Comparison of Surgery and Postoperative Radiation to Definitive Chemoradiation for Locally Advanced Squamous Cell Carcinoma of the Oral Cavity: An Analysis of the National Cancer Data Base

2016 ◽  
Vol 96 (2) ◽  
pp. E345
Author(s):  
M.T. Spiotto ◽  
M. Koshy
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Data Base ◽  
Squamous Cell ◽  
Locally Advanced ◽  
National Cancer Data Base ◽  
Advanced Squamous Cell Carcinoma ◽  
Postoperative Radiation ◽  
Cancer Data

Impact of facility volume on outcomes in patients with squamous cell carcinoma of the anal canal: Analysis of the National Cancer Data Base

Cancer ◽  
2016 ◽  
Vol 123 (2) ◽  
pp. 228-236 ◽  
Author(s):  
Arya Amini ◽  
Bernard L. Jones ◽  
Debashis Ghosh ◽  
Tracey E. Schefter ◽  
Karyn A. Goodman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Anal Canal ◽  
Cell Carcinoma ◽  
Data Base ◽  
Squamous Cell ◽  
National Cancer Data Base ◽  
Cancer Data

scholarly journals Combined high-intensity local treatment and systemic therapy in metastatic head and neck squamous cell carcinoma: An analysis of the National Cancer Data Base

Cancer ◽  
2017 ◽  
Vol 123 (23) ◽  
pp. 4583-4593 ◽  
Author(s):  
Zachary S. Zumsteg ◽  
Michael Luu ◽  
Emi J. Yoshida ◽  
Sungjin Kim ◽  
Mourad Tighiouart ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Data Base ◽  
Squamous Cell ◽  
Systemic Therapy ◽  
High Intensity ◽  
Local Treatment ◽  
National Cancer Data Base ◽  
Cancer Data

A Consideration for Surgical Management in Select T4b Oral Cavity Squamous Cell Carcinoma

2021 ◽  
pp. 000348942110382
Author(s):  
Michelle M. Chen ◽  
Clifford M. Chang ◽  
Sarah Dermody ◽  
Andrew J. Rosko ◽  
Michelle L. Mierzwa ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
National Cancer Data Base ◽  
High Rate ◽  
Cancer Data ◽  
Chi Squared ◽  
Similar Survival

Objectives: The role of surgery for conventionally “unresectable” (cT4b) oral cavity squamous cell carcinoma is unclear. We analyzed factors associated with overall survival in cT4b relative to cT4a oral cavity squamous cell carcinoma. Methods: We identified 6830 cT4a and 522 cT4b oral cavity squamous cell carcinoma chemoradiation or surgery + adjuvant therapy patients in the National Cancer Data Base from 2004 to 2016. The main outcome was overall survival. Statistical analysis was performed using chi-squared tests, univariable and multivariable regression analysis. Results: The cT4b group had a higher rate of positive margins (30.4% vs 21.3%, P = .009) and downstaging (41.2% vs 13.1%; P < .001) compared to cT4a, while only 1.7% were upstaged. cT4b surgery + chemoradiation patients had similar survival to cT4a surgery + radiation (HR 0.93; 95% CI, 0.70-1.25) and cT4a surgery + chemoradiation patients (HR, 0.92; 95% CI, 0.69-1.23), while cT4b surgery + radiation patients had worse OS (HR, 1.55; 95% CI, 1.05-1.47). Conclusions: Clinical T4b staging is a poor predictor of pathologic staging given a high rate of downstaging on final pathology. Surgical resection with adjuvant chemoradiation is an option in select cT4b oral cavity squamous cell carcinoma patients.

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