Long-term survival with stable disease after multidisciplinary treatment for synchronous liver metastases from gastric cancer: A case report

Long-Term Survival of Two Patients with Liver Metastases from Advanced Gastric Cancer Treated with Radiofrequency Ablation and Chemotherapy

Case Reports in Oncology ◽

10.1159/000507849 ◽

2021 ◽

pp. 67-72

Author(s):

Sung Jin Oh

Keyword(s):

Gastric Cancer ◽

Radiofrequency Ablation ◽

Liver Metastases ◽

Advanced Gastric Cancer ◽

Systemic Chemotherapy ◽

Subtotal Gastrectomy ◽

Hepatic Metastases ◽

Term Survival ◽

Long Term Survival

Liver metastasis from gastric cancer has a very poor prognosis. Herein, we present two cases of liver metastases (synchronous and metachronous) from advanced gastric cancer. In the first case, the patient underwent radical subtotal gastrectomy. Liver metastases occurred 6 months after surgery while the patient was receiving adjuvant chemotherapy, but two hepatic tumors were successfully removed by radiofrequency ablation (RFA). In the second case, liver metastases occurred 15 months after surgery for gastric cancer. The patient also received RFA for one hepatic tumor, and other suspicious metastatic tumors were treated with systemic chemotherapy. Although these case presentations are limited for the efficacy of RFA treatment with systemic chemotherapy for hepatic metastases from gastric cancer, our findings showed long-term survival (overall survival for 108 and 67 months, respectively) of the affected patients, without recurrence. Therefore, we suggest that RFA treatment with systemic chemotherapy could be an effective alternative treatment modality for hepatic metastases from gastric cancer.

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Long-term survival with multiple metastasectomies for pulmonary osteosarcoma: a case report

Surgical Case Reports ◽

10.1186/s40792-020-01106-2 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Satoshi Takamori ◽

Hiroyuki Oizumi ◽

Jun Suzuki ◽

Katsuyuki Suzuki

Keyword(s):

Case Report ◽

Pulmonary Metastases ◽

Multidisciplinary Treatment ◽

Underlying Disease ◽

Pulmonary Metastasectomy ◽

Extensive Resection ◽

Term Survival ◽

Long Term Survival ◽

Primary Surgery

Abstract Background Repeat pulmonary metastasectomy (PM) considerably improves the prognosis of patients with pulmonary metastases of osteosarcoma. Reports have demonstrated a significantly improved prognosis in patients who have undergone repeat metastasectomy for osteosarcoma; however, there have been no reports with more than six metastasectomies. Herein, we describe the long-term survival of a patient following resection of multiple tumors and other treatments for metastatic osteosarcoma. Case presentation A 28-year-old woman underwent extensive resection and postoperative adjuvant chemotherapy for right tibial sarcoma. Over the years, she developed repeated pulmonary metastases. First, 116 metastases were removed from the bilateral lungs. After that, multiple PMs of approximately 250 tumors and other treatments for deep metastatic lesions were performed. The patient died of the underlying disease 24 years after the primary surgery. Conclusions This case report demonstrates the long-term survival benefit of a multidisciplinary treatment centered on multiple metastasectomies.

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Efficacy of Surgery for the Treatment of Gastric Cancer Liver Metastases: A Systematic Review of the Literature and Meta-Analysis of Prognostic Factors

Journal of Clinical Medicine ◽

10.3390/jcm10051141 ◽

2021 ◽

Vol 10 (5) ◽

pp. 1141

Author(s):

Gianpaolo Marte ◽

Andrea Tufo ◽

Francesca Steccanella ◽

Ester Marra ◽

Piera Federico ◽

...

Keyword(s):

Gastric Cancer ◽

Systematic Review ◽

Prognostic Factors ◽

Liver Metastases ◽

Meta Analysis ◽

Multidisciplinary Treatment ◽

Review Of The Literature ◽

Term Survival ◽

The Impact

Background: In the last 10 years, the management of patients with gastric cancer liver metastases (GCLM) has changed from chemotherapy alone, towards a multidisciplinary treatment with liver surgery playing a leading role. The aim of this systematic review and meta-analysis is to assess the efficacy of hepatectomy for GCLM and to analyze the impact of related prognostic factors on long-term outcomes. Methods: The databases PubMed (Medline), EMBASE, and Google Scholar were searched for relevant articles from January 2010 to September 2020. We included prospective and retrospective studies that reported the outcomes after hepatectomy for GCLM. A systematic review of the literature and meta-analysis of prognostic factors was performed. Results: We included 40 studies, including 1573 participants who underwent hepatic resection for GCLM. Post-operative morbidity and 30-day mortality rates were 24.7% and 1.6%, respectively. One-year, 3-years, and 5-years overall survival (OS) were 72%, 37%, and 26%, respectively. The 1-year, 3-years, and 5-years disease-free survival (DFS) were 44%, 24%, and 22%, respectively. Well-moderately differentiated tumors, pT1–2 and pN0–1 adenocarcinoma, R0 resection, the presence of solitary metastasis, unilobar metastases, metachronous metastasis, and chemotherapy were all strongly positively associated to better OS and DFS. Conclusion: In the present study, we demonstrated that hepatectomy for GCLM is feasible and provides benefits in terms of long-term survival. Identification of patient subgroups that could benefit from surgical treatment is mandatory in a multidisciplinary setting.

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LONG-TERM SURVIVAL OF METASTATIC CLEAR CELL ADENOCARCINOMA OF THE FEMALE URETHRA BY MULTIDISCIPLINARY TREATMENT: A CASE REPORT

The Japanese Journal of Urology ◽

10.5980/jpnjurol.104.549 ◽

2013 ◽

Vol 104 (3) ◽

pp. 549-553

Author(s):

Takahisa Suzuki ◽

Hiroshi Furuse ◽

Yutaka Kurita ◽

Takeshi Imanishi ◽

Keita Tamura ◽

...

Keyword(s):

Case Report ◽

Clear Cell ◽

Multidisciplinary Treatment ◽

Clear Cell Adenocarcinoma ◽

Female Urethra ◽

Term Survival ◽

Long Term Survival

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Long-term survival of a breast cancer patient with extensive liver metastases upon immune and virotherapy: a case report

Immunotherapy ◽

10.2217/imt.15.48 ◽

2015 ◽

Vol 7 (8) ◽

pp. 855-860 ◽

Cited By ~ 12

Author(s):

Volker Schirrmacher ◽

Wilfried Stücker ◽

Maria Lulei ◽

Akos-Sigmund Bihari ◽

Tobias Sprenger

Keyword(s):

Breast Cancer ◽

Case Report ◽

Cancer Patient ◽

Liver Metastases ◽

Breast Cancer Patient ◽

Term Survival ◽

Long Term Survival

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Long-term survival of serous cystadenocarcinoma of the pancreas with synchronous liver metastases after surgical treatment

Pancreatology ◽

10.1016/j.pan.2016.06.368 ◽

2016 ◽

Vol 16 (4) ◽

pp. S102

Author(s):

Yuichiro Maruyama ◽

Yoshiki Naito ◽

Yoshinobu Okabe ◽

Yohei Nakama ◽

Daisuke Muroya ◽

...

Keyword(s):

Surgical Treatment ◽

Liver Metastases ◽

Term Survival ◽

Long Term Survival ◽

Synchronous Liver Metastases ◽

Serous Cystadenocarcinoma

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A Case of Two Resections for Metachronous Liver Metastases of Gastric Cancer: A Case Report and Review of the Literature

Integrative Gastroenterology and Hepatology ◽

10.18314/igh.v1i1.865 ◽

2018 ◽

Vol 1 (1) ◽

pp. 01-06

Author(s):

Ishibashi Yusuke ◽

Tsujimoto Hironori ◽

Yamamoto Junji ◽

Ueno Hideki

Keyword(s):

Gastric Cancer ◽

Liver Metastases ◽

Surgical Resection ◽

Vena Cava ◽

Term Survival ◽

Case Presentation ◽

Long Term Survival ◽

Solitary Metastases ◽

Selection Of

Background: The clinical significance of surgical resection for liver metastases of gastric cancer remains controversial. Herein, we report a case of twice resections for metachronous liver metastases of gastric cancer in combination with perioperative chemotherapy, which resulted in long-term survival. Case Presentation: The patient was a 66-year-old man who underwent laparoscopic total gastrectomy for gastric cancer (Stage IB) in March 2012, and subsequently underwent right hemi-hepatectomy with partial resection of the vena cava and diaphragm for solitary metastases in segments 7-8 in April 2013. In September 2013, abdominal computed tomography detected a liver metastasis in segment 4. We administered systematic chemotherapy with S-1 plus cis-diamminedichloroplatinum (CDDP). Because the tumor decreased in size after five courses, and curative resection of the tumor was considered possible, hepatic resection of S4+1 was performed in June 2014. The patient has been followed for 26 months, and, after the last hepatectomy, had no evidence of recurrence.Conclusion: We experienced a case of long-term survival after twice resections for liver metastases from gastric cancer. Surgical resection for liver metastases of gastric cancer, even repeat hepatectomy, may be an effective treatment after careful selection of the optimal candidate.

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