Efficient optimization of high-dose formulation of novel lyophilizates for dry powder inhalation by the combination of response surface methodology and time-of-flight measurement

2020 ◽  
Vol 581 ◽  
pp. 119255
Author(s):  
Ryo Ohori ◽  
Sakurako Kiuchi ◽  
Shintaro Sugiyama ◽  
Kahori Miyamoto ◽  
Tomomi Akita ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Time Of Flight ◽  
High Dose ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Dose Formulation ◽  
Flight Measurement

scholarly journals Optimization of Antimony Removal by Coagulation-Flocculation-Sedimentation Process Using Response Surface Methodology

Processes ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 117
Author(s):  
Muhammad Ali Inam ◽  
Rizwan Khan ◽  
Ick Tae Yeom ◽  
Abdul Salam Buller ◽  
Muhammad Akram ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Environmental Water ◽  
High Dose ◽  
Operating Variables ◽  
Model Response ◽  
Aqueous Environments ◽  
Optimum Ph ◽  
Potential Risks ◽  
Good Agreement

Coprecipitation-adsorption plays a significant role during coagulation-flocculation-sedimentation (C/F/S) of antimony (Sb) in water. This work uses a Box–Behnken statistical experiment design (BBD) and response surface methodology (RSM) to investigate the effects of major operating variables such as initial Sb(III, V) concentration (100–1000 µg/L), ferric chloride (FC) dose (5–50 mg/L), and pH (4–10) on redox Sb species. Experimental data of Sb(III, V) removal were used to determine response function coefficients. The model response value (Sb removal) showed good agreement with the experimental results. FC showed promising coagulation behavior of both Sb species under optimum pH (6.5–7.5) due to its high affinity towards Sb species and low residual Fe concentration. However, a high dose of 50 mg/L of FC is required for the maximum (88–93%) removal of Sb(V), but also for the highest (92–98%) removal of low initial concentrations of Sb(III). Furthermore, BBD and RSM were found to be reliable and feasible for determining the optimum conditions for Sb removal from environmental water samples by a C/F/S process. This work may contribute to a better understanding and prediction of the C/F/S behavior of Sb(III, V) species in aqueous environments, to reduce potential risks to humans.

scholarly journals Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops® High Dose Dry Powder Inhalation Device While Maintaining Dispersibility

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 645
Author(s):  
Imco Sibum ◽  
Paul Hagedoorn ◽  
Carel O. Botterman ◽  
Henderik W. Frijlink ◽  
Floris Grasmeijer
Keyword(s):  
Fine Particle ◽  
Pressure Range ◽  
Maximum Dose ◽  
Vacuum Pressure ◽  
High Dose ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Fine Particle Dose ◽  
Nominal Dose ◽  
Particle Dose

In recent years there has been increasing interest in the pulmonary delivery of high dose dry powder drugs, such as antibiotics. Drugs in this class need to be dosed in doses far over 2.5 mg, and the use of excipients should therefore be minimized. To our knowledge, the effect of the automatic filling of high dose drug formulations on the maximum dose that can be filled in powder inhalers, and on the dispersion behavior of the powder, have not been described so far. In this study, we aimed to investigate these effects after filling with an Omnidose, a vacuum drum filler. Furthermore, the precision and accuracy of the filling process were investigated. Two formulations were used—an isoniazid formulation we reported previously and an amikacin formulation. Both formulations could be precisely and accurately dosed in a vacuum pressure range of 200 to 600 mbar. No change in dispersion was seen after automatic filling. Retention was decreased, with an optimum vacuum pressure range found from 400 to 600 mbar. The nominal dose for amikacin was 57 mg, which resulted in a fine particle dose of 47.26 ± 1.72 mg. The nominal dose for isoniazid could be increased to 150 mg, resulting in a fine particle dose of 107.35 ± 13.52 mg. These findings may contribute to the understanding of the upscaling of high dose dry powder inhalation products.

Pharmacokinetics and tolerability of formoterol in healthy volunteers after a single high dose of Foradil dry powder Inhalation via aerolizer TM

1999 ◽  
Vol 55 (2) ◽  
pp. 131-138 ◽  
Author(s):  
J. B. Lecaillon ◽  
G. Kaiser ◽  
M. Palmisano ◽  
J. Morgan ◽  
G. Della Cioppa
Keyword(s):  
Healthy Volunteers ◽  
High Dose ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Single High Dose

scholarly journals Optimization of Very Low-Dose Formulation of Vitamin D3 with Lyophilizate for Dry Powder Inhalation System by Simple Method Based on Time-of-Flight Theory

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 632
Author(s):  
Kahori Miyamoto ◽  
Misato Yanagisawa ◽  
Hiroaki Taga ◽  
Hiromichi Yamaji ◽  
Tomomi Akita ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Vitamin D3 ◽  
Low Dose ◽  
Time Of Flight ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Simple Method ◽  
Aerodynamic Particle Size

It has been previously reported that active vitamin D3 (VD3) is a candidate drug that can repair alveolar damage in chronic obstructive pulmonary disease at a very low dose. We herein report the optimization of a very low-dose formulation of VD3 for dry powder inhalation by a simple method based on time-of-flight (TOF) theory. As the preparation content of VD3 is very low, aerodynamic particle size distribution cannot be measured by pharmacopeial methods that require quantification of the main drug. Thus, a simple method based on TOF theory, which can measure aerodynamic particle size distribution without quantification, was used. The optimized formulation for an inhalation system using a lyophilized cake contained phenylalanine as the excipient (VD3 1 μg/vial + phenylalanine 0.3 mg/vial) and showed high performance with fine particle fraction ≤ 3 μm = 47.2 ± 4.4%. The difference between the results of pharmacopeial methods and simple method was examined using the formulation containing 10 µg/vial of VD3 and was within 5.0%. The preparation is expected to efficiently deliver VD3 to the lungs. Our simple method can optimize dry powder inhalation formulations more easily and rapidly even when the content of the main drug in a preparation is very low.

Optimization of Ultrasonic-Assisted Extraction of Embelin from Embelia ribes using Response Surface Methodology

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Mujeeb ◽  
S Alam ◽  
M Akhtar ◽  
AK Najmi ◽  
M Aqil ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Embelia Ribes ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction
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