Recent Advances in Physical Approaches for Transdermal Penetration Enhancement

2012 ◽  
Vol 7 (3) ◽  
pp. 184-197 ◽  
Author(s):  
HJessy Shaji ◽  
Dhanila Varkey
Keyword(s):  
Transdermal Delivery ◽  
Fluorescent Dyes ◽  
Skin Barrier ◽  
Penetration Enhancement ◽  
Transport Barrier ◽  
Novel Technologies ◽  
Combination Strategies ◽  
Recent Advances ◽  
Transdermal Drug Delivery Systems ◽  
Transdermal Penetration

Transdermal delivery offers opportunities for inventive, challenging and valuable research with patient benefits. However, the prominent challenge in designing transdermal drug delivery systems is to overcome the natural transport barrier of the skin, the stratum corneum. Several physical and chemical enhancement techniques have been investigated in the last decade to breach the skin barrier and assist the transport of macromolecules across skin. Recent technological advances in this field include novel combination strategies of penetration enhancement techniques, microneedle array designs, needle-free technologies, nanocarriers, metered dose and microstructured transdermal systems. The present review reports on recent advances in physical approaches towards enhanced transdermal penetration. Enhancement strategies comprehensively covered in this review emphasize the significant achievements gained through successful transdermal delivery of hydrophilic macromolecules, vaccines, proteins, peptides, oligonucleotides, fluorescent dyes and plasmid delivery. Some commercially available technologies for transdermal delivery have also been covered. These novel technologies hold immense potential to advance further into clinical practice and enable better therapeutic applications and prophylactic interventions for various diseases.

scholarly journals THE THE MICROEMULSION AS A KEY PLAYER IN CONQUERING THE SKIN BARRIER FOR THE AIM OF TRANSDERMAL DELIVERY OF DRUGS: REVIEWING A SUCCESSFUL DECADE

2019 ◽  
pp. 34-48
Author(s):  
RANIA YEHIA ◽  
DALIA A ATTIA
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Barrier ◽  
The Other ◽  
Penetration Enhancers ◽  
The Past ◽  
Transdermal Drug Delivery Systems ◽  
The One

Microemulsion (ME) systems are now considered of the most successful transdermal drug delivery systems. This is due to their nanodroplets size in the one hand and to their composition that enables the use of several mechanistically penetration enhancers in the same formulation on the other hand. This work summarizes the types, properties, and the merits of the use of MEs for transdermal delivery and reviews the successful studies that were performed to deliver several drugs through this important route during the past 10–12 years.

Transcending the Cutaneous Barrier Through Nanocarrier Exploration for Passive Delivery of Anti-hypertensive Drugs: A Critical Review

2020 ◽  
Vol 14 (3) ◽  
pp. 193-209
Author(s):  
Lalit Kumar ◽  
Puneet Utreja
Keyword(s):  
Patient Compliance ◽  
Transdermal Delivery ◽  
Antihypertensive Drugs ◽  
Skin Barrier ◽  
Oral Route ◽  
Term Treatment ◽  
New Approaches ◽  
Long Term Treatment ◽  
First Pass ◽  
Transdermal Route

Background: Hypertension comes under the category of chronic disease, which requires long term treatment. Hypertension is usually treated by oral administration of various therapeutic agents. There are several limitations of the oral route, making pharmaceutical scientists to discover an alternative route for drug delivery. Methods: The transdermal route may be a better alternative as it shows various advantages like lack of first-pass effect and high patient compliance. The skin may act as a primary barrier for the transdermal delivery of anti-hypertensive drugs; therefore, new approaches are required to cross this barrier. Nanocarrier systems come under these new approaches to cross the skin barrier. Various nanocarrier systems explored for transdermal delivery of antihypertensive drugs are liposomes, elastic liposomes, ethosomes, transethosomes, oleic acid vesicles, niosomes, solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions/microemulsions, and carbon nanotubes. Results: This review summarizes the potential of advanced nanocarrier systems for effective management of hypertension following the transdermal route. The entire literature search regarding the utility of nanocarrier systems in transdermal delivery of antihypertensive drugs was done by using Pubmed and Google Scholar. Conclusion: Nanocarrier systems are capable of reducing various drawbacks of conventional formulations of antihypertensive drugs like excessive first-pass effects, high dosing frequency, and toxicity promoting high patient compliance. However, the clinical efficacy determination of such nanocarrier systems is still a challenge and it will govern their presence in the global pharmaceutical market.

scholarly journals Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

2021 ◽  
Vol 10 (2) ◽  
pp. 181
Author(s):  
Vahid Alimardani ◽  
Samira Sadat Abolmaali ◽  
Gholamhossein Yousefi ◽  
Zahra Rahiminezhad ◽  
Mehdi Abedi ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Therapeutic Agents ◽  
Inorganic Nanoparticles ◽  
Microneedle Array ◽  
Wide Range ◽  
Microneedle Arrays

Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs’ challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

scholarly journals Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs

2021 ◽  
Author(s):  
Ting Liu ◽  
Minglong Chen ◽  
Jintao Fu ◽  
Ying Sun ◽  
Chao Lu ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Peptide Drugs ◽  
Recent Advances

scholarly journals Layer-by-Layer 3D Constructs of Fibroblasts in Hydrogel for Examining Transdermal Penetration Capability of Nanoparticles

2016 ◽  
Vol 22 (4) ◽  
pp. 447-453 ◽  
Author(s):  
Xiaochun Hou ◽  
Shiying Liu ◽  
Min Wang ◽  
Christian Wiraja ◽  
Wei Huang ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Three Dimensional ◽  
Layer By Layer ◽  
Surface Charges ◽  
Skin Model ◽  
Collagen Hydrogel ◽  
Penetration Ability ◽  
Charged Nanoparticles ◽  
Transdermal Penetration ◽  
Positively Charged

Nanoparticles are emerging transdermal delivery systems. Their size and surface properties determine their efficacy and efficiency to penetrate through the skin layers. This work utilizes three-dimensional (3D) bioprinting technology to generate a simplified artificial skin model to rapidly screen nanoparticles for their transdermal penetration ability. Specifically, this model is built through layer-by-layer alternate printing of blank collagen hydrogel and fibroblasts. Through controlling valve on-time, the spacing between printing lines could be accurately tuned, which could enable modulation of cell infiltration in the future. To confirm the effectiveness of this platform, a 3D construct with one layer of fibroblasts sandwiched between two layers of collagen hydrogel is used to screen silica nanoparticles with different surface charges for their penetration ability, with positively charged nanoparticles demonstrating deeper penetration, consistent with the observation from an existing study involving living skin tissue.

Recent Advances in Medical Device Triage Technologies for Chemical, Biological, Radiological, and Nuclear Events

2015 ◽  
Vol 30 (3) ◽  
pp. 320-323 ◽  
Author(s):  
Krystal Lansdowne ◽  
Christopher G. Scully ◽  
Loriano Galeotti ◽  
Suzanne Schwartz ◽  
David Marcozzi ◽  
...  
Keyword(s):  
Medical Device ◽  
Emerging Infectious Diseases ◽  
Science Research ◽  
Identification System ◽  
Publication Type ◽  
Novel Technologies ◽  
Medical Apps ◽  
Recent Advances ◽  
Nuclear Events ◽  
Medical Countermeasures

AbstractIn 2010, the US Food and Drug Administration (Silver Spring, Maryland USA) created the Medical Countermeasures Initiative with the mission of development and promoting medical countermeasures that would be needed to protect the nation from identified, high‐priority chemical, biological, radiological, or nuclear (CBRN) threats and emerging infectious diseases. The aim of this review was to promote regulatory science research of medical devices and to analyze how the devices can be employed in different CBRN scenarios. Triage in CBRN scenarios presents unique challenges for first responders because the effects of CBRN agents and the clinical presentations of casualties at each triage stage can vary. The uniqueness of a CBRN event can render standard patient monitoring medical device and conventional triage algorithms ineffective. Despite the challenges, there have been recent advances in CBRN triage technology that include: novel technologies; mobile medical applications (“medical apps”) for CBRN disasters; electronic triage tags, such as eTriage; diagnostic field devices, such as the Joint Biological Agent Identification System; and decision support systems, such as the Chemical Hazards Emergency Medical Management Intelligent Syndromes Tool (CHEMM-IST). Further research and medical device validation can help to advance prehospital triage technology for CBRN events.LansdowneK, ScullyCG, GaleottiL, SchwartzS, MarcozziD, StraussDG. Recent advances in medical device triage technologies for chemical, biological, radiological, and nuclear events. Prehosp Disaster Med. 2015;30(3):1-4

scholarly journals Recent advances of novel technologies for quality consistency assessment of natural herbal medicines and preparations

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Xi-Chuan Wei ◽  
Bo Cao ◽  
Chuan-Hong Luo ◽  
Hao-Zhou Huang ◽  
Peng Tan ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Novel Technologies ◽  
Recent Advances
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