scholarly journals Lymph Node Ratio as a Predictor of Distant Metastases in Major Salivary Gland Carcinomas

2018 ◽  
Vol 102 (3) ◽  
pp. e274
Author(s):  
N.T.A. Nguyen ◽  
S.H. Huang ◽  
W. Xu ◽  
Y. Zhang ◽  
A.J. Bayley ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Distant Metastases ◽  
Major Salivary Gland ◽  
Salivary Gland Carcinomas ◽  
Node Ratio

Lymph node ratio relationship to regional failure and distant metastases in oral cavity cancer

2017 ◽  
Vol 124 (2) ◽  
pp. 225-231 ◽  
Author(s):  
Ali Hosni ◽  
Caitlin McMullen ◽  
Shao Hui Huang ◽  
Wei Xu ◽  
Jie Su ◽  
...  
Keyword(s):  
Lymph Node ◽  
Oral Cavity ◽  
Lymph Node Ratio ◽  
Oral Cavity Cancer ◽  
Distant Metastases ◽  
Node Ratio ◽  
Regional Failure

scholarly journals Lymph node ratio (LNR) as a complementary staging system to TNM staging in salivary gland cancer

2019 ◽  
Vol 276 (12) ◽  
pp. 3425-3434 ◽  
Author(s):  
Bo-Wen Lei ◽  
Jia-Qian Hu ◽  
Peng-Cheng Yu ◽  
Yu-Long Wang ◽  
Wen-Jun Wei ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Cox Regression ◽  
Disease Free Survival ◽  
Tnm Staging ◽  
Cancer Center ◽  
Salivary Gland Cancer ◽  
Cutoff Points ◽  
Node Ratio

Abstract Purpose The role of lymph node ratio (LNR, ratio of metastatic to examined nodes) in the staging of multiple human malignancies has been reported. We aim to evaluate its value in salivary gland cancer (SGC). Methods Records of SGC patients from Surveillance, Epidemiology, and End Results database (SEER, training set, N = 4262) and Fudan University Shanghai Cancer Center (FUSCC, validating set, N = 154) were analyzed for the prognostic value of LNR. Kaplan–Meier survival estimates, the Log-rank χ2 test and Cox proportional hazards model were used for univariate and multivariate analysis. Optimal LNR cutoff points were identified by X-tile. Results Optimal LNR cutoff points classified patients into four risk groups, R0, R1 (≤ 0.17), R2 (0.17–0.56) and R3 (> 0.56), corresponding to 5-year cause-specific survival in SEER patients of 88.6%, 57.2%, 53.1% and 39.7%, disease-free survival in FUSCC patients of 69.2%, 63.3%, 34.6% and 0%, and disease-specific survival in FUSCC patients of 92.3%, 90.0%, 71.4% and 0%, respectively. Compared with TNM staging, TNM + R staging showed smaller AIC values and higher C-index values in the Cox regression model in both patient sets. Conclusions LNR classification should be considered as a complementary system to TNM staging and LNR classification based clinical trials deserve further research.

scholarly journals Clinicopathological study of salivary gland carcinomas. Cervical lymph node and distant metastases.

1993 ◽  
Vol 39 (5) ◽  
pp. 573-582 ◽  
Author(s):  
Masanori SHINOHARA ◽  
Makoto SHIMADA ◽  
Seiji NAKAMURA ◽  
Yasufumi HORINOUCHI ◽  
Takeshi HARADA ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Cervical Lymph Node ◽  
Distant Metastases ◽  
Salivary Gland Carcinomas ◽  
Clinicopathological Study

scholarly journals Lymph node ratio as a predictor for minor salivary gland cancer in head and neck

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hidenori Suzuki ◽  
Eiichi Sasaki ◽  
Gaku Takano ◽  
Seiya Goto ◽  
Daisuke Nishikawa ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Minor Salivary Gland ◽  
Salivary Gland Carcinoma ◽  
Node Ratio ◽  
Log Odds ◽  
Gland Carcinoma ◽  
Positive Lymph Nodes

Abstract Background We investigate whether pathological continuous variables of lymph nodes were related with survival results of carcinomas of minor salivary gland carcinoma in head and neck. Methods Forty-four cases with minor salivary gland carcinoma who underwent both primary resection and neck dissection were retrospectively enrolled. The pathological continuous variables were evaluated by the number of positive lymph nodes, lymph node ratio, and log odds of positive lymph nodes. Receiver operating curve analysis was used for the cut-off values of the carcinoma-specific death. Log-rank test and Cox’s proportional hazards model were used for uni−/multi-variate survival analyses adjusting for pathological stage, respectively. Results Lymph node ratio = 0.05 as well as log odds of positive lymph nodes = − 2.73 predicted the carcinoma-specific death. Both lymph node ratio and log odds of positive lymph nodes were significantly related with survival outcomes by the univariate analysis. Lymph node ratio ≥ 0.05 was associated with shorter disease-specific (hazard ratio = 7.90, 95% confidence interval = 1.54–57.1), disease-free (hazard ratio = 4.15, 95% confidence interval = 1.48–11.2) and overall (hazard ratio = 4.84, 95% confidence interval = 1.05–24.8) survival in the multivariate analysis. Conclusion A higher lymph node ratio of minor salivary gland carcinoma is a predictor of shorter survival results.

Lymph Node Ratio ist ein unabhängiger Prognoseparameter bei Patientinnen mit Vulvakarzinom

2017 ◽  
Vol 77 (04) ◽  
pp. 396-405
Author(s):  
M Kranawetter ◽  
R Schwameis ◽  
S Polterauer ◽  
I Zapardiel
Keyword(s):  
Lymph Node ◽  
Lymph Node Ratio ◽  
Node Ratio

Breast cancer preoperative 18FDG-PET, overall survival prognostic separation compared with the lymph node ratio

Breast Cancer ◽  
2021 ◽  
Author(s):  
Vincent Vinh-Hung ◽  
Hendrik Everaert ◽  
Olena Gorobets ◽  
Hilde Van Parijs ◽  
Guy Verfaillie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
18Fdg Pet ◽  
Node Ratio

scholarly journals Positive lymph node ratio is an index in predicting prognosis for remnant gastric cancer with insufficient retrieved lymph node in R0 resection

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Honghu Wang ◽  
Hao Qi ◽  
Xiaofang Liu ◽  
Ziming Gao ◽  
Iko Hidasa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Prognostic Index ◽  
Staging System ◽  
R0 Resection ◽  
Remnant Gastric Cancer ◽  
Curative Intent ◽  
Node Ratio

AbstractThe staging system of remnant gastric cancer (RGC) has not yet been established, with the current staging being based on the guidelines for primary gastric cancer. Often, surgeries for RGC fail to achieve the > 15 lymph nodes needed for TNM staging. Compared with the pN staging system, lymph node ratio (NR) may be more accurate for RGC staging and prognosis prediction. We retrospectively analyzed the data of 208 patients who underwent R0 gastrectomy with curative intent and who have ≤ 15 retrieved lymph nodes (RLNs) for RGC between 2000 and 2014. The patients were divided into four groups on the basis of the NR cutoffs: rN0: 0; rN1: > 0 and ≤ 1/6; rN2: > 1/6 and ≤ 1/2; and rN3: > 1/2. The 5-year overall survival (OS) rates for rN0, rN1, rN2, and rN3 were 84.3%, 64.7%, 31.5%, and 12.7%, respectively. Multivariable analyses revealed that tumor size (p = 0.005), lymphovascular invasion (p = 0.023), and NR (p < 0.001), but not pN stage (p = 0.682), were independent factors for OS. When the RLN count is ≤ 15, the NR is superior to pN as an important and independent prognostic index of RGC, thus predicting the prognosis of RGC patients more accurately.

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