ◽

Health Program ◽

Vaccine Coverage ◽

Family Health ◽

Polymorphism Analysis ◽

Genotype Distribution ◽

Cross Sectional Survey ◽

Family Health Program

OBJECTIVES: to survey the prevalence of human papillomavirus, associated risk factors and genotype distribution in women who were referred to cervical cancer screening when attended in a Family Health Program. METHOD: we conducted a cross-sectional survey, investigating 351 women. Polymerase chain reaction for DNA amplification and restriction fragment length polymorphism analysis were used to detect and typify the papillomavirus. RESULTS: virus infection was detected in 8.8% of the samples. Among the 21 different genotypes identified in this study, 14 were high risk for cervical cancer, and the type 16 was the most prevalent type. The infection was associated with women who had non-stable sexual partners. Low risk types were associated with younger women, while the high risk group was linked to altered cytology. CONCLUSION: in this sample attended a Family Health Program, we found a low rate of papillomavirus infection. Virus frequency was associated to sexual behavior. However, the broad range of genotypes detected deserves attention regarding the vaccine coverage, which includes only HPV prevalent types.

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Acceptability and feasibility of human papillomavirus vaccination for adolescents in school environments in Libreville

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20203825 ◽

2020 ◽

Vol 9 (9) ◽

pp. 3541

Author(s):

Nathalie L. Ambounda ◽

Sylvain H. Woromogo ◽

Olive M. Kenmogne ◽

Felicite E. Yagata Moussa ◽

Vicky N. Simo Tekem ◽

...

Keyword(s):

Cervical Cancer ◽

Human Papillomavirus ◽

High Risk ◽

Precancerous Lesions ◽

Hpv Vaccination ◽

Immunization Coverage ◽

Human Papillomaviruses ◽

Professional Status ◽

Human Papillomavirus Vaccination ◽

Cross Sectional

Background: High-risk oncogenic human papillomaviruses (HPV) are the cause of sexually transmitted viral infection. Its persistence is a risk factor for precancerous lesions of the cervix, which will constitute the base of cervical cancer. In the world, the prevalence of high-risk oncogenic HPV is 66.7%, which is higher among women starting their sexual activity.Methods: An analytical cross-sectional study was conducted in high schools in Gabon regarding parents. The variables selected were the socio-cultural and demographic characteristics of the parents, their knowledge of human papillomavirus vaccination and their acceptability of HPV vaccination and finally the feasibility of HPV vaccination. The statistical test used was Pearson's Chi-square, and a difference was considered significant for p<0.05.Results: The majority of parents, 89%, were informed of the existence of cervical cancer. However, 73.4% of them were unaware of the existence of vaccination against cervical cancer. Only 2.4% of parents had vaccinated their daughters against cervical cancer at the time of the study. These parents only 53.4% expressed an interest in vaccinating their daughters in 53.4% of cases. The ability to vaccinate children is associated with the socio-professional status of parents (p˂0.000).Conclusions: The majority of parents approved school-based vaccination against human papillomavirus infections despite its reported cost and lack of information. The integration of anti-HPV vaccination into the expanded programme on immunization in Gabon will improve immunization coverage.

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