scholarly journals Analysis the Level of HPV16 E1 Specific Cytotoxic Lymphocyte Immune Response in Peripheral Blood of Advanced Cervical Cancer Patients with Clinical Features and Prognostic Factors

2018 ◽  
Vol 102 (3) ◽  
pp. e629
Author(s):  
M.M. Ma ◽  
R.Z. Wang
Keyword(s):  
Cervical Cancer ◽  
Immune Response ◽  
Prognostic Factors ◽  
Cancer Patients ◽  
Clinical Features ◽  
Peripheral Blood ◽  
Advanced Cervical Cancer ◽  
Cytotoxic Lymphocyte

Detection of Human Papillomavirus Types 16 and 18 mRNA in Peripheral Blood of Advanced Cervical Cancer Patients and Its Association With Prognosis

1999 ◽  
Vol 17 (5) ◽  
pp. 1391-1391 ◽  
Author(s):  
Chih-Jen Tseng ◽  
Chia C. Pao ◽  
Jen-Daw Lin ◽  
Yung-Kuei Soong ◽  
Ji-Hong Hong ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Tumor Volume ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Hpv Dna ◽  
Locally Advanced Cervical Cancer ◽  
Gene Mrna ◽  
Specific Mrna

PURPOSE: To evaluate the feasibility of detecting human papillomavirus E6 (HPVE6) gene mRNA in the peripheral blood of patients with locally advanced cervical cancer, and the relationship of the circulating HPV viral–specific mRNA with clinicopathologic factors and prognosis of locally advanced cervical cancer.PATIENTS AND METHODS: The presence of types 16 and 18 HPVE6 gene mRNA was determined by reverse transcription followed by nested polymerase chain reaction. Thirty-five patients with locally advanced cervical cancer who were positive for HPV type 16 or 18 DNA were included in the study. All patients received external-beam radiation therapy followed by intracavitary brachytherapy.RESULTS: Eighteen (51.4%) of 35 HPV DNA–positive cervical cancer patients had HPV-specific mRNA in their peripheral blood cells, compared with none of 17 HPV DNA–negative cervical cancer patients and none of 12 control volunteers. The presence of HPVE6 gene mRNA in peripheral blood was associated with bulky tumor volume (> 4 cm) and pelvic lymph node metastasis (tumor volume, P = .03; lymph node status, P = .03). After a median follow-up of 22 months, patients who were positive for peripheral-blood HPVE6 gene mRNA had a significantly higher risk of recurrence than those who were negative (10 of 18 v three of 17, P = .02; mean recurrent time, 20.7 months v 12.6 months, P = .02). There was also a statistically significant association of peripheral-blood HPVE6 gene mRNA positivity with distant metastasis (eight of 18 v one of 17; P = .01).CONCLUSION: Results of this study seem to suggest that the presence of HPVE6 gene mRNA in peripheral blood may provide an early marker that identifies patients who are at risk for metastasis.

scholarly journals Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients

2018 ◽  
Vol 08 (05) ◽  
pp. 485-496
Author(s):  
Ozlem Yetmen Dogan ◽  
Makbule Dogan Eren ◽  
Sedef Ozdemir Dag ◽  
Alparsalan Mayadağli
Keyword(s):  
Cervical Cancer ◽  
Treatment Outcome ◽  
Prognostic Factors ◽  
Cancer Patients ◽  
Locally Advanced ◽  
Advanced Cervical Cancer ◽  
Locally Advanced Cervical Cancer

scholarly journals Incidence, clinical risk and prognostic factors for liver metastasis in patients with cervical cancer: a population-based retrospective study

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hang Liu ◽  
Xiangsen Ye ◽  
Di Li ◽  
Qian Yao ◽  
Yan Li
Keyword(s):  
Cervical Cancer ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Liver Metastasis ◽  
Cancer Patients ◽  
Clinical Features ◽  
Lung Metastasis ◽  
Hepatic Metastasis ◽  
Cox Regression ◽  
Clinical Risk

Abstract Background Cervical cancer is one of the most frequent malignancies in women, particularly metastasis resulting in a poor prognosis. However, the clinical characteristics of cervical cancer patients with advanced liver metastasis have not been well investigated. We aimed to evaluate the incidence, clinical risk and prognostic factors for hepatic metastasis in cervical cancer patients. Materials and methods The clinical features of patients diagnosed with cervical cancer were collected from the Surveillance, Epidemiology and End Result (SEER) public cancer database between 2010 and 2015. Multivariate logistic and Cox regression models were performed to identify potential risk and prognostic factors for liver metastasis in patients with cervical cancer. Results A total of 431 patients (2.32%) developed liver metastasis in our analysis. The following characteristics were significantly associated with the development of liver metastasis: black ethnicity, uninsured status, higher tumor stage, poorer differentiated grade, non-squamous histology, non-surgery of primary site, patients with any additional lung, bone, and brain metastasis. Multivariate Cox regression showed that patients with additional lung metastasis, without radiotherapy, and without chemotherapy were negatively correlated with overall survival. Concurrent chemotherapy and radiotherapy was a favorable prognostic factor to improve overall survival, and chemotherapy showed to increase cause-specific survival. Additional lung metastasis was an independent characteristic for both risk and prognostic factors for hepatic metastasis in patients with cervical cancer. Conclusion Our results found several potential clinical features that may be used to assess the risk and prognosis of liver metastasis in patients with cervical cancer. These associated factors may provide clinical indications for the early identification and treatment of cervical cancer patients with hepatic metastasis.

scholarly journals Survival rate and prognostic factors in advanced cervical cancer patients accompanied by renal impairment

2005 ◽  
pp. 173
Author(s):  
Imam Rasjidi ◽  
Laila Nuranna ◽  
M. F. Aziz ◽  
Andrijono Andrijono ◽  
Sigit Purbadi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Survival Rate ◽  
Renal Impairment ◽  
Cancer Patients ◽  
Advanced Cervical Cancer

scholarly journals Elevated Expression of Programmed Death-1 and Programmed Death Ligand-1 Negatively Regulates Immune Response against Cervical Cancer Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Zhifang Chen ◽  
Nannan Pang ◽  
Rong Du ◽  
Yuejie Zhu ◽  
Lingling Fan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Immune Response ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
High Expression ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Cervical Cancer Cells ◽  
Programmed Death 1

The present study is to measure the expression of programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), as well as its clinical significance in cervical cancer patients. Our results showed that different T cell subsets in patients with cervical cancer had high expression of PD-1, and DCs had high expression of PD-L1. High expression of PD-1 on Treg cells in cervical cancer patients facilitated the production of TGF-βand IL-10 but inhibited the production of IFN-γ. Cervical cancer elevated the expression of PD-1 and PD-L1 in mRNA level. PD-1 expression in peripheral blood of cervical cancer patients was related with tumor differentiation, lymph node metastasis, and invasiveness. PD-1/PD-L1 pathway inhibited lymphocyte proliferation but enhanced the secretion of IL-10 and TGF-βin vitro. In summary, our findings demonstrate that elevated levels of PD-1/PD-L1, TGF-β, and IL-10 in peripheral blood of cervical cancer patients may negatively regulate immune response against cervical cancer cells and contribute to the progression of cervical cancer. Therefore, PD-1/PD-L1 pathway may become an immunotherapy target in the future.

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