An orthogonal experimental design and QuEChERS based UFLC-MS/MS for multi-pesticides and human exposure risk assessment in Honeysuckle

Beauvericin (BEA) is a cyclic hexadepsipeptide, which derives from Cordyceps cicadae. It is also produced by Fusarium species, which are parasitic to maize, wheat, rice and other important commodities. BEA increases ion permeability in biological membranes by forming a complex with essential cations, which may affect ionic homeostasis. Its ion-complexing capability allows BEA to transport alkaline earth metal and alkali metal ions across cell membranes. Importantly, increasing lines of evidence show that BEA has an anticancer effect and can be potentially used in cancer therapeutics. Normally, BEA performs the anticancer effect due to the induced cancer cell apoptosis via a reactive oxygen species-dependent pathway. Moreover, BEA increases the intracellular Ca2+ levels and subsequently regulates the activity of a series of signalling pathways including MAPK, JAK/STAT, and NF-κB, and finally causes cancer cell apoptosis. In vivo studies further show that BEA reduces tumour volumes and weights. BEA especially targets differentiated and invasive cancer types. Currently, the anticancer activity of BEA is a hot topic; however, there is no review article to discuss the anticancer activity of BEA. Therefore, in this review, we have mainly summarized the anticancer activity of BEA and thoroughly discussed its underlying mechanisms. In addition, the human exposure risk assessment of BEA is also discussed. We hope that this review will provide further information for understanding the anticancer mechanisms of BEA.

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Deoxynivalenol: signaling pathways and human exposure risk assessment—an update

Archives of Toxicology ◽

10.1007/s00204-014-1354-z ◽

2014 ◽

Vol 88 (11) ◽

pp. 1915-1928 ◽

Cited By ~ 54

Author(s):

Zhonghong Wang ◽

Qinghua Wu ◽

Kamil Kuča ◽

Vlastimil Dohnal ◽

Zhihong Tian

Keyword(s):

Risk Assessment ◽

Signaling Pathways ◽

Human Exposure ◽

Exposure Risk ◽

Exposure Risk Assessment

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Human Exposure Risk Assessment Due to Heavy Metals in Groundwater by Pollution Index and Multivariate Statistical Methods: A Case Study from South Africa

Water ◽

10.3390/w9040234 ◽

2017 ◽

Vol 9 (4) ◽

pp. 234 ◽

Cited By ~ 32

Author(s):

Vetrimurugan Elumalai ◽

K. Brindha ◽

Elango Lakshmanan

Keyword(s):

Heavy Metals ◽

South Africa ◽

Risk Assessment ◽

Human Exposure ◽

Pollution Index ◽

Exposure Risk ◽

Multivariate Statistical Methods ◽

Multivariate Statistical ◽

Exposure Risk Assessment

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Toxic metals in outdoor/indoor airborne PM2.5 in port city of Northern, China: characteristics, sources, and personal exposure risk assessment

Environmental Pollution ◽

10.1016/j.envpol.2021.116937 ◽

2021 ◽

pp. 116937

Author(s):

Bo Fang ◽

Hao Zeng ◽

Lei Zhang ◽

Hongwei Wang ◽

Jiajia Liu ◽

...

Keyword(s):

Risk Assessment ◽

Toxic Metals ◽

Northern China ◽

Personal Exposure ◽

Port City ◽

Exposure Risk ◽

Exposure Risk Assessment

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Distribution and Exposure Risk Assessment of Perfluorinated Alkyl Substances in Aquatic Products along the Coastal Region of the South China Sea

Exposure and Health ◽

10.1007/s12403-021-00399-4 ◽

2021 ◽

Author(s):

Xu-Feng Wang ◽

Meng-Song Mo ◽

Hai-Gang Chen ◽

Qiang Wang ◽

Jin-Lan Yang ◽

...

Keyword(s):

Risk Assessment ◽

South China Sea ◽

South China ◽

Coastal Region ◽

The South China Sea ◽

Exposure Risk ◽

China Sea ◽

Aquatic Products ◽

Perfluorinated Alkyl Substances ◽

Exposure Risk Assessment

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Feasibility Assessment of Wearable Respiratory Monitors for Ambulatory Inhalation Topography

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18062990 ◽

2021 ◽

Vol 18 (6) ◽

pp. 2990

Author(s):

Shehan Jayasekera ◽

Edward Hensel ◽

Risa Robinson

Keyword(s):

Risk Assessment ◽

Heart Rate ◽

Breathing Frequency ◽

Exposure Risk ◽

Analysis Software ◽

Toxicant Exposure ◽

Motion Data ◽

Feasibility Assessment ◽

Cardiopulmonary Performance ◽

Exposure Risk Assessment

Background: Natural environment inhalation topography provides useful information for toxicant exposure, risk assessment and cardiopulmonary performance. Commercially available wearable respiratory monitors (WRMs), which are currently used to measure a variety of physiological parameters such as heart rate and breathing frequency, can be leveraged to obtain inhalation topography, yet little work has been done. This paper assesses the feasibility of adapting these WRMs for measuring inhalation topography. Methods: Commercially available WRMs were compiled and assessed for the ability to report chest motion, data analysis software features, ambulatory observation capabilities, participant acceptability, purchasing constraints and affordability. Results: The following WRMs were found: LifeShirt, Equivital EQ02 LifeMonitor, Smartex WWS, Hexoskin Smart Garment, Zephyr BioHarness, Nox T3&A1, BioRadio, SleepSense Inductance Band, and ezRIP & zRIP Durabelt. None of the WRMs satisfied all six assessment criteria in a manner enabling them to be used for inhalation topography without modification and development. Conclusions: The results indicate that there are WRMs with core technologies and characteristics that can be built upon for ambulatory inhalation topography measurement in the NE.

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