Core–shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect

2015 ◽  
Vol 484 (1-2) ◽  
pp. 163-171 ◽  
Author(s):  
Wei He ◽  
Yaqi Lv ◽  
Yaping Zhao ◽  
Chaoran Xu ◽  
Zhu Jin ◽  
...  
Keyword(s):  
Drug Release ◽  
Antitumor Effect ◽  
Core Shell ◽  
Sustained Drug Release

Multifunctional core-shell silica microspheres and their performance in self-carrier decomposition, sustained drug release and fluorescent bioimaging

2018 ◽  
Vol 263 ◽  
pp. 148-156 ◽  
Author(s):  
Yamina Ait Mehdi ◽  
Asma Itatahine ◽  
Meriem Fizir ◽  
Deli Xiao ◽  
Pierre Dramou ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Silica Microspheres ◽  
Sustained Drug Release

scholarly journals Electrospray-mediated preparation of compositionally homogeneous core–shell hydrogel microspheres for sustained drug release

RSC Advances ◽  
2017 ◽  
Vol 7 (70) ◽  
pp. 44482-44491 ◽  
Author(s):  
Wing-Fu Lai ◽  
Andrei S. Susha ◽  
Andrey L. Rogach ◽  
Guoan Wang ◽  
Minjian Huang ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Sustained Drug Release ◽  
Homogeneous Core ◽  
Hydrogel Microspheres

Compositionally homogeneous core–shell hydrogel microspheres were prepared for sustained drug release.

Luminescent core–shell Ca2MoO5:Eu3+-MCM-41 structure for sustained drug release

2021 ◽  
Vol 22 ◽  
pp. 100581
Author(s):  
A.I. Karacolak ◽  
F.M. Emen ◽  
D. Kılıç ◽  
E. Kutlu ◽  
M.A. Ali ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Sustained Drug Release ◽  
Mcm 41

Novel core–shell dextran–hemin crosslinked micelles: synthesis, photo-controlled drug release and excellent (synergetic) antitumor effect

2015 ◽  
Vol 3 (7) ◽  
pp. 1439-1445 ◽  
Author(s):  
Qingbo Yu ◽  
Anjian Xie ◽  
Yazhong Xiao ◽  
Shikuo Li ◽  
Fangzhi Huang ◽  
...  
Keyword(s):  
Drug Release ◽  
Antitumor Effect ◽  
Controlled Drug Release ◽  
Core Shell ◽  
Crosslinked Micelles

In this study, novel core–shell crosslinked dextran–hemin micelles were first successfully synthesized.

Core-shell biopolymer microspheres for sustained drug release

2014 ◽  
Vol 132 (14) ◽  
pp. n/a-n/a ◽  
Author(s):  
Liqing Tan ◽  
Tao Jiang ◽  
Xiaolan Yang ◽  
Wei Li ◽  
Lijun Pan ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Sustained Drug Release

Synthesis, Characterization and in-vitro drug release studies of a macromolecular prodrug of Didanosine.

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Neeraj Agrawal ◽  
M.J. Chandrasekar ◽  
U.V. Sara ◽  
Rohini A.
Keyword(s):  
Drug Release ◽  
Drug Level ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Alkaline Environment ◽  
Stomach Acid ◽  
Release Studies ◽  
Macromolecular Prodrug

A macromolecular prodrug of didanosine (ddI) for oral administration was synthesized and evaluated for in-vitro drug release profile. Didanosine was first coupled to 2-hydroxy ethyl methacrylate (HEMA) through a succinic spacer to form HEMA-Suc-ddI monomeric conjugate which was subsequently polymerized to yield Poly(HEMA-Suc-ddI) conjugate. The structures of the synthesized compounds were characterized by FT-IR, Mass and 1H-NMR spectroscopy. The prodrug was subjected for in-vitro drug release studies in buffers of pH 1.2 and 7.4 mimicking the upper and lower GIT. The results showed that the drug release from the polymeric backbone takes place in a sustained manner over a period of 24 h and the amount of drug released was comparatively higher at pH 7.4 indicating that the drug release takes place predominantly at the alkaline environment of the lower GIT rather than at the acidic environment of the upper GIT. This pH dependent sustained drug release behavior of the prodrug may be capable of reducing the dose limiting toxicities by maintaining the plasma drug level within the therapeutic range and increasing t1/2 of ddI. Moreover, the bioavailability of the drug should be improved as the prodrug releases ddI predominantly in the alkaline environment which will reduce the degradation of ddI in the stomach acid.

Formulation and Evaluation of Chitosan-Polyaniline Nanocomposites for Controlled Release of Anticancer Drug Doxorubicin

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Dillip Kumar Behera ◽  
Kampal Mishra ◽  
Padmolochan Nayak
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Nanocomposite Films ◽  
Casting Method ◽  
Sustained Drug Release ◽  
In Vitro Drug Release ◽  
Clay Particles ◽  
Solution Casting Method ◽  
Nanoclay Content

In this present work, chitosan (CS) crosslink with polyaniline (PANI) with montmorilonite (MMT) called as (CSPANI/MMT) and CS crosslink with PANI without MMT called as (CS-PANI) were prepared by employing the solution casting method. Further the formation of nanocomposites CS-PANI/MMT and CS-PANI were investigated using XRD, FTIR, SEM and tensile strength. Water uptake and swelling ratio of the CS-PANI and CS-PANI/MMT were found to decrease with increase in concentration of clay. Mechanical properties of the CS-PANI and CS-PANI/MMT were assessed in terms of tensile strength and extensibility using texture analyzer. Increase in tensile strength and reduction in extensibility was reported with increase in the nanoclay content. In vitro drug release study on CS-PANI and CS-PANI/MMT indicated pronounced sustained release of doxorubicin by the incorporation of clay particles in the CS polymer matrix. Overall CSPANI/MMT nanocomposite films exhibited improved mechanical and sustained drug release properties than CS-PANI.

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